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排序方式: 共有849条查询结果,搜索用时 15 毫秒
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Christine E. Ryan Rebecca L. Zon Robert Redd David C. Fisher Roni Shouval Anita Kumar Jennifer L. Crombie Hossein Sadrzadeh Austin I. Kim Lakshmi Nayak Ugonma N. Chukwueke Caron A. Jacobson Matthew J. Frigault M. Lia Palomba Philippe Armand Zachary Epstein-Peterson Reid W. Merryman 《British journal of haematology》2023,203(5):774-780
Data describing outcomes of chimeric antigen receptor (CAR) T-cell therapy in patients with secondary central nervous system (SCNS) involvement of mantle cell lymphoma (MCL) are limited. We identified 10 patients with MCL and SCNS involvement treated with anti-CD19 CAR T-cell therapy at three US academic centres. Frequent objective responses were observed in the CNS (86%) and systemically (90%), and the 1-year progression-free survival was 47%. Seven patients developed immune-effector-cell-associated-neurotoxicity-syndrome (n = 2 Grade 1, n = 5 Grade 3). Our results suggest that anti-CD19 CAR T-cell therapy in this setting is feasible and additional data regarding neurotoxicity in this population may be warranted. 相似文献
845.
Annarita Tagliaferri Angelo Claudio Molinari Flora Peyvandi Antonio Coppola Francesco Demartis Chiara Biasoli Alessandra Borchiellini Dorina Cultrera Raimondo De Cristofaro Filomena Daniele Paola Giordano Emanuela Marchesini Maurizio Margaglione Renato Marino Berardino Pollio Paolo Radossi Cristina Santoro Rita Carlotta Santoro Sergio Siragusa Gianluca Sottilotta Alberto Tosetto Lydia Piscitelli Maria Rosaria Villa Ezio Zanon Adele Finardi Irene Schiavetti Daniella Vaccari Giancarlo Castaman 《Haemophilia》2023,29(1):135-144
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Andrea Matucci Francesca Nencini Giandomenico Maggiore Fabio Chiccoli Matteo Accinno Emanuele Vivarelli Chiara Bruno Luca Giovanni Locatello Annarita Palomba Elena Nucci Valentina Mecheri Margherita Perlato Oliviero Rossi Paola Parronchi Enrico Maggi Oreste Gallo Alessandra Vultaggio 《Clinical and experimental allergy》2023,53(1):78-87
848.
Andrea Lombardi Giulia Renisi Daniele Dondossola Emanuele Palomba Luca Del Prete Giulia Viero Arianna Zefelippo Cecilia Azzarà Angelo Maccaro Carolina Perali Laura Alagna Eloisa Franchi Antonio Muscatello Andrea Gori Giacomo Grasselli Maria Francesca Donato Caterina Matinato Lucio Caccamo Barbara Antonelli Alessandra Bandera 《Transplant infectious disease》2023,25(5):e14130
Background
Perfusion fluid (PRF) is employed in liver transplantation (LTx) to maintain graft viability. Still, it represents a new potential way of infection transmission in LTx recipients (LTRs). Currently, no systematic research has investigated this topic.Methods
Five-year single-center retrospective study conducted on LTRs from January 2017 to December 2021. We analyzed the incidence of positive PRF culture (PRF+) and perfusion fluid-related infections (PRF-RI) and their associated factors. We also assessed 1-year mortality, both overall and infection-related.Results
Overall, 234 LTx were included. PRF+ were found in 31/234 (13.2%) LTx for a total of 37 isolates, with >1 isolate identified in 5 (2.1%) cases. High-risk microorganisms (Enterobacterales 13/37, Enterococcus spp. 4/37, S. aureus 3/37, P. aeruginosa 2/37) were isolated in 25/37 (67.6%) LTRs, the remaining being coagulase-negative staphylococci (12/37, 32.4%). Antimicrobial prophylaxis was administered to all LTRs, always active against the isolate even if suboptimal in 19 cases (61.3%). PRF-RI developed in 4/234 LTx (1.7%), and prophylaxis was considered suboptimal in 2/4 of them. The isolation of >1 microorganism in PRF culture was associated with an increased risk of developing PRF-RI (OR 37.5 [95%CI 2.6–548.4], p = .01). PRF-RI were associated with longer ICU stays (p = .005) and higher 1-year mortality, both overall and related to infections (p = .001).Conclusion
Despite PRF+ being infrequent, only a minority of patients develops PRF-RI. Nonetheless, once occurred, PRF-RI seems to increase morbidity and mortality rates. 相似文献849.
Annarita Barone Martina Billeci Sofia D'Amore Michele De Prisco Giuseppe De Simone Eleonora Ermini Vittorio Freda Federica Iannotta Adalgisa Luciani Luca Pistone Lorenza M. Rifici Viviana M. Saia Giancarlo Spennato Francesco Subosco Licia Vellucci Giordano D'Urso Diana Galletta Michele Fornaro Felice Iasevoli Andrea de Bartolomeis 《Journal of community psychology》2023,51(1):154-167
Few longitudinal studies have so far investigated the impact of sustained COVID-19 among people with pre-existing psychiatric disorders. We conducted a prospective study involving people with serious mental illness (n = 114) and healthy controls (n = 41) to assess changes in the Perceived Stress Scale, Generalized Anxiety Disorder Scale, Patient Health Questionnaire, and Specific Psychotic Experiences Questionnaire scores 18 months after the COVID-19 pandemic outset. Subjects underwent interviews with a mental health professional in April 2020 and at the end of the local third wave (October 2021). A significant increase in perceived stress was found in healthy controls, especially females. Psychiatric patients showed a significant worsening of anxiety symptoms compared to baseline records (t = −2.3, p = 0.036). Patients who rejected vaccination had significantly higher paranoia scores compared to those willing to get vaccinated (U = 649.5, z = −2.02, p = 0.04). These findings indicate that COVID-19's sustained emergency may cause enduring consequences on mental health, soliciting further investigations. 相似文献