全文获取类型
收费全文 | 2147篇 |
免费 | 161篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 55篇 |
儿科学 | 83篇 |
妇产科学 | 29篇 |
基础医学 | 458篇 |
口腔科学 | 42篇 |
临床医学 | 186篇 |
内科学 | 323篇 |
皮肤病学 | 42篇 |
神经病学 | 338篇 |
特种医学 | 70篇 |
外科学 | 171篇 |
综合类 | 6篇 |
一般理论 | 2篇 |
预防医学 | 132篇 |
眼科学 | 62篇 |
药学 | 114篇 |
中国医学 | 4篇 |
肿瘤学 | 195篇 |
出版年
2023年 | 21篇 |
2022年 | 27篇 |
2021年 | 46篇 |
2020年 | 51篇 |
2019年 | 38篇 |
2018年 | 51篇 |
2017年 | 37篇 |
2016年 | 66篇 |
2015年 | 72篇 |
2014年 | 87篇 |
2013年 | 108篇 |
2012年 | 158篇 |
2011年 | 155篇 |
2010年 | 101篇 |
2009年 | 112篇 |
2008年 | 151篇 |
2007年 | 138篇 |
2006年 | 129篇 |
2005年 | 136篇 |
2004年 | 115篇 |
2003年 | 128篇 |
2002年 | 111篇 |
2001年 | 32篇 |
2000年 | 32篇 |
1999年 | 24篇 |
1998年 | 30篇 |
1997年 | 21篇 |
1996年 | 18篇 |
1995年 | 8篇 |
1994年 | 10篇 |
1993年 | 10篇 |
1992年 | 7篇 |
1991年 | 7篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 6篇 |
1987年 | 8篇 |
1986年 | 2篇 |
1982年 | 2篇 |
1980年 | 3篇 |
1971年 | 2篇 |
1955年 | 4篇 |
1946年 | 2篇 |
1939年 | 2篇 |
1938年 | 2篇 |
1934年 | 3篇 |
1927年 | 3篇 |
1925年 | 3篇 |
1922年 | 2篇 |
1902年 | 1篇 |
排序方式: 共有2312条查询结果,搜索用时 0 毫秒
71.
72.
73.
74.
75.
Nasal Staphylococcus aureus carriage is not a risk factor for lower-airway infection in young cystic fibrosis patients 下载免费PDF全文
Ridder-Schaphorn S Ratjen F Dübbers A Häberle J Falk S Küster P Schuster A Mellies U Löwe B Reintjes R Peters G Kahl BC 《Journal of clinical microbiology》2007,45(9):2979-2984
Staphylococcus aureus is one of the first pathogens which often persistently infect the airways of cystic fibrosis (CF) patients. Nasal S. aureus carriage is a risk factor for S. aureus infections in non-CF patients. Topical treatment strategies successfully eradicate nasal S. aureus carriage, thereby decreasing S. aureus infection. A prospective longitudinal multicenter study was conducted to assess whether nasal carriage represents a risk factor for S. aureus colonization of the oropharynx in young CF patients. Cross-sectional analysis revealed a significantly higher prevalence of S. aureus-positive nasal (28/80 [35%] versus 20/109 [18%]; P < 0.01) and oropharyngeal (35/80 [44%] versus 20/109 [18%]; P < 0.001) cultures in children with CF compared to a control group. The first site of S. aureus detection was the nose in 6 patients and the oropharynx in 14 patients, respectively. Longitudinal analysis demonstrated a significantly higher S. aureus prevalence (61/62 [98%] versus 47/62 [76%]; P < 0.001) and persistence (46/62 [74%] versus 31/62 [50%]; P < 0.01) in the oropharynx than in the nose. In CF patients, the oropharynx, and not the nose, was the predominant site of S. aureus infection and persistence. Hence, it is unlikely that CF patients will benefit from topical treatment strategies to eradicate nasal carriage. 相似文献
76.
Ralf Schiel Thomas Perenthaler Sabine Müller Antje Steveling 《Pr?vention und Gesundheitsf?rderung》2018,13(2):170-178
Background
Medical rehabilitation plays a special role in the treatment of children and adolescents with diabetes mellitus: services which are difficult to implement in an out-patient or an acute in-patient setting can be provided. The study analyzed changes over a period of 12 years.Methods
In a monocentric, retrospective cross-sectional analysis, all (n = 2001) children and adolescents with diabetes (52% girls, age 12.6 ± 4.9 years) who were admitted to a specialist clinic for rehabilitation during the period 01/2004–12/2016 were examined.Results
The duration of medical rehabilitation was 27.3 ± 6.1 days. In all, 1980 of 2001 (98.9%) children and adolescents had type 1 diabetes, while 21 of 2001 (1.1%) had type 2 diabetes. Mean HbA1c was 7.87 ± 1.47%. Overall, 1897 of 2001 (95%) patients had an intensified insulin therapy, of which 633 (32%) used insulin pumps (CSII). They injected 0.86 ± 0.47?I.?U. insulin/kg body weight/day and performed 37.6 ± 11.4 blood glucose self-tests/week. The number of patients who participated in medical rehabilitation decreased: In 2016 it was 68% lower than in 2007, the year of the highest number of patients (p < 0.05). Parameters of metabolic control hardly changed. The proportion of patients with CSII increased (p < 0.05). In particular, young children used CSII more frequently (59% in <4 year olds vs 24% in 16–17 year olds, p < 0.05). Changes also occurred in cultural status: The percentage of patients from German families decreased (p < 0.05); the proportion of patients from mixed-cultural families increased (p < 0.05). The number of patients living together with both parents also decreased (p < 0.05 for the tendency); the number of patients living with single parents increased (p < 0.05 for the tendency). In young children, HbA1c values were the lowest. From the beginning of puberty (about 10 years), HbA1c increased (8.5 ± 1.9% in 16–17 year olds). There were no correlations/associations between metabolic control and the incidences of hypoglycemia/ketoacidoses.Conclusions
There has been a change in medical rehabilitation: The number of patients has decreased, the proportion of patients using CSII has increased, the number of patients living with single parents and the percentage of patients from a culturally mixed families has also increased. Thus, there are new challenges in medical rehabilitation.77.
Beesdo-Baum Katja Knappe Susanne Einsle Franziska Knothe Lisa Wieder Gesine Venz John Rummel-Kluge Christine Heinz Ines Koburger Nicole Schouler-Ocak Meryam Wilbertz Theresia Unger Hans-Peter Walter Ulrich Hein Joachim Hegerl Ulrich Lieb Roselind Pfennig Andrea Schmitt Jochen Hoyer Jürgen Wittchen Hans-Ulrich Bergmann Antje 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2018,61(1):52-64
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Hausärzte sind als Primärversorger für Patienten mit depressiven Störungen entscheidende Weichensteller... 相似文献
78.
Antje Wienecke Klaus Kraywinkel 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2018,61(11):1399-1406
Background and Objectives
Tobacco consumption is the most important cancer risk factor. In Germany, about 15% of all new cancer cases can be attributed to smoking. The aim of this paper is to analyze the incidence and mortality trends in tobacco-associated cancer cases in Germany for the last two decades.Materials and Methods
Age standardized incidence and mortality rates were calculated for tumors of the upper aerodigestive tract and lower urinary tract for the period from 1995 to 2014/2015. In addition, average annual percentage changes were calculated with joinpoint regression analysis. Regarding lung cancer, trends in incidence and mortality rates were also stratified by different age groups and trends in mortality rates were analyzed by birth cohorts.Results
The incidence and mortality rates among men are declining for all tobacco-associated cancers except esophageal cancer. Lung cancer mortality rates showed the greatest decrease with ?1.9% on average per year. The incidence rates among women increased for all tobacco-associated cancers except lower urinary tract cancers. The increase in lung cancer incidence was greatest with 3.3% on average per year. Among men there was a continuous decline over all birth cohorts regarding the chance of dying of lung cancer at a certain age. Among women, the chance of dying of lung cancer increased for all birth cohorts until 1960.Conclusions
The present analyses regarding tobacco-associated cancers in Germany reflect the changes in smoking prevalence with a deferment of multiple decades.79.
Ghaseminejad Farhad Kaplan Lew Pfaller Anna M. Hauck Stefanie M. Grosche Antje 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(2):221-230
Graefe's Archive for Clinical and Experimental Ophthalmology - Diabetic retinopathy (DR) is a sight-threatening complication associated with the highly prevalent diabetes disorder. Both the... 相似文献
80.
Rabea Hein Hendrik J. Sake Claudia Pokoyski Joachim Hundrieser Antje Brinkmann Wiebke Baars Monika Nowak‐Imialek Andrea Lucas‐Hahn Constanca Figueiredo Hans‐Joachim Schuberth Heiner Niemann Bjrn Petersen Reinhard Schwinzer 《American journal of transplantation》2020,20(4):988-998
Porcine xenografts lacking swine leukocyte antigen (SLA) class I are thought to be protected from human T cell responses. We have previously shown that SLA class I deficiency can be achieved in pigs by CRISPR/Cas9‐mediated deletion of β2‐microglobulin (B2M). Here, we characterized another line of genetically modified pigs in which targeting of the B2M locus did not result in complete absence of B2M and SLA class I but rather in significantly reduced expression levels of both molecules. Residual SLA class I was functionally inert, because no proper differentiation of the CD8+ T cell subset was observed in B2Mlow pigs. Cells from B2Mlow pigs were less capable in triggering proliferation of human peripheral blood mononuclear cells in vitro, which was mainly due to the nonresponsiveness of CD8+ T cells. Nevertheless, cytotoxic effector cells developing from unaffected cell populations (eg, CD4+ T cells, natural killer cells) lysed targets from both SLA class I+ wildtype and SLA class Ilow pigs with similar efficiency. These data indicate that the absence of SLA class I is an effective approach to prevent the activation of human CD8+ T cells during the induction phase of an anti‐xenograft response. However, cytotoxic activity of cells during the effector phase cannot be controlled by this approach. 相似文献