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The association between cutaneous melanoma and non-Hodgkin's lymphoma (NHL) has been described. Herein we describe two cases in which lymphoma was detected in the draining lymph node basin at the time of the finding of in-transit metastasis of cutaneous melanoma. In both of these cases, sentinel lymph node biopsy at the time of the excision of the primary melanoma showed no evidence of metastatic melanoma or lymphoma. The temporal and spatial correlation of melanoma and NHL in these two cases suggests the possibility of a local failure in immune surveillance. 相似文献
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Alhassane Diallo Heike Jacobi Arron Cook Paola Giunti Michael H. Parkinson Robyn Labrum Alexandra Durr Alexis Brice Perrine Charles Cecilia Marelli Caterina Mariotti Lorenzo Nanetti Marta Panzeri Anna Castaldo Maria Rakowicz Rafal Rola Anna Sulek Tanja Schmitz‐Hübsch Ludger Schls Holger Hengel Laszlo Baliko Bela Melegh Alessandro Filla Antonella Antenora Jon Infante Jos Berciano Bart P. van de Warrenburg Dagmar Timmann Sylvia Boesch Wolfgang Nachbauer Massimo Pandolfo Jrg B. Schulz Peter Bauer Kang Jun‐Suk Thomas Klockgether Sophie Tezenas du Montcel 《Movement disorders》2019,34(8):1220-1227
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Anokhi Jambusaria‐Pahlajani Lauren D. Crow Stefan Lowenstein Giorgia L. Garrett Marc L. Melcher An‐Wen Chan John Boscardin Sarah T. Arron 《Transplant international》2019,32(12):1259-1267
Skin cancer is a common post‐transplant complication. In this study, the Skin and Ultraviolet Neoplasia Transplant Risk Assessment Calculator (SUNTRAC) was developed to stratify patients into risk groups for post‐transplant skin cancer. Data for this study were obtained from the Transplant Skin Cancer Network (TSCN), which conducted a multicenter study across 26 transplant centers in the United States. In total, 6340 patients, transplanted from 2003 and 2008, were included. Weighted point values were assigned for each risk factor based on beta coefficients from multivariable modeling: white race (9 points), pretransplant history of skin cancer (6 points), age ≥ 50 years (4 points), male sex (2 points), and thoracic transplant (1 point). Good prognostic discrimination (optimism‐corrected c statistic of 0.74) occurred with a 4‐tier system: 0–6 points indicating low risk, 7–13 points indicating medium risk, 14–17 points indicating high risk, and 18–22 points indicating very high risk. The 5‐year cumulative incidence of development of skin cancer was 1.01%, 6.15%, 15.14%, and 44.75%, for Low, Medium, High, and Very High SUNTRAC categories, respectively. Based on the skin cancer risk in different groups, the authors propose skin cancer screening guidelines based on this risk model. 相似文献
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Mario F Munoz Pinto Sandra J Campbell Christina Simoglou Karali Vanessa A Johanssen Claire Bristow Vinton W T Cheng Niloufar Zarghami James R Larkin Maria Pannell Arron Hearn Cherry Chui Barbara Brinquis Nunez Evert Bokma Robert Holgate Daniel C Anthony Nicola R Sibson 《Neuro-oncology》2022,24(1):52
BackgroundMetastasis to the brain is a major challenge with poor prognosis. The blood-brain barrier (BBB) is a significant impediment to effective treatment, being intact during the early stages of tumor development and heterogeneously permeable at later stages. Intravenous injection of tumor necrosis factor (TNF) selectively induces BBB permeabilization at sites of brain micrometastasis, in a TNF type 1 receptor (TNFR1)-dependent manner. Here, to enable clinical translation, we have developed a TNFR1-selective agonist variant of human TNF that induces BBB permeabilization, while minimizing potential toxicity.MethodsA library of human TNF muteins (mutTNF) was generated and assessed for binding specificity to mouse and human TNFR1/2, endothelial permeabilizing activity in vitro, potential immunogenicity, and circulatory half-life. The permeabilizing ability of the most promising variant was assessed in vivo in a model of brain metastasis.ResultsThe primary mutTNF variant showed similar affinity for human TNFR1 than wild-type human TNF, similar affinity for mouse TNFR1 as wild-type mouse TNF, undetectable binding to human/mouse TNFR2, low potential immunogenicity, and permeabilization of an endothelial monolayer. Circulatory half-life was similar to mouse/human TNF and BBB permeabilization was induced selectively at sites of micrometastases in vivo, with a time window of ≥24 hours and enabling delivery of agents within a therapeutically relevant range (0.5-150 kDa), including the clinically approved therapy, trastuzumab.ConclusionsWe have developed a clinically translatable mutTNF that selectively opens the BBB at micrometastatic sites, while leaving the rest of the cerebrovasculature intact. This approach will open a window for brain metastasis treatment that currently does not exist. 相似文献
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S.E. Lowenstein G. Garrett A.E. Toland A. Jambusaria‐Pahlajani M.M. Asgari A. Green E.A. Engels S.T. Arron the National Cancer Institute Keratinocyte Carcinoma Consortium 《The British journal of dermatology》2017,177(5):1202-1207
Long‐term iatrogenic immunosuppression increases the risk of cutaneous malignancies in organ transplant recipients (OTRs), particularly the keratinocyte cancers basal cell carcinoma and cutaneous squamous cell carcinoma (cSCC). cSCC is the most common malignancy in OTRs, with the risk increased to over 65‐fold in transplanted patients relative to the general population. There have been very few risk prediction tools developed for accurate determination of the risk of developing keratinocyte cancers in the OTR population. This review summarizes the prediction tools developed to date, and outlines future directions for developing more accurate prediction models that are clinically useful for the transplant physician and dermatologist. 相似文献
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