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31.
Changes in the cause of death among HIV positive subjects across Europe: results from the EuroSIDA study 总被引:12,自引:0,他引:12
Mocroft A Brettle R Kirk O Blaxhult A Parkin JM Antunes F Francioli P D'Arminio Monforte A Fox Z Lundgren JD;EuroSIDA study group 《AIDS (London, England)》2002,16(12):1663-1671
OBJECTIVES: The causes of death among HIV-positive patients may have changed since the introduction of highly active antiretroviral therapy (HAART). We investigated these changes, patients who died without an AIDS diagnosis and factors relating to pre-AIDS deaths. METHODS: Analyses of 1826 deaths among EuroSIDA patients, an observational study of 8556 patients. Incidence rates of pre-AIDS deaths were compared to overall rates. Factors relating to pre-AIDS deaths were identified using Cox regression. RESULTS: Death rates declined from 15.6 to 2.7 per 100 person-years of follow-up (PYFU) between 1994 and 2001. Pre-AIDS incidence declined from 2.4 to 1.1 per 100 PYFU. The ratio of overall to pre-AIDS deaths peaked in 1996 at 8.4 and dropped to < 3 after 1998. The adjusted odds of dying following one AIDS defining event (ADE) increased yearly (odds ratio, 1.53; P < 0.001), conversely the odds of dying following three or more ADE decreased yearly (odds ratio, 0.79; P < 0.001). The proportion of deaths that followed an HIV-related disease decreased by 23% annually; in contrast there was a 32% yearly increase in the proportion of deaths due to known causes other than HIV-related or suicides. Injecting drug users (IDU) were significantly more likely to die before an ADE than homosexuals (relative hazard, 2.97; P < 0.0001) and patients from northern/eastern Europe (relative hazard, 2.01; P < 0.0001) were more likely to die pre-AIDS than southern patients. CONCLUSIONS: The proportion of pre-AIDS deaths increased from 1994 to 2001; however, the incidence of pre-AIDS deaths and deaths overall declined. IDU and subjects from northern/eastern Europe had an increased risk of pre-AIDS death. HIV-positive patients live longer therefore it is essential to continue to monitor all causes of mortality to identify changes. 相似文献
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Dimicoli S Bensoussan D Latger-Cannard V Straczek J Antunes L Mainard L Dao A Barbe F Araujo C Clément L Feugier P Lecompte T Stoltz JF Bordigoni P 《Bone marrow transplantation》2003,32(7):733-737
We describe two brothers who suffered from hyper-IgM syndrome (HIGM1) with similar clinical features: recurrent infections, especially cryptosporidium gastroenteritis with cholangitis. Their activated T cells did not express CD40L. Nucleotide sequencing revealed a mutation in both boys with respect to intron 4 and exon 5 boundaries of the CD40L gene in Xq26. They underwent successful bone marrow transplantation (BMT) from HLA-geno-identical siblings. The Cryptosporidium infection and cholangitis resolved thereafter. At 6 months after BMT, expression of CD40L on activated T lymphocytes was normal. After 1 year, both boys are well, and immune reconstitution has improved. Based on these two successful experiences, BMT with a genoidentical sibling seems a reasonable therapeutic approach for HIGM1, if Cryptosporidium infection occurs. 相似文献
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de Alvarenga Antunes Carla Valéria de Alvarenga Nascimento Cristiano Rodrigo Campanha da Rocha Ribeiro Tarsila de Alvarenga Antunes Priscila de Andrade Chebli Liliana Martins Gonçalves Fava Lidiane Malaguti Carla Maria Fonseca Chebli Julio 《International journal of clinical pharmacy》2020,42(3):895-902
International Journal of Clinical Pharmacy - Background Anemia is a clinical condition frequently seen in patients with inflammatory bowel disease, which is responsible for a significant loss of... 相似文献
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Pinheiro Liz Helena Moraes Guimarães Ludmila Silva Antunes Leonardo Santos Küchler Erika Calvano Kirschneck Christian Antunes Lívia Azeredo Alves 《Clinical oral investigations》2021,25(10):5613-5627
Clinical Oral Investigations - To perform a systematic review/meta-analysis to elucidate the scientific basis for the association between genetic variations and risk of external apical root... 相似文献
37.
Pedro Luiz Toledo de Arruda Lourenção Bonifácio Katsunori Takegawa Erika Veruska Paiva Ortolan Simone Antunes Terra Maria Aparecida Marchesan Rodrigues 《Annals of diagnostic pathology》2013,17(4):352-356
The pathological evaluation of rectal biopsies for the diagnosis of Hirschsprung disease has been a challenging issue. We analyzed prospectively the usefulness of calretinin immunostaining and acetylcholinesterase (AChE) histochesmistry in rectal biopsies for the diagnosis of Hirschsprung disease. Frozen tissue samples from 43 patients were used for AChE histochemistry and paraffin-embedded sections for calretinin immunohistochemistry and conventional histology (hematoxylin and eosin [H&E]). Activity for AChE, was demonstrated in 13 of 43 cases, and the absence of immunoreactivity for calretinin was observed in 14 of 43 cases. Conventional histology (H&E) did not reveal ganglion cells in 24 of 43 cases. The results on calretinin were in good agreement with AChE according to the κ index (0.946; P < .001) and presented significantly higher specificity (96.7 × 63.3; P < .002) and accuracy (97.6 × 74.4; P < .003) when compared with conventional histology (H&E). The final diagnosis of Hirschsprung disease was confirmed in 13 of 43 patients who were submitted to surgical treatment. The results of the present study indicate that calretinin can be a good tool in ruling out the diagnosis of Hirschsprung disease, by showing positive staining in ganglion cells and intrinsic nerve fibers, whereas AChE is useful in confirming the diagnosis of Hirschsprung disease, by revealing activity of this enzyme in hypertrophied nerve fibers. The association between calretinin and AChE can be a useful panel for the histopathologic evaluation of rectal biopsies for the diagnosis of Hirschsprung disease. 相似文献
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Joycellane Alline do Nascimento Campos Ribeiro Alexandre Coellho Serquiz Priscila Fabíola dos Santos Silva Patrícia Batista Barra Medeiros Barbosa Tarcísio Bruno Montenegro Sampaio Raimundo Fernandes de Araújo Junior Adeliana Silva de Oliveira Richele Janaina Araújo Machado Bruna Leal Lima Maciel Adriana Ferreira Uch?a Elizeu Antunes dos Santos Ana Heloneida de Araújo Morais 《Clinics (S?o Paulo, Brazil)》2015,70(2):136-143