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991.
Carmen Andrade Ana Martínez-Serrano Miguel ngel Sanjun Jos Antonio Tenorio Ríos 《Materials》2021,14(5)
The Portland cement industry is presently deemed to account for around 7.4% of the carbon dioxide emitted annually worldwide. Clinker production is being reduced worldwide in response to the need to drastically lower greenhouse gas emissions. The trend began in the nineteen seventies with the advent of mineral additions to replace clinker. Blast furnace slag and fly ash, industrial by-products that were being stockpiled in waste heaps at the time, have not commonly been included in cements. Supply of these additions is no longer guaranteed, however, due to restrained activity in the source industries for the same reasons as in clinker production. The search is consequently on for other additions that may lower pollutant gas emissions without altering cement performance. In this study, bentonite, a very common clay, was used as such an addition directly, with no need for precalcination, a still novel approach that has been scantly explored to date for reinforced structural concrete with structural applications. The results of the mechanical strength and chemical resistance (to sulfates, carbonation and chlorides) tests conducted are promising. The carbonation findings proved to be of particular interest, for that is the area where cement with mineral additions tends to be least effective. In the bentonite-bearing material analysed here, however, carbonation resistance was found to be as low as or lower than that observed in plain Portland cement. 相似文献
992.
Laguna Benjamin Westphalen Antonio C. Guimarães C. T. Whang Zhen Simko Jeff Zagoria Ronald 《Abdominal imaging》2019,44(4):1430-1452
Abdominal Radiology - While the typical imaging features of the more common RCC subtypes have previously been described, they can at times have unusual, but distinguishing features. Rarer renal... 相似文献
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Cesar Homero Gutirrez‐Aguirre Dalila Marisol Alvarado‐Navarro Alain Palomares‐Leal Gerardo Mejía‐Jaramillo Rosario Salazar‐Riojas Andrs Gmez‐De Len Perla Rocío Colunga‐Pedraza Guillermo Sotomayor‐Duque Jos Carlos Jaime‐Prez Olga Graciela Cantú‐Rodríguez Luz del Carmen Tarín‐Arzaga Juan Antonio Flores‐Jimnez David Gmez‐Almaguer 《Transfusion》2019,59(12):3721-3726
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Valeria Cernaro Giuseppe Coppolino Luca Visconti Laura Rivoli Antonio Lacquaniti Domenico Santoro Antoine Buemi Saverio Loddo Michele Buemi 《Medicinal research reviews》2019,39(2):427-460
Erythropoiesis is triggered by hypoxia and is strictly regulated by hormones, growth factors, cytokines, and vitamins to ensure an adequate oxygen delivery to all body cells. Abnormalities in one or more of these factors may induce different kinds of anemia requiring different treatments. A key player in red blood cell production is erythropoietin. It is a glycoprotein hormone, mainly produced by the kidneys, that promotes erythroid progenitor cell survival and differentiation in the bone marrow and regulates iron metabolism. A deficit in erythropoietin synthesis is the main cause of the normochromic normocytic anemia frequently observed in patients with progressive chronic kidney disease. The present review summarizes the most recent findings about each step of the erythropoietic process, going from the renal oxygen sensing system to the cascade of events induced by erythropoietin through its own receptor in the bone marrow. The paper also describes the new class of drugs designed to stabilize the hypoxia-inducible factor by inhibiting prolyl hydroxylase, with a discussion about their metabolism, disposition, efficacy, and safety. According to many trials, these drugs seem able to simulate tissue hypoxia and then stimulate erythropoiesis in patients affected by renal impairment. In conclusion, the in-depth investigation of all events involved in erythropoiesis is crucial to understand anemia pathophysiology and to identify new therapeutic strategies, in an attempt to overcome the potential side effects of the commonly used erythropoiesis-stimulating agents. 相似文献
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Candore G Mantovani V Balistreri CR Lio D Colonna-Romano G Cerreta V Carru C Deiana L Pes G Menardi G Perotti L Miotti V Bevilacqua E Amoroso A Caruso C 《Blood cells, molecules & diseases》2002,29(3):267-273
Genetic hemochromatosis is an autosomal recessive disorder characterized by iron overload and a variety of clinical manifestations such as liver cirrhosis and arthropathy. It is the most common genetic disease of northern European populations. The principal gene responsible for hereditary hemochromatosis, designated HFE, is located on chromosome 6 in the HLA region. The single point mutation 845A, changing cysteine at position 282 to tyrosine (C282Y), in this gene has been identified as the main genetic basis of hereditary hemochromatosis. Two other mutations, 187G, a histidine to aspartate at amino acid 63 (H63D), and 193T, a serine to cysteine at amino acid 65 (S65C), appear to be associated with milder forms of hereditary hemochromatosis. There is a high prevalence of the C282Y mutation in northern European populations, whereas in those of the Mediterranean basin the prevalence seems low and almost absent in Far East countries. This mutation seems usually to occur on the ancestral haplotype 7.1. Accordingly, a Celtic origin of this mutation has been suggested. The aim of this study was to determine the frequency of HFE gene mutations in five geographic regions in Italy. Samples were tested for C282Y, H63D, and S65C mutations of the HFE gene according to methods of each laboratory and the results were standardized with the exchange of typed samples between the different laboratories. In addition, C282Y-positive DNA samples were typed for D6S105 allele 8 and HLA-A3 by ARMS-PCR. We have found that the allele frequency of the C282Y mutation decreases from northeast Italy (Friuli, 6%) to northwest Italy (Piedmont, 4.8%) and to central Italy (Emilia-Romagna, 1.7%). However, this mutation is lacking in the two regions of the Mediterranean basin's center (Sicily and Sardinia). Accordingly, a significant difference in the frequency of the mutation was observed between these Italian regions (P = 0.07 x 10(-3)). In contrast, no difference was observed in allele frequency of H63D in the five Italian regions. Finally, as regards the S65C mutation a very low frequency was observed in Friuli, Emilia-Romagna, and Sardinia, whereas in Sicily and Piedmont we have not found this mutation. In conclusion, these data are consistent with the hypothesis that the C282Y mutation occurred in Caucasian populations of Celtic origin, whereas the H63D mutation is more ancient as demonstrated by the ubiquitous distribution. 相似文献