全文获取类型
收费全文 | 222篇 |
免费 | 20篇 |
国内免费 | 2篇 |
专业分类
儿科学 | 4篇 |
妇产科学 | 9篇 |
基础医学 | 58篇 |
口腔科学 | 1篇 |
临床医学 | 17篇 |
内科学 | 83篇 |
神经病学 | 11篇 |
外科学 | 24篇 |
综合类 | 2篇 |
一般理论 | 1篇 |
预防医学 | 21篇 |
眼科学 | 1篇 |
药学 | 6篇 |
肿瘤学 | 6篇 |
出版年
2022年 | 4篇 |
2021年 | 8篇 |
2020年 | 2篇 |
2019年 | 9篇 |
2018年 | 6篇 |
2017年 | 1篇 |
2016年 | 4篇 |
2015年 | 4篇 |
2014年 | 11篇 |
2013年 | 4篇 |
2012年 | 16篇 |
2011年 | 27篇 |
2010年 | 7篇 |
2009年 | 21篇 |
2008年 | 13篇 |
2007年 | 21篇 |
2006年 | 10篇 |
2005年 | 14篇 |
2004年 | 10篇 |
2003年 | 16篇 |
2002年 | 14篇 |
2001年 | 1篇 |
1999年 | 2篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1981年 | 3篇 |
1980年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有244条查询结果,搜索用时 31 毫秒
71.
Tirza Cohen Moshe Zeitune Barbara C. McGillivray Judith G. Hall Audrey H. Lynn Christopher E. Aston Aravinda Chakravarti 《American journal of medical genetics. Part A》1996,65(3):226-234
Microcephaly is a heterogeneous disorder with genetic and environmental causes. However, there is little information on what proportion of cases are caused by inherited susceptibility, or the mode of inheritance in familial cases. To address these questions, we have performed classical and complex segregation analyses for microcephaly on 2 sets of family data collected from genetic counseling clinics in Vancouver and Jerusalem. These samples consisted of 143 affected individuals in 127 families ascertained from Vancouver, and 101 affected individuals in 59 families ascertained from Jerusalem. The results of the segregation analyses for the Vancouver sample indicated that approximately half of all microcephaly cases were due to highly penetrant recessive mutant alleles, with the remainder being sporadic. Although a recessive model allowing for the occurrence of sporadic cases fit the data from Vancouver best, a dominant model could not be statistically rejected. The classical segregation analysis on the Jerusalem sample suggested that both a dominant model with 29% of the cases being sporadic and a purely recessive model provided adequate fit to the data. Although the complex segregation analysis of this sample indicated that a dominant model provided a more parsimonious explanation for the observed familial variation, a recessive model was only marginally rejected. It should be noted that in the Jerusalem sample, families tended to be ascertained in the genetic counseling clinic only after the birth of a second affected child. This could be a potential bias which could inflate the segregation ratio, thus giving the impression of dominant inheritance. Our analyses, while confirming the complex nature of the cause of microcephaly, indicate that it may be necessary to await the results of genetic linkage analysis before a definitive mode of inheritance can be determined. © 1996 Wiley-Liss, Inc. 相似文献
72.
Broadwater AH Sonenshine DE Hynes WL Ceraul S De SA 《Journal of medical entomology》2002,39(2):285-292
We evaluated an artificial capillary feeding method to infect nymphal Ixodes scapularis (Say) ticks with Borrelia burgdoeferi, the causative agent of Lyme disease. Thirty to 70% of the nymphs were infected after feeding for 2.5 h from glass capillary tubes filled with a solution of spirochetes. Capillary infection was stable and persisted in the nymphs for at least 10 d after feeding. Capillary feeding also maintained natural vector competence patterns because I. scapularis ticks acquired infection unlike Dermacentor variablis (Say), which did not become infected. Capillary infected I. scapularis nymphs were capable of transmitting the infection to naive mice although not as efficiently as naturally infected nymphs. The capillary infection method is convenient and is a better alternative to syringe inoculation as a means of infecting animals with B. burgdorferi. 相似文献
73.
High-Throughput Variation Detection and Genotyping Using Microarrays 总被引:20,自引:2,他引:18
David J. Cutler Michael E. Zwick Minerva M. Carrasquillo Christopher T. Yohn Katherine P. Tobin Carl Kashuk Debra J. Mathews Nila A. Shah Evan E. Eichler Janet A. Warrington Aravinda Chakravarti 《Genome research》2001,11(11):1913-1925
The genetic dissection of complex traits may ultimately require a large number of SNPs to be genotyped in multiple individuals who exhibit phenotypic variation in a trait of interest. Microarray technology can enable rapid genotyping of variation specific to study samples. To facilitate their use, we have developed an automated statistical method (ABACUS) to analyze microarray hybridization data and applied this method to Affymetrix Variation Detection Arrays (VDAs). ABACUS provides a quality score to individual genotypes, allowing investigators to focus their attention on sites that give accurate information. We have applied ABACUS to an experiment encompassing 32 autosomal and eight X-linked genomic regions, each consisting of approximately 50 kb of unique sequence spanning a 100-kb region, in 40 humans. At sufficiently high-quality scores, we are able to read approximately 80% of all sites. To assess the accuracy of SNP detection, 108 of 108 SNPs have been experimentally confirmed; an additional 371 SNPs have been confirmed electronically. To access the accuracy of diploid genotypes at segregating autosomal sites, we confirmed 1515 of 1515 homozygous calls, and 420 of 423 (99.29%) heterozygotes. In replicate experiments, consisting of independent amplification of identical samples followed by hybridization to distinct microarrays of the same design, genotyping is highly repeatable. In an autosomal replicate experiment, 813,295 of 813,295 genotypes are called identically (including 351 heterozygotes); at an X-linked locus in males (haploid), 841,236 of 841,236 sites are called identically. 相似文献
74.
Fahim Mohamed Aravinda Perera Kusal Wijayaweera Keerthi Kularatne Shaluka Jayamanne Michael Eddleston Andrew Dawson Flemming Konradsen David Gunnell 《Social psychiatry and psychiatric epidemiology》2011,46(6):517-520
Background
One of the most important components of suicide prevention strategies is to target people who repeat self-harm as they are a high risk group. However, there is some evidence that the incidence of repeat self-harm is lower in Asia than in the West. The objective of this study was to investigate the prevalence of previous self-harm among a consecutive series of self-harm patients presenting to hospitals in rural Sri Lanka. 相似文献75.
Sarah H. Kehoe Ghattu V. Krishnaveni Sargoor R. Veena Aravinda M. Guntupalli Barrie M. Margetts Caroline H.D. Fall Sian M. Robinson 《Maternal & child nutrition》2014,10(1):145-158
The burden of non‐communicable chronic disease (NCD) in India is increasing. Diet and body composition ‘track’ from childhood into adult life and contribute to the development of risk factors for NCD. Little is known about the diet patterns of Indian children. We aimed to identify diet patterns and study associations with body composition and socio‐demographic factors in the Mysore Parthenon Study cohort. We collected anthropometric and demographic data from children aged 9.5 years (n = 538). We also administered a food frequency questionnaire and measured fasting blood concentrations of folate and vitamin B12. Using principal component analysis, we identified two diet patterns. The ‘snack and fruit’ pattern was characterised by frequent intakes of snacks, fruit, sweetened drinks, rice and meat dishes and leavened breads. The ‘lacto‐vegetarian’ pattern was characterised by frequent intakes of finger millet, vegetarian rice dishes, yoghurt, vegetable dishes and infrequent meat consumption. Adherence to the ‘snack and fruit’ pattern was associated with season, being Muslim and urban dwelling. Adherence to the lacto‐vegetarian pattern was associated with being Hindu, rural dwelling and a lower maternal body mass index. The ‘snack and fruit’ pattern was negatively associated with the child's adiposity. The lacto‐vegetarian pattern was positively associated with blood folate concentration and negatively with vitamin B12 concentration. This study provides new information on correlates of diet patterns in Indian children and how diet relates to nutritional status. Follow‐up of these children will be important to determine the role of these differences in diet in the development of risk factors for NCD including body composition. 相似文献
76.
Mehul Patel Parthasarathy Satishchandra Hanumanthapura Aravinda Rose D. Bharath Sanjib Sinha 《Annals of Indian Academy of Neurology》2014,17(4):470-472
We studied the anatomical correlates of reflex hot water epilepsy (HWE) using multimodality investigations viz. magnetic resonance imaging (MRI), electroencephalography (EEG), and single photon emission computed tomography (SPECT). Five men (mean age: 27.0 5.8 years) with HWE were subjected to MRI of brain, video-EEG studies, and SPECT scan. These were correlated with phenotypic presentations. Seizures could be precipitated in three patients with pouring of hot water over the head and semiology of seizures was suggestive of temporal lobe epilepsy. Ictal SPECT showed hyperperfusion in: left medial temporal — one, left lateral temporal — one, and right parietal — one. Interictal SPECT was normal in all five patients and did not help in localization. MRI and interictal EEG was normal in all the patients. The clinical and SPECT studies suggested temporal lobe as the seizure onset zone in some of the patients with HWE. 相似文献
77.
Al Zenki S Al Omirah H Al Hooti S Al Hamad N Jackson RT Rao A Al Jahmah N Al Obaid I Al Ghanim J Al Somaie M Zaghloul S Al Othman A 《International journal of environmental research and public health》2012,9(5):1984-1996
The socio-economic development which followed the discovery of oil resources brought about considerable changes in the food habits and lifestyle of the Kuwaiti population. Excessive caloric intake and decreased energy expenditure due to a sedentary lifestyle have led to a rapid increase in obesity, diabetes and other non-communicable chronic diseases in the population. In this paper, we examine the prevalence of the Metabolic Syndrome (MetS) among Kuwaiti adults (≥20 years) using data from the first national nutrition survey conducted between July 2008 and November 2009. The prevalence of MetS was 37.7% in females and 34.2% in males by NCEP criteria, whereas the values were 40.1% in females and 41.7% in males according to IDF criteria. Prevalence of MetS increased with age and was higher in females than males. The high prevalence of the MetS in Kuwaiti adults warrants urgent public health measures to prevent morbidity and mortality due to cardiovascular complications in the future. 相似文献
78.
Jeannette Simino Rezart Kume Aldi T. Kraja Stephen T. Turner Craig L. Hanis Wayne H.-H. Sheu Yii-Der Ida Chen Cashell E. Jaquish Richard S. Cooper Aravinda Chakravarti Thomas Quertermous Eric Boerwinkle Steven C. Hunt D.C. Rao 《Atherosclerosis》2014
Objective
To detect novel loci with age-dependent effects on fasting (≥8 h) levels of total cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides using 3600 African Americans, 1283 Asians, 3218 European Americans, and 2026 Mexican Americans from the Family Blood Pressure Program (FBPP).Methods
Within each subgroup (defined by network, race, and sex), we employed stepwise linear regression (retention p ≤ 0.05) to adjust lipid levels for age, age-squared, age-cubed, body-mass-index, current smoking status, current drinking status, field center, estrogen therapy (females only), as well as antidiabetic, antihypertensive, and antilipidemic medication use. For each trait, we pooled the standardized male and female residuals within each network and race and fit a generalized variance components model that incorporated gene–age interactions. We conducted FBPP-wide and race-specific meta-analyses by combining the p-values of each linkage marker across subgroups using a modified Fisher's method.Results
We identified seven novel loci with age-dependent effects; four total cholesterol loci from the meta-analysis of Mexican Americans (on chromosomes 2q24.1, 4q21.21, 8q22.2, and 12p11.23) and three high-density lipoprotein loci from the meta-analysis of all FBPP subgroups (on chromosomes 1p12, 14q11.2, and 21q21.1). These loci lacked significant genome-wide linkage or association evidence in the literature and had logarithm of odds (LOD) score ≥ 3 in the meta-analysis with LOD ≥ 1 in at least two network and race subgroups (exclusively of non-European descent).Conclusion
Incorporating gene–age interactions into the analysis of lipids using multi-ethnic cohorts can enhance gene discovery. These interaction loci can guide the selection of families for sequencing studies of lipid-associated variants. 相似文献79.
Sandra Henein Cameron Adams Matthew Bonaparte Janice M. Moser Alina Munteanu Ralph Baric Aravinda M. de Silva 《The Journal of clinical investigation》2021,131(13)
The 4 serotypes of dengue virus (DENV1–4) are mosquito-borne flaviviruses that infect humans. Live attenuated tetravalent DENV vaccines are at different phases of clinical testing. DENV vaccine developers have relied on neutralizing antibodies (NAbs) as a correlate of protection. A leading tetravalent vaccine (Dengvaxia) stimulated NAbs to the 4 DENV serotypes, yet overall vaccine efficacy was low in children who were DENV seronegative at baseline before vaccination. We compared the properties of (a) NAbs induced by WT DENV1 or DENV3 infections, which are strongly correlated with protection from repeat infections, and (b) NAbs induced by Dengvaxia in individuals who subsequently experienced DENV1 or DENV3 breakthrough infections. WT infections induced NAbs that recognized epitopes unique (type specific) to each serotype, whereas the vaccine stimulated qualitatively different NAbs that recognized epitopes conserved (crossreactive) between serotypes. Our results indicate that, among children who were DENV-seronegative at baseline, unbalanced replication of the DENV type 4 vaccine component in the tetravalent vaccine stimulates Abs capable of crossneutralizing DENV1 and DENV3 in vitro, but not protecting in vivo. In DENV-seronegative individuals who are vaccinated, we propose that type-specific NAbs are a better correlate of protection than total levels of NAbs. 相似文献
80.
Ramesh Daggubati Gianluca Rigatelli Thach Nguyen Aravinda Nanjundapp Charles Chambers 《中华医学杂志(英文版)》2014,127(6):1194-1195
Dreat changes have been made in the field ofinterventional cardiology from the time AndreasGruentzig performed the first coronary angioplasty in1977. For cardiac catheterization laboratory (CCL)directors, one of the challenges is management skill. This issomething that is not taught in medical schools, residencyor fellowship programs. There is more to being a CCLdirector than just being the best interventional cardiologistin a hospital. A CCL director is more of a manager in aninformation technology (IT) firm or a teacher in a technicalschool. At times, there is a need to lead by example andat times to lead by making changes in a protocol forphysicians to follow. 相似文献