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排序方式: 共有5121条查询结果,搜索用时 15 毫秒
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José Alexandre da Rocha Curvelo Anna Lea Silva Barreto Camila A. dos Anjos Rafaela S. Santana Ariadne Nunes Alonso Maria Teresa Vilela Romanos Kelly C. G. de Moura Paula Fernandes Carneiro Maristela Barbosa Portela Maria do Carmo F. R. Pinto Rosangela Maria de Araújo Soares 《Medicinal chemistry research》2015,24(3):1155-1161
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Freitas Raquel Martins Patrícia Dourado Eduardo Santiago Tânia Guimarães Francisca Fernandes Bruno Miguel Garcia Salomé Samões Beatriz Pinto Ana Sofia Gonçalves Nuno Lourenco Maria Helena Costa Emanuel Rocha Margarida Couto Maura Duarte Ana Catarina Araújo Filipe Cordeiro Inês Godinho Fátima Resende Catarina Salvador Maria João Cordeiro Ana Santos Maria José 《Clinical rheumatology》2022,41(4):1139-1144
Clinical Rheumatology - Evidence for the role of sex in the clinical manifestations of systemic sclerosis (SSc) patients is emerging. Some multicenter cohorts have shown that male SSc patients have... 相似文献
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Emy Hiura Aline del Carmen Garcia Lopes Jeanne Saraiva da Paz Maylla Garschagen Gava Mayra Cunha Flecher Manuela Colares Filippe Elias de Freitas Soares Leandro Abreu da Fonseca Tracy Lacerda Jackson Victor de Araújo Fabio Ribeiro Braga 《Parasitology research》2015,114(9):3301-3308
The objective of this study was to evaluate the infectivity of Toxocara canis eggs after interacting with isolated nematophagous fungi of the species Duddingtonia flagrans (AC001) and Pochonia chlamydosporia (VC4), and test the predatory activity of the isolated AC001 on T. canis second stage larvae after 7 days of interaction. In assay A, 5000 embryonated T. canis eggs previously in contact with the AC001 and VC4 isolated for 10 days were inoculated into domestic chickens (Gallus gallus domesticus), and then these animals were necropsied to collect material (digested liver, intestine, muscles and lungs) at 3-, 7-, 14-, and 21-day intervals after inoculation. In assay A, the results demonstrated that the prior interaction of the eggs with isolated AC001 and VC4 decreases the amount of larvae found in the collected organs. Difference (p?<?0.01) was observed in the medium larvae counts recovered from liver, lung, intestine, and muscle of animals in the treated groups when compared to the animals in the control group. At the end of assay A, a percentage reduction of 87.1 % (AC001) and 84.5 % (VC4) respectively was recorded. In the result of assay B, the isolated AC001 showed differences (p?<?0.01) compared to the control group, with a reduction of 53.4 % in the recovery of L2. Through these results, it is justified to mention that prior interaction of embryonated T. canis eggs with the tested fungal isolates were efficient in reducing the development and migration of this parasite, in addition to the first report of proven predatory activity on L2. 相似文献
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Martínez Ara J Picazo ML Torre A Pascual D Díaz Rodríguez C Riñón C 《Nefrología : publicación oficial de la Sociedad Espa?ola Nefrologia》2000,20(4):383-386
Sclerodema renal crisis is the usual form of presentation of renal disease in systemic sclerosis. We report a woman who at age 63 was given a diagnosis of scleroderma with Raynaud's phenomenon and cutaneous, oesophageal and lung involvement but no evidence of renal disease and no treatment with D-penicillamine. Two years later she developed progressive renal failure, nephrotic range proteinuria, haematuria and the presence of serum MPO-ANCA; she was normotensive. Renal biopsy revealed extracapillary and necrotizing glomerulonephritis and skin biopsy showed leucocytoclastic vasculitis. This clinical picture was compatible with necrotizing vasculitis of the microscopic polyarterits type. After treatment with pulse steroids followed by oral steroids and monthly intravenous cyclophosphamide her renal function stabilised and the serum MPO-ANCA disappeared. 相似文献