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排序方式: 共有516条查询结果,搜索用时 15 毫秒
21.
Angelo Andriulli Vito Di Marco Maurizio Margaglione Antonio Massimo Ippolito Giovanna Fattovich Antonina Smedile Maria Rosa Valvano Vincenza Calvaruso Domenica Gioffreda Michele Milella Filomena Morisco Martina Felder Giuseppina Brancaccio Massimo Fasano Pietro Gatti Paolo Tundo Michele Barone Raffaele Cozzolongo Mario Angelico Giovanna D’Andrea Nicola Andriulli Maria Lorena Abate Giuseppe Mazzella Giovanni Battista Gaeta Antonio Craxi Teresa Santantonio 《Journal of hepatology》2014
22.
Todd B. Kashdan Leah M. Adams Antonina S. Farmer Patty Ferssizidis Patrick E. McKnight John B. Nezlek 《Archives of sexual behavior》2014,43(7):1417-1429
A growing literature attests to deficits in social and romantic life quality in people with elevated social anxiety, but no research to date has explored how intense intimate encounters influence social anxiety symptoms. This study investigated whether the presence and quality of sexual activity on a given day predicted less social anxiety and negative cognitions on a subsequent day. We also explored whether the benefits of sexual activity would be stronger for more socially anxious individuals. Over 21 days, 172 undergraduate students described the presence and quality of sexual activity, social anxiety symptoms, and use of social comparisons on the day in question. Time-lagged analyses determined that being sexually active on one day was related to less social anxiety symptoms and the generation of fewer negative social comparisons the next day. Furthermore, more intense experiences of pleasure and connectedness during sex predicted greater reductions in social anxiety the next day for people high in trait social anxiety, compared to those low in trait social anxiety. These results were similar regardless of whether sex occurred in the context of romantic relationships or on weekdays versus weekends. The results suggest that sexual activity, particularly when pleasurable and intimate, may mitigate some of the social anxiety and negative comparisons frequently experienced by people with high trait social anxiety. 相似文献
23.
Romina Vuono PhD Antonina Kouli MSc Emilie M. Legault BSc Lauriane Chagnon DEC Kieren S. Allinson FRCPath Alberto La Spada BSc REGISTRY Investigators of the European Huntington's Disease Network Ida Biunno PhD Roger A. Barker MRCP PhD Janelle Drouin-Ouellet PhD 《Movement disorders》2020,35(3):401-408
24.
Theodosiou Z Kasampalidis IN Karayannopoulou G Kostopoulos I Bobos M Bevilacqua G Aretini P Starita A Lyroudia K Pitas I 《Breast (Edinburgh, Scotland)》2008,17(1):80-84
HER2-positive breast cancer is characterized by aggressive growth and poor prognosis. Women with metastatic breast cancer with over-expression of HER2 protein or excessive presence of HER2 gene copies are potential candidates for Herceptin (Trastuzumab) targeted treatment that binds to HER2 receptors on tumor cells and inhibits tumor cell growth. Fluorescence in situ hybridization (FISH) is one of the most widely used methods to determine HER2 status. Typically, evaluation of FISH images involves manual counting of FISH signals in multiple images, a time consuming and error prone procedure. Recently, we developed novel software for the automated evaluation of FISH images and, in this study, we present the first testing of this software on images from two separate research clinics. To our knowledge, this is the first concurrent evaluation of any FISH image analysis software in two different clinics. The evaluation shows that the developed FISH image analysis software can accelerate evaluation of HER2 status in most breast cancer cases. 相似文献
25.
Santagati A Granata G Santagati M Cutuli V Mangano NG Caruso A 《Arzneimittel-Forschung》2002,52(6):448-454
The synthesis, the analgesic and anti-inflammatory activities of two series of phenyl derivatives containing 5,6-dimethyl-thieno[2,3-d]pyrimidin-4(1H)-one and 4H-pyrimido[5,4-b]indol-4-one system, respectively, are reported. Two of these derivatives, 6A and 9B, showed interesting activities. The results of the pharmacological assays are discussed. 相似文献
26.
27.
Furneri PM Marino A Saija A Uccella N Bisignano G 《International journal of antimicrobial agents》2002,20(4):293-296
The activity of oleuropein, a phenolic glycoside contained in olive oil, was investigated in vitro against Mycoplasma hominis, Mycoplasma fermentans, Mycoplasma pneumoniae and Mycoplasma pirum. Oleuropein inhibited mycoplasmas at concentrations from 20 to 320 mg/l. The MICs of oleuropein to M. pneumoniae, M. pirum, M. hominis and M. fermentans were 160, 320, 20 and 20 mg/l, respectively. 相似文献
28.
29.
Frolov VA Lizunov VA Dunina-Barkovskaya AY Samsonov AV Zimmerberg J 《Proceedings of the National Academy of Sciences of the United States of America》2003,100(15):8698-8703
Shape dynamics and permeability of a membrane neck connecting a vesicle and plasma membrane are considered. The neck is modeled by a lipid membrane tubule extended between two parallel axisymmetric rings. Within a range of lengths, defined by system geometry and mechanical properties of the membrane, the tubule has two stable shapes: catenoidal microtubule and cylindrical nanotubule. The permeabilities of these two shapes, measured as ionic conductivity of the tubule interior, differ by up to four orders of magnitude. Near the critical length the transitions between the shapes occur within less than a millisecond. Theoretical estimates show that the shape switching is controlled by a single parameter, the tubule length. Thus the tubule connection can operate as a conductivity microswitch, toggling the release of vesicle content in such cellular processes as "kiss-and-run" exocytosis. In support of this notion, bistable behavior of membrane connections between vesicles and the cell plasma membrane in macrophages is demonstrated. 相似文献
30.
Pignatello R Montenegro L Stancampiano AH Puleo A Puglisi G 《Current drug delivery》2005,2(2):185-189
Novel amide conjugates of the NSAID naproxen (NAP, 1) with short-chain alpha-alkylamino acids (C4 to C6 alkyl chain) were synthesized through a carbodiimide (EDAC)-assisted coupling reaction and evaluated as dermal prodrugs of NAP. The 2-alpha-aminobutyl derivative (2) showed lipophilicity similar to that of NAP, while the higher homologues (3) and (4) were more lipophilic than the parent drug, as assessed by CLogP and HPLC methods. The chemical and enzymatic hydrolysis of these compounds was evaluated in aqueous buffer solution (pH 7.4) and 80% human plasma. All compounds showed a good chemical stability (t1/2 = 88-133 h) but underwent a rapid enzymatic hydrolysis to NAP (t1/2 around 3 h). The bioconversion of prodrugs into NAP was confirmed by an in vivo test, since i.p. administration of compounds 2-4 to mice gave a similar analgesic response than the parent drug. In vitro skin permeation experiments were performed using adult human SCE samples mounted in Franz-type diffusion cells. The butyl derivative 2 that showed an increased aqueous solubility compared to NAP gave a 5-fold improvement of skin permeation compared to NAP. In conclusion, the conjugate 2 could be regarded as a good candidate to improve NAP topical delivery and will be further studied as a prodrug for topical administration of this drug. 相似文献