Implant Osseointegration in Circumferential Bone Defects Treated with Latex‐Derived Proteins or Autogenous Bone in Dog's Mandible

Background: In sites with diminished bone volume, the osseointegration of dental implants can be compromised. Innovative biomaterials have been developed to aid successful osseointegration outcomes. Purpose: The aim of this study was to evaluate the osteogenic potential of angiogenic latex proteins for improved bone formation and osseointegration of dental implants. Materials and Methods: Ten dogs were submitted to bilateral circumferential defects (5.0 × 6.3 mm) in the mandible. Dental implant (3.3 × 10.0 mm, TiUnite MK3?, Nobel Biocare AB, Göteborg, Sweden) was installed in the center of the defects. The gap was filled either with coagulum (Cg), autogenous bone graft (BG), or latex angiogenic proteins pool (LPP). Five animals were sacrificed after 4 weeks and 12 weeks, respectively. Implant stability was evaluated using resonance frequency analysis (Osstell Mentor?, Osstell AB, Göteborg, Sweden), and bone formation was analyzed by histological and histometric analysis. Results: LPP showed bone regeneration similar to BG and Cg at 4 weeks and 12 weeks, respectively (p ≥ .05). Bone formation, osseointegration, and implant stability improved significantly from 4 to 12 weeks (p ≤ .05). Conclusion: Based on methodological limitations of this study, Cg alone delivers higher bone formation in the defect as compared with BG at 12 weeks; compared with Cg and BG, the treatment with LPP exhibits no advantage in terms of osteogenic potential in this experimental model, although overall osseointegration was not affected by the treatments employed in this study.     

胃肠镜检查中咪唑安定联用异丙酚的价值

1 临床资料 2003-08/2004-08行胃镜检查的患者400(男218,女182)例,采用病例对照研究方法分成无痛胃镜(A)组和普通胃镜(B)组,每组各200例,两组患者在性别比例、年龄、体质量组间对比无显着性差异(P>0.05). A组iv咪唑安定和异丙酚行胃镜检查;B组在咽喉部20 g/L利多卡因表面麻醉后行胃镜检查. 另将200(男106,女94)例拟行结肠镜检查的患者分为无痛肠镜(C)组和普通肠镜(D)组,每组各100例,两组患者在性别比例、年龄、体质量组间对比无显着性差异(P>0.05).     

慢性心力衰竭238例药物的治疗

1临床资料2003-01/2004-12住院慢性心力衰竭(CHF)238(男164,女74)例,年龄32～96(平均64.9)岁;冠心病165例,高心病15例,肺心病12例,风心病41例,先心病3例,扩张型心肌病2例.合并糖尿病17例,高血压53例,肺部感染178例,其他疾病29例.     

Arterial anatomy of the lateral orbital and cheek region and arterial supply to the “peri-zygomatic perforator arteries” flap

Arterial anatomy of the lateral orbital and cheek region and subsequently of the “peri-zygomatic perforator arteries” flap is described, based upon the dissection of the 24 human cadaver head halves. Each specimen was dissected in subdermal, first fascial and deep level. The subdermal vascular network of lateral orbital and cheek region, its orientation and contributing arteries were studied. Origin, perforation sites and diameters of transverse facial, zygomaticoorbital, zygomaticofacial and zygomaticotemporal arteries were also described and measured. Our findings support the view that the cheek island flap used for lower eyelid is a reverse flow axial pattern flap. It includes arterioles of the transverse facial artery, which are part of the subdermal vascular plexus and are uniformly longitudinally oriented. The flap receives its blood supply via perforators of the zygomaticoorbital, zygomaticofacial and zygomaticotemporal arteries, which are connected via their terminal branches with transverse facial artery.     

碘化1-甲基-2,4-二氨基-6-(N-甲基-取代苄氨基)喹唑啉鎓的合成及其抗疟和抗肿瘤作用

2,4-二氨基喹唑啉类化合物具有抗肿瘤、抗菌和抗疟等多方面药理活性,已证明甲氧苄啶(甲氧苄氨嘧啶TMP)和甲氨喋呤(MTX)与受体(二氢叶酸还原酶,DHFR)结合时,杂环上N′质子化,并与DHFR的A_(sp)-27的游离羧基发生电荷转移作用。作者已报道,2,4-二氨基-6-(N-甲基-取代苄氨基)喹唑啉(Ⅰ)有强的抗疟和抗肿瘤作     

2,4-二氨基-6-(N-甲基-取代苄氨基)喹唑啉类化合物的合成和抗疟以及抗肿瘤活性

用两条不同路线合成了16个2,4-二氨基-6-(N-甲基-取代苄氨基)喹唑啉衍生物,其中13个未见报道。有4个化合物剂量5mg/kg对小鼠体内伯氏疟原虫(Plasmodium berghei)的抑制率达100%,2.5mg/kg的抑制率大于99%;有8个化合物对培养的L1210白血病细胞株的增殖抑制作用相当或优于阳性对照药物甲氨噗呤(MTX)。     

雌二醇-3,17-取代物的合成和性能

雌激素类抗辐射剂具有照前,照后给药均有效,药量小及作用时间长等特点,并能减轻放射所致造血系统的损伤。雌二醇(E_2)对某些造血组织具有一定保护作用,为提高其效果和减小毒副作用,我们以E_2为导向化合物,对其结构进行改造。     

Surgical technique to reduce scar discomfort after carpal tunnel surgery

A total of 379 patients (416 hands) with clinically diagnosed and electromyographically confirmed carpal tunnel syndrome were enrolled in a prospective study to determine the influence of a modified open decompression technique on postoperative scar discomfort. The new technique used in 184 patients (200 hands) is presented. Special attention was focused on identification and preservation of macroscopically detectable subcutaneous nerves. After using this method, which permits complete visualization of the entire transverse carpal ligament, the incidence of postoperative scar discomfort was 2.5%. This was significantly lower compared with the group of 195 patients (216 hands) treated by standard open decompression technique, without preservation of subcutaneous nerves. Primary results regarding relieving symptoms were comparable in both groups. Five anatomic variations of subcutaneous innervation, at the site of the incision in the line with the radial border of the ring finger, are described. The etiology of scar discomfort is discussed.     

Causes of febrile illnesses after a tick bite in Slovenian children

BACKGROUND: To establish the etiology in Slovenian children with febrile illnesses occurring after a tick bite. METHODS: Eighty-six febrile patients younger than 15 years referred to our institution in 2001 with a history of a tick bite within 6 weeks before onset of the illness were included in this prospective study. Acute and convalescent serum samples were tested for the presence of antibodies to tick-borne encephalitis virus, Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum, Ehrlichia chaffeensis, Rickettsia conorii, Babesia microti, Bartonella henselae, Bartonella quintana and Francisella tularensis. Cerebrospinal fluid was investigated in patients in whom meningeal involvement was clinically suspected. Blood and/or cerebrospinal fluid from the patients were cultured in modified Kelly-Pettenkofer medium. PCR was performed to detect ribosomal DNA of A. phagocytophilum and E. chaffeensis. RESULTS: Of 86 patients 33 (38%) were excluded because a well-defined febrile illness not associated with tick bite was established. Tick-borne illness was diagnosed in 28 (53%) of the 53 remaining patients. The most common diagnosis was tick-borne encephalitis (64%), followed by Lyme borreliosis (46%), human monocytic ehrlichiosis and human granulocytic ehrlichiosis (serologic evidence of infection in 9 and 4%, respectively). In 6 (21%) patients there was evidence for infection with more than 1 tick-borne agent. CONCLUSIONS: Tick-borne illness was established in 53% of the patients younger than 15 years presenting with febrile illness occurring within 6 weeks after a tick bite. The most common identified illnesses were tick-borne encephalitis and Lyme borreliosis.     

类似脑膜瘤的原始神经外胚叶肿瘤3例

1临床资料例1: 男,6岁.头痛伴癫痫1 mo,复视10 d.神志情,双侧视乳头水肿,右侧动眼神经不全麻痹,左侧巴氏征阳性.