Prevalence of serum IgE to storage mites in a southwestern Ohio population.

BACKGROUND: Storage mites of the families Chortoglyphidae, Glycyphagidae, Echimyopodidae, and Acaridae are commonly found in agricultural and nonagricultural environments. The prevalence of sensitization to these storage mites in the general population in the United States is unknown. OBJECTIVE: To determine the prevalence of serum IgE to the storage mites Lepidoglyphus destructor and Acarus siro and to evaluate the degree of co-sensitization to various other astigmatid mites in a population in southwestern Ohio. METHODS: Serum samples from 600 people randomly selected from a 1-day submission of approximately 3,000 samples to a clinical diagnostic laboratory were screened for IgE to allergens of L destructor and A siro. Proteins in the extracts of each mite were electrophoretically separated, transferred to membranes, and incubated in the serum samples, and the slot blots were probed for IgE binding using radiolabeled anti-human IgE and autoradiography. RESULTS: Thirty-two (5.3%) of the 600 serum samples screened had IgE to allergens from at least 1 of the 2 mite species; 14 (2.3%) and 20 (3.3%) had serum IgE to proteins of the mites A siro and L destructor, respectively. Additional analysis revealed that most serum samples also had IgE that bound to proteins in extracts prepared from a variety of other astigmatid mite species, but IgE binding profiles suggested little cross-reactivity. CONCLUSIONS: Sensitization to the mites L destructor and A siro is significant in this region of southwestern Ohio. Further studies are needed to determine the importance of these and other storage mites in occupationally exposed and urban populations of the United States.     

Einsichtsrecht des Patienten in die Originalbilder

Abstrakt 1. Der Patient hat gegen den ihn behandelnden Arzt einen Anspruch auf Einsichtnahme in die von diesem gefertigten Originalr?ntgenbilder. 2. Der Patient kann insoweit die überlassung der Originalr?ntgenbilder an den von ihm bevollm?chtigten Rechtsanwalt in dessen Kanzleibetrieb zum Zwecke der Einsichtnahme verlangen. Auf eine Einsichtnahme in den Praxisr?umen des Arztes muss sich der Patient nicht verweisen lassen. (Leits?tze der Bearbeiterin)     

Zur Darlegungslast und Haftung des erstbehandelnden Zahnarztes, der behauptet, M?ngel einer Prothetik seien erst durch nachbehandelnde ?rzte verursacht worden

1. §27 Abs.6 Berufsordnung der Nordrheinischen ?rztinnen und ?rzte ist eine das Marktverhalten regelnde Vorschrift i.S. des §4 Nr.11 UWG. 2. Die Eintragung in den “Gelben Seiten” ist Werbung i.S. des §27 Berufsordnung für die Nordrheinischen ?rztinnen und ?rzte. L?sst sich ein Facharzt für Mund-, Kiefer und Gesichtschirurgie in der Kategorie “plastische Chirurgie” eintragen, ohne dass sich aus diesem Eintrag ergibt, dass der Eingetragene diese Leistungen (nur) nach eigenen Angaben, also ohne objektive Best?tigung, erbringt, liegt ein Versto? gegen §27 Abs.6 Berufsordnung für die Nordrheinischen ?rztinnen und ?rzte vor. (Leits?tze des Bearbeiters)     

Correction of misaligned slices in multi-slice cardiovascular magnetic resonance using slice-to-volume registration

A popular technique to reduce respiratory motion for cardiovascular magnetic resonance is to perform a multi-slice acquisition in which a patient holds their breath multiple times during the scan. The feasibility of rigid slice-to-volume registration to correct for misalignments of slice stacks in such images due to differing breath-hold positions is explored. Experimental results indicate that slice-to-volume registration can compensate for the typical misalignments expected. Correction of slice misalignment results in anatomically more correct images, as well as improved left ventricular volume measurements. The interstudy reproducibility has also been improved reducing the number of samples needed for cardiac MR studies.     

伴或不伴有左心室收缩功能障碍的慢性心力衰竭患者中房颤与临床事件危险度的关系：来自CHARM（坎地沙坦治疗心力衰竭-降低死亡率与发病率的评估）研究的结果

房颠是慢性心衰患者中最常见的持续性心律失常。其患病率和发病率随年龄增长及心衰加重而升高，在某些研究中上升到50％。心房收缩功能的丧失导致每搏量下降，灌注压升高及心房扩大。快速心室率及不规则心律进一步降低心脏充盈和排空。房颠影响慢性心衰预后的重要性已经在临床研究、门诊病人队列研究以及流行病学研究等多种情况下得到了验证。     

Cross-antigenicity between the scabies mite, Sarcoptes scabiei, and the house dust mite, Dermatophagoides pteronyssinus.

This study demonstrated that antigens of the parasitic mite Sarcoptes scabiei (SS) cross-react with antigens of the house dust mite Dermatophagoides pteronyssinus (DP). Crossed immunoelectrophoresis (CIE) reaction of SS extract with rabbit anti-DP serum resulted in multiple immunoprecipitates. Reciprocal CIE reactions gave similar results. Immunoprecipitates from both reactions bound IgE in the sera of dust-mite-sensitive patients who had no history of scabies. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis resolved protein/peptide bands of both SS and DP also bound serum IgE from dust-mite-allergic patients following immunoblotting. Non-allergic control sera gave no IgE binding to either SS or DP antigens. These results indicate that patients with atopy to dust mites exhibit circulating antibodies built to DP but that recognize determinants on SS antigens. It is highly probable that scabietic patients build antibodies to SS antigens that also recognize DP antigens. These results raise questions concerning the reported isotypic antibody responses to SS because the sensitivity of scabietic patients to house dust mites has not been previously evaluated. This cross-reactivity may play an important role in the susceptibility to scabies and its clinical manifestations.     

Zum Umfang des Schadensersatzes für die Geburt eines behinderten Kindes nach fehlerhafter Beratung

Ohne Zusammenfassung     

“Arzt-Such-Service”

Ohne Zusammenfassung     

Control of an outbreak of a highly beta-lactam-resistant Enterobacter cloacae strain in a neonatal special care unit

Two successive outbreaks of colonization and infection with Enterobacter cloacae resistant to third generation cephalosporins (cephalosporin-resistant E. cloacae, CREC) and involving 15 infants occurred within 12 months in a neonatal special care unit. Isolates of clinical significance were obtained from four infants (urine 2 cases, blood, pleural drainage). According to epidemiological typing using computerized biochemical fingerprinting and pulsed-field gel electrophoresis (PFGE) the same CREC strain was found in both outbreaks. The origin of the strain and its reservoir between the two outbreaks remained unknown. Emphasizing strict barrier nursing of the infants had little or no impact on the presence and transmission of the strain in the unit. In contrast, replacing ampicillin plus cefotaxime as standard empiric therapy with penicillin G plus netilmicin plus consequent cohorting of newborns and staff promptly halted both the outbreaks. During a 5-y follow-up after the last episode, the choice of antibiotics for empirical treatment has varied, and no further outbreaks of CREC have been seen, with the exception of two sporadic cases.