全文获取类型
收费全文 | 2375篇 |
免费 | 126篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 53篇 |
妇产科学 | 60篇 |
基础医学 | 301篇 |
口腔科学 | 30篇 |
临床医学 | 143篇 |
内科学 | 672篇 |
皮肤病学 | 14篇 |
神经病学 | 277篇 |
特种医学 | 37篇 |
外科学 | 441篇 |
综合类 | 3篇 |
预防医学 | 96篇 |
眼科学 | 6篇 |
药学 | 84篇 |
中国医学 | 2篇 |
肿瘤学 | 280篇 |
出版年
2023年 | 21篇 |
2022年 | 32篇 |
2021年 | 90篇 |
2020年 | 45篇 |
2019年 | 41篇 |
2018年 | 70篇 |
2017年 | 55篇 |
2016年 | 56篇 |
2015年 | 85篇 |
2014年 | 95篇 |
2013年 | 135篇 |
2012年 | 178篇 |
2011年 | 166篇 |
2010年 | 96篇 |
2009年 | 122篇 |
2008年 | 155篇 |
2007年 | 149篇 |
2006年 | 163篇 |
2005年 | 158篇 |
2004年 | 143篇 |
2003年 | 114篇 |
2002年 | 112篇 |
2001年 | 11篇 |
2000年 | 12篇 |
1999年 | 17篇 |
1998年 | 27篇 |
1997年 | 33篇 |
1996年 | 15篇 |
1995年 | 20篇 |
1994年 | 17篇 |
1993年 | 16篇 |
1992年 | 14篇 |
1991年 | 7篇 |
1990年 | 12篇 |
1989年 | 6篇 |
1988年 | 1篇 |
1987年 | 4篇 |
1986年 | 4篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 1篇 |
1980年 | 4篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1934年 | 1篇 |
1914年 | 1篇 |
排序方式: 共有2524条查询结果,搜索用时 15 毫秒
951.
Sublingual ranula: a closer look to its surgical management 总被引:1,自引:0,他引:1
Mortellaro C Dall'Oca S Lucchina AG Castiglia A Farronato G Fenini E Marenzi G Trosino O Cafiero C Sammartino G 《The Journal of craniofacial surgery》2008,19(1):286-290
Ranulas have been managed by various surgical methods, and the optimal treatment is still controversial. The aim of this study was to analyze a group of 124 surgically treated patients with intraoral ranula to assess 3 different methods: sublingual gland removal combined with the ranula excision, conventional marsupialization, and a variant of the marsupialization technique usually performed in our departments. Recurrence rate was 0% after radical treatment, 25.8% after marsupialization, and 12% after modified marsupialization. We suggest that conservative methods should always be considered as treatment of superficial oral ranulas. The modification of the conventional marsupialization by suturing the edges of the pseudocyst before unroofing of the lesion was demonstrated to be a useful technical strategy that simplifies and accelerates the surgical procedures and probably contributed to preventing recurrences. 相似文献
952.
Francesco Corallo Lilla Bonanno Viviana Lo Buono Simona De Salvo Cettina Allone Rosanna Palmeri Elena La Gattuta Carmela Rifici Antonella Alagna Antonino Todaro Placido Bramanti Silvia Marino 《Neurological sciences》2017,38(7):1249-1253
The aim of this study is to evaluate mood disorders and needs in caregivers of disorders of consciousness (DOC) patients during the admission to Neurorehabilitation Unit. A total of 80 caregivers was enrolled and divided in two groups (caregivers of vegetative state–VS patients and caregivers of minimally conscious state–MCS patients). Paired sample t tests were carried out to test differences between baseline observation (T0) and after 6 months (T1). Caregivers of VS patients showed an improvement between T0 and T1 especially, in vitality, mean health, Beck Depression Inventory (BDI-II), Spielberger State-Trait Anxiety Inventory-Y (STAI-Y), Prolonged Grief Disorder (PG 12) and Caregiver Needs Assessment (CNA). On the other hand, caregivers of MCS patients showed a significant improvement in: BDI II, STAI Y and CNA. These data confirmed that the presence of psychological problems, the quality of life and the psychological wellbeing of caregivers of DOC patients improved over the time. 相似文献
953.
Domenico Albano Nicolò Martinelli Alberto Bianchi Antonino Giacalone Luca Maria Sconfienza 《La Radiologia medica》2017,122(12):909-917
Purpose
To evaluate the applicability and reproducibility of magnetic resonance observation of cartilage repair tissue (MOCART) score for morphological evaluation of osteochondral lesions of the talus (OLT) repaired using autologous matrix-induced chondrogenesis (AMIC) technique.Methods
Two radiologists (R1–R2) and two orthopaedists (O1–O2) independently reviewed 26 ankle MRIs performed on 13 patients (6 females; age: 38.9 ± 15.9, 14–63) with OLT repaired using AMIC. The MRIs were performed at 6 and 12 months from surgery. For inter/intra-observer agreement evaluation for each variable of the MOCART, we used Cohen’s kappa coefficient. Progression of MOCART between 6- and 12-month evaluation was assessed using the Wilcoxon test. The Spearman’s correlation coefficient was used to evaluate the correlation between baseline lesion size and MOCART.Results
The inter-observer agreement between R1 and R2 ranged from poor (adhesions, k = 0.124) to almost perfect (subchondral bone, k = 0.866), between O1 and O2 from absent (effusion, k = ?0.190) to poor (surface, k = 0.172), and between R1 and O1 from absent (cartilage interface, k = ?0.324) to fair (signal intensity, k = 0.372). The intra-observer agreement of R1 ranged from poor (signal intensity, k = 0.031) to substantial (subchondral lamina, k = 0.677), while that of O1 from absent (subchondral bone, k = ?0.061) to substantial (surface, k = 0.663). There was a significant increase of MOCART between 6- and 12-month evaluation of R1 (Z = ?2.672; P = 0.008), R2 (Z = ?2.721; P = 0.007) and O1 (Z = ?3.034; P = 0.002). Conversely, the increase of MOCART of O2 was not significant (Z = ?1.665; P = 0.096). Inverse correlation between lesion size at baseline and MOCART was significant at 12-month evaluation (?0.726; P = 0.005).Conclusion
MRI has an important role in the follow-up of surgical repaired OLT, but MOCART score does not seem to be sufficiently reproducible to be applied for this purpose.954.
Sandrine Chamayou Maria Sicali Carmelita Alecci Carmen Ragolia Annalisa Liprino Daniela Nibali Giorgia Storaci Antonietta Cardea Antonino Guglielmino 《Journal of assisted reproduction and genetics》2017,34(4):479-486
Purpose
In a preimplantation genetic diagnosis for aneuploidy (PGD-A) program, the more embryos available for biopsy, consequently increases the chances of obtaining euploid embryos to transfer. The aim was to increase the number of viable euploid blastocysts in patients undergoing PGD-A using fresh oocytes together with previously accumulated vitrified oocytes.Methods
Sixty-nine patients with normal ovarian reserve underwent PGD-A for repeated implantation failure or recurrent pregnancy loss indication. After several cycles of ovarian stimulation, 591 accumulated vitrified oocytes and 463 fresh oocytes were micro-injected with the same partner’s semen sample. PGD-A was completed on 134 blastocysts from vitrified/warmed oocytes and 130 blastocysts from fresh oocytes.Results
A mean of 9.6% euploid blastocyst per micro-injected vitrified/warmed oocytes and 11.4% euploid blastocyst per micro-injected fresh oocyte were obtained (p?>?0.05). The euploidy and aneuploidy rates were comparable in blastocysts obtained from micro-injected vitrified/warmed oocytes and fresh oocytes (42.5 versus 40.8% and 57.5 versus 59.2%, p?>?0.05). Implantation rates of euploid blastocysts were comparable between the two sources of oocytes (56.0% from vitrified/warmed oocytes versus 60.9% from fresh oocytes, p?>?0.05).Conclusions
Oocyte vitrification and warming do not generate aneuploidy in blastocysts. The number of viable euploid embryos for transfer can be increased by using accumulated vitrified oocytes together with fresh oocytes in ICSI.Trial registration
NCT02820415 ClinicalTrials.gov955.
Mirko Bertozzi Ciro Esposito Claudio Vella Vito Briganti Nicola Zampieri Daniela Codrich Michele Ubertazzi Alessandro Trucchi Elisa Magrini Sonia Battaglia Vittorio Bini Maria Luisa Conighi Caterina Gulia Alessandra Farina Francesco Saverio Camoglio Waifro Rigamonti Piergiorgio Gamba Giovanna Riccipetitoni Antonino Appignani 《Journal of pediatric and adolescent gynecology》2017,30(3):413-417
Study Objective
To report results of a retrospective multicentric Italian survey concerning the management of pediatric ovarian torsion (OT) and its recurrence.Design
Multicenter retrospective cohort study.Setting
Italian Units of Pediatric Surgery.Participants
Participants were female aged 1-14 years of age with surgically diagnosed OT between 2004 and 2014.Interventions
Adnexal detorsion, adnexectomy, mass excision using laparoscopy or laparotomy. Different kinds of oophoropexy (OPY) for OT or recurrence, respectively.Main Outcome Measures
A total of 124 questionnaires were returned and analyzed to understand the current management of pediatric OT and its recurrence. The questionnaires concerned patient age, presence of menarche, OT site, presence and type of mass, performed procedure, OPY technique adopted, intra- and postoperative complications, recurrence and site, procedure performed for recurrence, OPY technique for recurrence, and 1 year follow-up of detorsed ovaries.Results
Mean age at surgery was 9.79 ± 3.54 years. Performed procedures were open adnexectomy (52 of 125; 41.6%), laparoscopic adnexectomy (25 of 125; 20%), open detorsion (10 of 125; 8%), and laparoscopic detorsion (38 of 125; 30.4%). Recurrence occurred in 15 of 125 cases (12%) and resulted as significant (P = .012) if associated with a normal ovary at the first episode of torsion. Recurrence occurred only in 1 of 19 cases after OPY (5.2%). Ultrasonographic results of detorsed ovaries were not significant whether an OPY was performed or not (P = 1.00).Conclusion
Unfortunately, oophorectomy and open technique are still widely adopted even if not advised. Recurrence is not rare and the risk is greater in patients without ovarian masses. OPY does not adversely affect ultrasonographic results at 1 year. When possible OPY should be performed at the first episode of OT. 相似文献956.
Gallina A Ferrari M Suardi N Capitanio U Abdollah F Tutolo M Bianchi M Saccà A Salonia A Rigatti P Montorsi F Briganti A 《The journal of sexual medicine》2012,9(3):903-908
IntroductionSeveral studies have shown that erectile function (EF) recovery in patients undergoing bilateral nerve sparing radical prostatectomy (BNSRP) improves significantly when phosphodiesterase type 5 inhibitors (PDE5) are administered following surgery.AimThe aim of this article was to identify patients who may recover EF after retropubic BNSRP (BNSRRP) without PDE5.MethodsWe included 293 patients treated with BNSRRP at a single center. Postoperative EF recovery was defined as an EF domain score of the International Index of Erectile Function (IIEF) ≥22. No patient received any treatment for postoperative erectile dysfunction (ED). Kaplan–Meier curves assessed time to EF recovery according to patient age, preoperative EF, and Charlson comorbidity index (CCI). Univariable and multivariable Cox regression models tested the association between predictors and EF recovery. Finally, the rate of EF recovery of untreated patients after BNSRP was compared with a subset of patients with similar preoperative characteristics but receiving PDE5.Main Outcome MeasureThe main outcome measure of this article was the IIEF‐EF domain score.ResultsOverall, 105/293 (35.8%) reached an IIEF‐EF ≥22 after a mean follow‐up of 26.8 months. At multivariable analyses, age, preoperative IIEF‐EF, and CCI achieved independent predictor status (all P ≤ 0.04). Patients <55 years had a 72.4% EF recovery rate compared with 30% of patients >70 years (P < 0.001). Similarly, preoperatively fully potent patients (IIEF‐EF ≥26) had a 56.6% chance of recovering EF after surgery compared with 18% of patients with severe ED before surgery (P < 0.001). The rate of EF recovery in untreated patients <55 years and with a pre‐op IIEF‐EF ≥22 was higher but did not differ significantly from comparable patients receiving PDE5 (P = 0.11).ConclusionsOverall, the rate of EF postoperative recovery in patients left untreated after surgery is modest (35.8%). Although younger patients with a good preoperative EF may experience good EF recovery rates even without any treatment, use of PDE5 after surgery further improved their functional outcomes. Therefore, a therapy for ED should be offered to all patients treated with BNSRP. Gallina A, Ferrari M, Suardi N, Capitanio U, Abdollah F, Tutolo M, Bianchi M, Saccà A, Salonia A, Rigatti P, Montorsi F, and Briganti A. Erectile function outcome after bilateral nerve sparing radical prostatectomy: Which patients may be left untreated? J Sex Med 2012;9:903–908. 相似文献
957.
958.
959.
Martire B Rondelli R Soresina A Pignata C Broccoletti T Finocchi A Rossi P Gattorno M Rabusin M Azzari C Dellepiane RM Pietrogrande MC Trizzino A Di Bartolomeo P Martino S Carpino L Cossu F Locatelli F Maccario R Pierani P Putti MC Stabile A Notarangelo LD Ugazio AG Plebani A De Mattia D;IPINET 《Clinical immunology (Orlando, Fla.)》2008,126(2):155-164
A retrospective clinical and immunological survey was conducted in 60 patients with Chronic Granulomatous Disease. A prospective controlled non-randomized study of the efficacy of long-term IFNgamma treatment was carried out. The mean age at the time of diagnosis was 4.4 years; mean duration of follow-up was 10.4 years. Lung and skin infections were the most frequent manifestations both prior to diagnosis and during follow-up. Aspergillus species was the first cause of infection and of death in our cohort. The mortality rate was 13%. Long term prophylaxis with IFNgamma did not significantly change the rate of total infection per patient-year compared to controls (p=0.07). Our data provide clear evidence that protocols of continuing intensive surveillance and monitoring of compliance with anti-infective regimens may significantly improve the quality of life and long-term survival in patients with CGD. No evidence justifying long-term prophylaxis with IFNgamma was obtained. 相似文献
960.
Perceptual load affects exogenous spatial orienting while working memory load does not 总被引:1,自引:0,他引:1
Santangelo V Finoia P Raffone A Belardinelli MO Spence C 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2008,184(3):371-382
We examined whether or not increasing visual perceptual load or visual working memory (WM) load would affect the exogenous
orienting of visuo-spatial attention, in order to assess whether or not exogenous orienting is genuinely automatic. In Experiment
1, we manipulated visual perceptual load by means of a central morphing shape that in some trials morphed into a particular
target shape (a rectangle) that participants had to detect. In Experiment 2, the possibility that the presentation of any
changing stimulus at fixation would eliminate exogenous orienting was ruled out, by presenting two alternating letters at
fixation. In Experiment 3, we manipulated visual WM load by means of arrays consisting of three (low-load) or five (high-load)
randomly located coloured squares. The participants had to remember these items in order to judge whether a cued square had
been presented in the same or different colour at the end of each trial. In all the experiments, exogenous visuo-spatial attentional
orienting was measured by means of an orthogonal spatial cuing task, in which the participants had to discriminate the elevation
(up vs. down) of a visual target previously cued by a spatially nonpredictive visual cue. The results showed that increasing
the perceptual load of the task eliminated the exogenous orienting of visuo-spatial attention. By contrast, increasing the
WM load had no effect on spatial orienting. These results are discussed in terms of the light that they shed on claims regarding
the automaticity of visuo-spatial exogenous orienting.
相似文献
Valerio SantangeloEmail: |