全文获取类型
收费全文 | 6053篇 |
免费 | 387篇 |
国内免费 | 45篇 |
专业分类
耳鼻咽喉 | 29篇 |
儿科学 | 152篇 |
妇产科学 | 167篇 |
基础医学 | 1006篇 |
口腔科学 | 79篇 |
临床医学 | 500篇 |
内科学 | 1597篇 |
皮肤病学 | 276篇 |
神经病学 | 575篇 |
特种医学 | 142篇 |
外科学 | 455篇 |
综合类 | 12篇 |
一般理论 | 2篇 |
预防医学 | 355篇 |
眼科学 | 36篇 |
药学 | 374篇 |
中国医学 | 26篇 |
肿瘤学 | 702篇 |
出版年
2024年 | 6篇 |
2023年 | 54篇 |
2022年 | 148篇 |
2021年 | 208篇 |
2020年 | 118篇 |
2019年 | 174篇 |
2018年 | 199篇 |
2017年 | 131篇 |
2016年 | 151篇 |
2015年 | 202篇 |
2014年 | 257篇 |
2013年 | 300篇 |
2012年 | 465篇 |
2011年 | 527篇 |
2010年 | 287篇 |
2009年 | 241篇 |
2008年 | 399篇 |
2007年 | 387篇 |
2006年 | 424篇 |
2005年 | 373篇 |
2004年 | 350篇 |
2003年 | 304篇 |
2002年 | 292篇 |
2001年 | 30篇 |
2000年 | 23篇 |
1999年 | 41篇 |
1998年 | 57篇 |
1997年 | 58篇 |
1996年 | 49篇 |
1995年 | 47篇 |
1994年 | 34篇 |
1993年 | 30篇 |
1992年 | 17篇 |
1991年 | 15篇 |
1990年 | 12篇 |
1989年 | 17篇 |
1988年 | 13篇 |
1987年 | 6篇 |
1986年 | 6篇 |
1985年 | 4篇 |
1984年 | 7篇 |
1983年 | 4篇 |
1981年 | 6篇 |
1980年 | 4篇 |
1979年 | 3篇 |
1977年 | 4篇 |
1974年 | 1篇 |
排序方式: 共有6485条查询结果,搜索用时 31 毫秒
71.
Immacolata Andolfo Roberta Russo Antonella Gambale Achille Iolascon 《American journal of hematology》2018,93(1):107-121
Hereditary stomatocytoses are a wide class of hemolytic anemias characterized by alterations of ionic flux with increased cation permeability that results in inappropriate shrinkage or swelling of the erythrocytes, and water lost or gained osmotically. The last few years have been crucial for new acquisitions in this field in terms of identifying new causative genes and of studying their pathogenetic mechanisms. This review summarizes the main features of erythrocyte membrane transport diseases, dividing them into forms with either isolated erythroid phenotype (nonsyndromic) or extra‐hematological manifestations (syndromic), and focusing particularly on the most recent advances regarding dehydrated forms of hereditary stomatocytosis and familial pseudohyperkalemia. 相似文献
72.
73.
Cynthia Aristei Valentina Lancellotta Marco Piergentini Giacomo Costantini Simonetta Saldi Sara Chierchini Antonella Cavalli Luca Di Renzo Oscar Fiorucci Massimo Guasticchi Vittorio Bini Alessandro Ricci 《Brachytherapy》2019,18(1):57-62
Purpose
High-dose-rate, multicatheter interstitial brachytherapy is technically complex and operator-dependent, requiring lengthy training and specialized skills. Furthermore, until the advent of contouring on computerized tomography (CT) images, difficulties existed in locating the target volume precisely. The present article reports the results of a study that aimed at producing and validating a 3D-printed template to aid in target volume localization for multicatheter interstitial brachytherapy in patients with breast cancer.Methods and Materials
Thirteen patients, candidates for accelerated partial breast irradiation or boost, were enrolled in the study. The target volume was defined on CT slices, and a template with empty spaces corresponding to the target volume projection on the patient's skin was produced by a 3D printer. The procedure was compared with the standard method followed in our center (1) visually, by assessing overlap between the target volume projections on the patient's skin, (2) by X-ray findings, and (3) by intraclass correlation coefficient.Results
Visual assessment and X-ray findings showed the 3D-printed target volume always fell within the standard volume in all 13 patients. The intraclass correlation coefficient indicated moderate agreement for both the medial and the lateral skin projections.Conclusions
The 3-D printed templates constitute a quick, easy, and reliable method to localize the target volume for high-dose-rate interstitial multicathether brachytherapy in patients with breast cancer and can safely be used in clinical practice. 相似文献74.
Gaspare Palaia Alessandra Impellizzeri Gianluca Tenore Federico Caporali Paolo Visca Alessandro Del Vecchio Gabriella Galluccio Antonella Polimeni Umberto Romeo 《Clinical oral investigations》2020,24(8):2645-2652
The aim of this study was to evaluate, ex vivo, the histological effects of 445-nm diode laser (Eltech K-Laser srl, Treviso, Italy), during an oral soft ti 相似文献
75.
76.
Antonio Nieto Ulrich Wahn Albrecht Bufe Philippe Eigenmann Susanne Halken Gunilla Hedlin Arne Høst Jonathan Hourihane Jocelyne Just Gideon Lack Susanne Lau Paolo Maria Matricardi Antonella Muraro Nikos Papadopoulos Graham Roberts Angela Simpson Erkka Valovirta Stephan Weidinger Magnus Wickman Angel Mazon 《Pediatric allergy and immunology》2014,25(6):516-533
77.
Susanne Halken Desiree Larenas‐Linnemann Graham Roberts Moises A. Calderón Elisabeth Angier Oliver Pfaar Dermot Ryan Ioana Agache Ignacio J. Ansotegui Stefania Arasi George Du Toit Montserrat Fernandez‐Rivas Roy Geerth van Wijk Marek Jutel Jörg Kleine‐Tebbe Susanne Lau Paolo M. Matricardi Giovanni B. Pajno Nikolaos G. Papadopoulos Martin Penagos Alexandra F. Santos Gunter J. Sturm Frans Timmermans R. van Ree Eva‐Maria Varga Ulrich Wahn Maria Kristiansen Sangeeta Dhami Aziz Sheikh Antonella Muraro 《Pediatric allergy and immunology》2017,28(8):728-745
Allergic diseases are common and frequently coexist. Allergen immunotherapy (AIT) is a disease‐modifying treatment for IgE‐mediated allergic disease with effects beyond cessation of AIT that may include important preventive effects. The European Academy of Allergy and Clinical Immunology (EAACI) has developed a clinical practice guideline to provide evidence‐based recommendations for AIT for the prevention of (i) development of allergic comorbidities in those with established allergic diseases, (ii) development of first allergic condition, and (iii) allergic sensitization. This guideline has been developed using the Appraisal of Guidelines for Research & Evaluation (AGREE II) framework, which involved a multidisciplinary expert working group, a systematic review of the underpinning evidence, and external peer‐review of draft recommendations. Our key recommendation is that a 3‐year course of subcutaneous or sublingual AIT can be recommended for children and adolescents with moderate‐to‐severe allergic rhinitis (AR) triggered by grass/birch pollen allergy to prevent asthma for up to 2 years post‐AIT in addition to its sustained effect on AR symptoms and medication. Some trial data even suggest a preventive effect on asthma symptoms and medication more than 2 years post‐AIT. We need more evidence concerning AIT for prevention in individuals with AR triggered by house dust mites or other allergens and for the prevention of allergic sensitization, the first allergic disease, or for the prevention of allergic comorbidities in those with other allergic conditions. Evidence for the preventive potential of AIT as disease‐modifying treatment exists but there is an urgent need for more high‐quality clinical trials. 相似文献
78.
Cindy L. Cain Antonella Surbone Ronit Elk Marjorie Kagawa-Singer 《Journal of pain and symptom management》2018,55(5):1408-1419
Palliative care is gaining acceptance across the world. However, even when palliative care resources exist, both the delivery and distribution of services too often are neither equitably nor acceptably provided to diverse population groups. The goal of this study was to illustrate tensions in the delivery of palliative care for diverse patient populations to help clinicians to improve care for all. We begin by defining and differentiating culture, race, and ethnicity, so that these terms—often used interchangeably—are not conflated and are more effectively used in caring for diverse populations. We then present examples from an integrative literature review of recent research on culture and palliative care to illustrate both how and why varied responses to pain and suffering occur in different patterns, focusing on four areas of palliative care: the formation of care preferences, communication patterns, different meanings of suffering, and decision-making processes about care. For each area, we provide international and multiethnic examples of variations that emphasize the need for personalization of care and the avoidance of stereotyping beliefs and practices without considering individual circumstances and life histories. We conclude with recommendations for improving palliative care research and practice with cultural perspectives, emphasizing the need to work in partnerships with patients, their family members, and communities to identify and negotiate culturally meaningful care, promote quality of life, and ensure the highest quality palliative care for all, both domestically and internationally. 相似文献
79.
80.
Sveva Grande Alessandra Palma Anna Maria Luciani Antonella Rosi Laura Guidoni Vincenza Viti 《NMR in biomedicine》2011,24(1):68-79
The glycosylation process, through the addition of carbohydrates, is a major post‐translational modification of proteins and glycolipids. Proteins may be glycosylated in either the secretory pathway leading to N‐linked or O‐linked glycoproteins or as nucleocytoplasmic glycosylation that targets only single proteins involving a single β‐linked N‐acetylglucosamine. In both cases, the key precursors are the uridine diphospho‐N‐acetylhexosamines synthesised by the hexosamine biosynthetic pathway. Furthermore, uridine diphospho‐N‐acetylglucosamine participates in the biosynthesis of sialic acid. In this work, we propose MRS for the detection of uridine diphospho‐N‐acetylhexosamines visible in high‐resolution MR spectra of intact cells from different human tumours. Signals from the nucleotide and amino sugar moieties, including amide signals observed for the first time in whole cells, are assigned, also taking advantage of spectral changes that follow cell treatment with ammonium chloride. Finally, parallel changes in uridine diphospho‐N‐acetylhexosamines and glutamine pools, observed after pH changes induced by ammonium chloride in the different tumour cell lines, may provide more details on the glycosylation processes. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献