全文获取类型
收费全文 | 45160篇 |
免费 | 2122篇 |
国内免费 | 374篇 |
专业分类
耳鼻咽喉 | 468篇 |
儿科学 | 816篇 |
妇产科学 | 1299篇 |
基础医学 | 5339篇 |
口腔科学 | 1715篇 |
临床医学 | 3466篇 |
内科学 | 12684篇 |
皮肤病学 | 925篇 |
神经病学 | 3953篇 |
特种医学 | 1191篇 |
外科学 | 6822篇 |
综合类 | 171篇 |
一般理论 | 9篇 |
预防医学 | 2462篇 |
眼科学 | 716篇 |
药学 | 2448篇 |
中国医学 | 114篇 |
肿瘤学 | 3058篇 |
出版年
2024年 | 40篇 |
2023年 | 325篇 |
2022年 | 777篇 |
2021年 | 1471篇 |
2020年 | 791篇 |
2019年 | 1129篇 |
2018年 | 1550篇 |
2017年 | 1018篇 |
2016年 | 1113篇 |
2015年 | 1307篇 |
2014年 | 1792篇 |
2013年 | 2359篇 |
2012年 | 3623篇 |
2011年 | 3570篇 |
2010年 | 2015篇 |
2009年 | 1751篇 |
2008年 | 3042篇 |
2007年 | 3164篇 |
2006年 | 2950篇 |
2005年 | 2917篇 |
2004年 | 2629篇 |
2003年 | 2363篇 |
2002年 | 2083篇 |
2001年 | 278篇 |
2000年 | 193篇 |
1999年 | 292篇 |
1998年 | 367篇 |
1997年 | 322篇 |
1996年 | 288篇 |
1995年 | 279篇 |
1994年 | 219篇 |
1993年 | 164篇 |
1992年 | 144篇 |
1991年 | 104篇 |
1990年 | 105篇 |
1989年 | 86篇 |
1988年 | 65篇 |
1987年 | 60篇 |
1986年 | 73篇 |
1985年 | 71篇 |
1984年 | 74篇 |
1983年 | 65篇 |
1982年 | 95篇 |
1981年 | 66篇 |
1980年 | 72篇 |
1979年 | 42篇 |
1978年 | 48篇 |
1977年 | 38篇 |
1976年 | 35篇 |
1974年 | 29篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
41.
42.
Antonio Vidaller Fernando Guadarrama Luis Llorente Juan Pablo Méndez Fernando Larrea Antonio R. Villa Donato Alarcón-Segovia 《Journal of clinical immunology》1992,12(3):210-215
We studied NK cell function in eight patients with pathological hyperprolactinemia by measuring51Cr release by K562 cells exposed to their mononuclear cells and found it decreased compared to normal controls (P<0.01). Bromocriptine (BrC) treatment corrected NK function but also made it more efficient at 12:1 than at 25:1 or 50:1 effector:target ratios (ANOVA;P=0.01). The study of NK cell function in agarose revealed that its decrease in hyperprolactinemia is due to their low active binding to target cells, active killing, and recycling capacity. BrC tended to correct them but also increased recycling capacity to levels higher than those of controls (P<0.05). Sequential studies in three hyperprolactinemic patients before and after BrC showed correction of NK function within 1 week but its increased efficiency at the 12:1 effector:target ratio required 8 weeks. We conclude that hyperprolactinemia decreases NK cell function. BrC corrects this by decreasing prolactin levels but also makes NK function more efficient by increasing the capacity of NK cells to recycle after killing. 相似文献
43.
44.
Stefano Tamburin Antonio Fiaschi Domenico Idone Piergiorgio Lochner Paolo Manganotti Giampietro Zanette 《Movement disorders》2003,18(11):1316-1324
Hyperexcitability of the motor system has been reported in Parkinson's disease (PD). We evaluate how cutaneous afferents modulate motor excitability in PD patients and whether abnormal modulation is correlated to parkinsonian symptoms. Digital stimulation causes abnormal enhancement of motor responses in patients. This effect may be one of the features of motor hyperexcitability in PD. Cutaneomotor hyperexcitability correlates with clinical scores, suggesting that abnormal processing of cutaneous inputs might contribute to the pathogenesis of parkinsonian symptoms. 相似文献
45.
Eric Vivier Antonio J. da Silva Melissa Ackerly Herbert Levine Christopher E. Rudd Paul Anderson 《European journal of immunology》1993,23(8):1872-1876
The CD16: ζ: γ receptor complex allows natural killer (NK) cells to recognize and eliminate antibody-coated target cells. Whereas the ectodomain of CD16 is the receptor for Fcγ domains of immunoglobulins, disulfide-linked homo- and heterodimers composed of ζ and γ are required for the cell surface expression, and signal transduction properties of the complex. Engagement of CD16 activates the tyrosine kinase pathway, which induces the tyrosine phosphorylation of several substrates, including the ζ subunit and the phospholipase C γ-1 and γ-2 isoforms. Here we show that CD 16 stimulation of either peripheral blood NK cells, leukemic NK cells, or Jurkat transformants expressing a CD16:ζ:γ receptor complex, results in the tyrosine phosphorylation of a 70 kDa ζ-associated protein (pp70). Similarly, a 70-kDa ζ-associated phosphoprotein in T cells has been shown to be a tyrosine kinase (ZAP-70). Peptide mapping analysis indicates that the 70-kDa ζ-associated phosphoproteins from T cells and NK cells are structurally indistinguishable. We conclude that the CD16:ζ:γ complex may use a ZAP-70-related non-receptor tyrosine kinase, in the CD16 signaling cascade leading to NK cell activation. 相似文献
46.
Mutations Affecting the Rossman Fold of Isoleucyl-tRNA Synthetase Are Correlated with Low-Level Mupirocin Resistance in Staphylococcus aureus 下载免费PDF全文
Martin Antonio Neil McFerran Mark J. Pallen 《Antimicrobial agents and chemotherapy》2002,46(2):438-442
The isoleucyl-tRNA synthetase (ileS) gene was sequenced in toto from 9 and in part from 31 Staphylococcus aureus strains with various degrees of susceptibility to mupirocin. All strains for which the mupirocin MIC was greater than 8 microg/ml contained point mutations affecting the Rossman fold via Val-to-Phe changes at either residue 588 (V588F) or residue 631 (V631F). The importance of the V588F mutation was confirmed by an allele-specific PCR survey of 32 additional strains. Additional mutations of uncertain significance were found in residues clustered on the surface of the IleS protein. 相似文献
47.
Antonio F. Govoni M.D 《Clinical imaging》1992,16(4):285
48.
Ana Sánchez-Romero Israel Oliver David Costa Albina Orduña Javier Lacueva Francisco Pérez-Vicente Antonio Arroyo Rafael Calpena 《Clinical & translational oncology》2006,8(4):294-295
Lung cancer is the most prevalent malignancy in western countries and most of the patients present at advanced stages, but
single splenic metastasis is exceptional instead. We report on a case of a seventy-three-year old male presenting with non-hemoptoic
productive cough, constitutional syndrome and pain in the left lower quadrant. Physical examination and complementary radiological
and hystologycal procedures revealed the presence of an adenocarcinoma of the left lung with probable splenic metastasis.
The patient underwent splenectomy, which confirmed the diagnose of splenic metastasis of lung adenocarcinoma and, secondly,
lung resection was performed. Topics about lung cancer metastasis are discussed. 相似文献
49.
Alfonso Fasano Antonio E Elia Arianna Guidubaldi Pietro A Tonali Anna Rita Bentivoglio 《Movement disorders》2007,22(4):564-566
We report a case of cervical dystonia occurring in a 33-year-old without personal history of movement disorder but with family history of essential tremor, primigravid, primiparous woman at 1 weeks' amenorrhea, resolved completely after delivery in the course of 3 months. Dystonia never recurred in the following 5 years. Several neurological disorders are known to occur or worsen during pregnancy. As far as we know, this is the second reported case of dystonia occurring during pregnancy, thus confirming that dystonia gravidarum represents a new entity and should be considered in women of reproductive age affected by dystonia, especially when presenting with rapid-onset cervical dystonia. 相似文献
50.
Paolo Mariotti Alfonso Fasano M Fiorella Contarino Giacomo Della Marca Marco Piastra Orazio Genovese Silvia Pulitanò Antonio Chiaretti Anna Rita Bentivoglio 《Movement disorders》2007,22(7):963-968
Status dystonicus (SD) is a life threatening disorder that develops in patients with both primary and secondary dystonia, characterized by acute worsening of symptoms with generalized and severe muscle contractions. To date, no information is available on the best way to treat this disorder. We review the previously described cases of SD and two new cases are reported, one of which occurring in a child with static encephalopathy, and the other one in a patient with pantothenate kinase-associated neurodegeneration. Both patients were admitted to an intensive care unit and treated with midazolam and propofol. This approach proved to be useful in the former while the progressive nature of the dystonia of the second patient required the combination of intrathecal baclofen infusion and bilateral pallidal deep brain stimulation. We believe that a rapid and aggressive approach is justified to avoid the great morbidity and mortality which characterize SD. Our experience, combined with the data available in the literature, might permit to establish the best strategies in managing this rare and severe condition. 相似文献