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91.
Stalo Papoutsou George Briassoulis Charalambos Hadjigeorgiou Savvas C. Savva Tonia Solea Antje Hebestreit 《International journal of food sciences and nutrition》2014,65(3):273-279
The aim of this study was to investigate the association of breakfast consumption with children’s diet quality and cardiometabolic risk factors. Study sample consisted of 1558 children aged 4–8 years from Cyprus. Breakfast frequency was assessed through a parental questionnaire. Body mass index (BMI), BMI z-scores, waist circumference, blood lipid profile and blood pressure were examined in relation to breakfast frequency consumption. Habitual breakfast consumers’ daily nutrient intake was assessed through a 24-Hour Dietary Recall, according to their breakfast choices. Girls who have breakfast on a daily basis had lower mean BMI and BMI z-score; they were also less likely of having abnormal levels of serum triglycerides, atheromatic index (total cholesterol to high density lipoprotein-cholesterol ratio) and diastolic blood pressure after controlling for several confounding factors. Within regular breakfast consumers, of both boys and girls, those having ready to eat cereals had a superior nutrient intake profile. Daily breakfast consumption along with good breakfast choices is an important public health message for Cypriot children. 相似文献
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Alexander Gröbe Henning Hanken Ahmed Al-Dam Georg Cachovan Ralf Smeets Antje Krohn Till Clauditz Tobias Grob Ronald Simon Guido Sauter Lan Kluwe Max Heiland Marco Blessmann 《Clinical oral investigations》2014,18(1):211-217
Objectives
The present study aims to investigate the relevance of immunohistochemical p53 expression in carcinomas of the oral cavity and of the head and neck region. Long-term clinical and histopathological follow-up findings as well as HPV status are correlated with the results of this examination.Materials and methods
Sections made from two tissue arrays composed of 222 oral squamous cell carcinomas and 427 squamous cell carcinomas of the head and neck region, respectively, were examined for p53 expression and Ki-67 index by means of immunohistochemistry. Correlation of long-term clinical findings of the patients and pathological features of tumours with laboratory results were examined statistically.Results
No significant correlation was found between the p53 immunohistochemical expression in the 207 oral carcinomas and features of the tumours and patient outcomes. There was no significant association between the Ki-67 labelling index and the p53 expression.Discussion
Our failure in detecting any association of the p53 immunohistochemical expression regardless of HPV status with clinical features of these tumours suggests it lacks a prognostic value for squamous cell carcinomas of the oral cavity.Clinical relevance
The prognostic value of p53 immunostaining in oral squamous carcinoma is not clarified yet. In the present study, there is no impact on any prognostical item nor even a correlation with cell proliferation (Ki-67) regardless of HPV status. 相似文献95.
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97.
Nicholas T. H. Farr Sabiniano Roman Jan Schfer Antje Quade Daniel Lester Vanessa Hearnden Sheila MacNeil Cornelia Rodenburg 《RSC advances》2021,11(55):34710
Polypropylene (PP) surgical mesh, used successfully for the surgical repair of abdominal hernias, is associated with serious clinical complications when used in the pelvic floor for repair of stress urinary incontinence or support of pelvic organ prolapse. While manufacturers claim that the material is inert and non-degradable, there is a growing body of evidence that asserts PP fibres are subject to oxidative damage and indeed explanted material from patients suffering with clinical complications has shown some evidence of fibre cracking and oxidation. It has been proposed that a pathological cellular response to the surgical mesh contributes to the medical complications; however, the mechanisms that trigger the specific host response against the material are not well understood. Specifically, this study was constructed to investigate the mechano–chemical effects of oxidation and dynamic distension on polypropylene surgical mesh. To do this we used a novel advanced spectroscopical characterisation technique, secondary electron hyperspectral imaging (SEHI), which is based on the collection of secondary electron emission spectra in a scanning electron microscope (SEM) to reveal mechanical–chemical reactions within PP meshes.The application of novel SEM-based spectroscopical characterisation techniques reveals the mechano–chemical effects of oxidation and dynamic distension on polypropylene surgical mesh. 相似文献
98.
Bührer Christoph Ensenauer Regina Jochum Frank Kalhoff Hermann Körner Antje Koletzko Berthold Lawrenz Burkhard Mihatsch Walter Rudloff Silvia Zimmer Klaus-Peter 《Monatsschrift für Kinderheilkunde》2020,168(9):834-841
Monatsschrift Kinderheilkunde - Eine adäquate Energie- und Nährstoffversorgung ist Grundlage für ein gesundes Wachstum und Voraussetzung für die Erhaltung von Gesundheit und... 相似文献
99.
Judith A. Stolwijk Lisa Sauer Kirsten Ackermann Anaïs Nassios Thiha Aung Silke Haerteis Antje J. Bäumner Joachim Wegener Stephan Schreml 《Experimental dermatology》2020,29(11):1055-1061
Solid tumors exhibit an inversed pH gradient with increased intracellular pH (pHi) and decreased extracellular pH (pHe). This inside-out pH gradient is generated via sodium/hydrogen antiporter 1, vacuolar-type H + ATPases, monocarboxylate transporters, (bi)carbonate (co)transporters and carboanhydrases. Our knowledge on how pHe-signals are sensed and what the respective receptors induce inside cells is scarce. Some pH-sensitive receptors (GPR4, GPR65/TDAG8, GPR68/OGR1, GPR132/G2A, possibly GPR31 and GPR151) and ion channels (acid-sensing ion channels ASICs, transient receptor potential vanilloid receptors TRPVs) transduce signals inside cells. As little is known on the expression and function of these pH sensors, we used immunostainings to study tissue samples from common and rare skin cancers. Our current and future work is directed towards investigating the impact of all the pH-sensing receptors in different skin tumors using cell culture techniques with selective knockdown/knockout (siRNA/CRISPR-Cas9). To study cell migration and proliferation, novel impedance-based wound healing assays have been developed and are used. The field of pH sensing in tumors and wounds holds great promise for the development of pH-targeting therapies, either against pH regulators or sensors to inhibit cell proliferation and migration. 相似文献
100.
Giede-Jeppe Antje Madžar Dominik Sembill Jochen A. Sprügel Maximilian I. Atay Selim Hoelter Philip Lücking Hannes Huttner Hagen B. Bobinger Tobias 《Neurocritical care》2020,33(1):97-104
Neurocritical Care - Inflammatory response is the hallmark of secondary brain injury in stroke patients. Neutrophil-to-lymphocyte ratio (NLR) emerged as a marker for functional outcome in several... 相似文献