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Heinzerling Keith G. Briones Marisa Thames April D. Hinkin Charles H. Zhu Tianle Wu Ying Nian Shoptaw Steven J. 《Journal of neuroimmune pharmacology》2020,15(2):238-248
Journal of Neuroimmune Pharmacology - Methamphetamine (MA) triggers neuroinflammation and medications that counteract MA-induced neuroinflammation may reduce MA-induced neurodegeneration and... 相似文献
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Dawn Peck Amy White Gisele Pino April Studinski Meghan Strenk Randi Gadea Jennifer Gannon Bryce Heese Esperanza Font-Montgomery Tracy Klug Jennifer Burton George Hoganson Devin Oglesbee Dimitar Gavrilov Dietrich Matern Kimiyo Raymond Piero Rinaldo Silvia Tortorelli 《Molecular genetics and metabolism》2021
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Araño Keith April Gloor Peter Orsenigo Carlotta Vercellis Carlo 《Cognitive computation》2021,13(3):771-783
Cognitive Computation - Speech is one of the most natural communication channels for expressing human emotions. Therefore, speech emotion recognition (SER) has been an active area of research with... 相似文献
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Adrienne A. Taren Peter J. Gianaros Carol M. Greco Emily K. Lindsay April Fairgrieve Kirk Warren Brown Rhonda K. Rosen Jennifer L. Ferris Erica Julson Anna L. Marsland James K. Bursley Jared Ramsburg J. David Creswell 《Social cognitive and affective neuroscience》2015,10(12):1758-1768
Recent studies indicate that mindfulness meditation training interventions reduce stress and improve stress-related health outcomes, but the neural pathways for these effects are unknown. The present research evaluates whether mindfulness meditation training alters resting state functional connectivity (rsFC) of the amygdala, a region known to coordinate stress processing and physiological stress responses. We show in an initial discovery study that higher perceived stress over the past month is associated with greater bilateral amygdala-subgenual anterior cingulate cortex (sgACC) rsFC in a sample of community adults (n = 130). A follow-up, single-blind randomized controlled trial shows that a 3-day intensive mindfulness meditation training intervention (relative to a well-matched 3-day relaxation training intervention without a mindfulness component) reduced right amygdala-sgACC rsFC in a sample of stressed unemployed community adults (n = 35). Although stress may increase amygdala-sgACC rsFC, brief training in mindfulness meditation could reverse these effects. This work provides an initial indication that mindfulness meditation training promotes functional neuroplastic changes, suggesting an amygdala-sgACC pathway for stress reduction effects. 相似文献
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Aryun Kim Amy Kutschke David E. Ehmann Sara A. Patey Jared L. Crandon Elise Gorseth Alita A. Miller Robert E. McLaughlin Christina M. Blinn April Chen Asha S. Nayar Brian Dangel Andy S. Tsai Michael T. Rooney Kerry E. Murphy-Benenato Ann E. Eakin David P. Nicolau 《Antimicrobial agents and chemotherapy》2015,59(12):7743-7752
The objective of this study was to investigate the risk of attenuated efficacy due to adaptive resistance for the siderophore-conjugated monocarbam SMC-3176 in Pseudomonas aeruginosa by using a pharmacokinetic/pharmacodynamic (PK/PD) approach. MICs were determined in cation-adjusted Mueller-Hinton broth (MHB) and in Chelex-treated, dialyzed MHB (CDMHB). Spontaneous resistance was assessed at 2× to 16× the MIC and the resulting mutants sequenced. Efficacy was evaluated in a neutropenic mouse thigh model at 3.13 to 400 mg/kg of body weight every 3 h for 24 h and analyzed for association with free time above the MIC (fT>MIC). To closer emulate the conditions of the in vivo model, we developed a novel assay testing activity mouse whole blood (WB). All mutations were found in genes related to iron uptake: piuA, piuC, pirR, fecI, and pvdS. Against four P. aeruginosa isolates, SMC-3176 displayed predictable efficacy corresponding to the fT>MIC using the MIC in CDMHB (R2 = 0.968 to 0.985), with stasis to 2-log kill achieved at 59.4 to 81.1%. Efficacy did not translate for P. aeruginosa isolate JJ 4-36, as the in vivo responses were inconsistent with fT>MIC exposures and implied a threshold concentration that was greater than the MIC. The results of the mouse WB assay indicated that efficacy was not predictable using the MIC for JJ 4-36 and four additional isolates, against which in vivo failures of another siderophore-conjugated β-lactam were previously reported. SMC-3176 carries a risk of attenuated efficacy in P. aeruginosa due to rapid adaptive resistance preventing entry via the siderophore-mediated iron uptake systems. Substantial in vivo testing is warranted for compounds using the siderophore approach to thoroughly screen for this in vitro-in vivo disconnect in P. aeruginosa. 相似文献
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Morquio A Syndrome‐Associated Mutations: A Review of Alterations in the GALNS Gene and a New Locus‐Specific Database 下载免费PDF全文
Amelia Morrone Anna Caciotti Robert Atwood Kathryn Davidson Chaoyi Du Patricia Francis‐Lyon Paul Harmatz Matthew Mealiffe Sean Mooney Tal Ronnen Oron April Ryles Karl A. Zawadzki Nicole Miller 《Human mutation》2014,35(11):1271-1279
Morquio A syndrome (mucopolysaccharidosis IVA) is an autosomal recessive disorder that results from deficient activity of the enzyme N‐acetylgalactosamine‐6‐sulfatase (GALNS) due to alterations in the GALNS gene, which causes major skeletal and connective tissue abnormalities and effects on multiple organ systems. The GALNS alterations associated with Morquio A are numerous and heterogeneous, and new alterations are continuously identified. To aid detection and interpretation of GALNS alterations, from previously published research, we provide a comprehensive and up‐to‐date listing of 277 unique GALNS alterations associated with Morquio A identified from 1,091 published GALNS alleles. In agreement with previous findings, most reported GALNS alterations are missense changes and even the most frequent alterations are relatively uncommon. We found that 48% of patients are assessed as homozygous for a GALNS alteration, 39% are assessed as heterozygous for two identified GALNS alterations, and in 13% of patients only one GALNS alteration is detected. We report here the creation of a locus‐specific database for the GALNS gene ( http://galns.mutdb.org/ ) that catalogs all reported alterations in GALNS to date. We highlight the challenges both in alteration detection and genotype–phenotype interpretation caused in part by the heterogeneity of GALNS alterations and provide recommendations for molecular testing of GALNS. 相似文献