全文获取类型
收费全文 | 9069篇 |
免费 | 449篇 |
国内免费 | 34篇 |
专业分类
耳鼻咽喉 | 168篇 |
儿科学 | 367篇 |
妇产科学 | 202篇 |
基础医学 | 825篇 |
口腔科学 | 263篇 |
临床医学 | 623篇 |
内科学 | 1952篇 |
皮肤病学 | 163篇 |
神经病学 | 473篇 |
特种医学 | 277篇 |
外科学 | 1856篇 |
综合类 | 159篇 |
现状与发展 | 1篇 |
一般理论 | 8篇 |
预防医学 | 345篇 |
眼科学 | 198篇 |
药学 | 732篇 |
1篇 | |
中国医学 | 40篇 |
肿瘤学 | 899篇 |
出版年
2023年 | 59篇 |
2022年 | 148篇 |
2021年 | 314篇 |
2020年 | 138篇 |
2019年 | 201篇 |
2018年 | 264篇 |
2017年 | 190篇 |
2016年 | 250篇 |
2015年 | 303篇 |
2014年 | 399篇 |
2013年 | 469篇 |
2012年 | 759篇 |
2011年 | 804篇 |
2010年 | 478篇 |
2009年 | 386篇 |
2008年 | 566篇 |
2007年 | 623篇 |
2006年 | 546篇 |
2005年 | 549篇 |
2004年 | 480篇 |
2003年 | 430篇 |
2002年 | 399篇 |
2001年 | 98篇 |
2000年 | 58篇 |
1999年 | 61篇 |
1998年 | 60篇 |
1997年 | 52篇 |
1996年 | 44篇 |
1995年 | 42篇 |
1994年 | 41篇 |
1993年 | 36篇 |
1992年 | 38篇 |
1991年 | 43篇 |
1990年 | 31篇 |
1989年 | 24篇 |
1988年 | 13篇 |
1987年 | 14篇 |
1986年 | 14篇 |
1985年 | 13篇 |
1984年 | 16篇 |
1983年 | 12篇 |
1982年 | 10篇 |
1981年 | 15篇 |
1980年 | 5篇 |
1979年 | 9篇 |
1977年 | 6篇 |
1976年 | 5篇 |
1970年 | 8篇 |
1969年 | 5篇 |
1968年 | 4篇 |
排序方式: 共有9552条查询结果,搜索用时 0 毫秒
51.
52.
J W Triplett T L Hayden L K McWhorter S R Gautam E E Kim D W Bourne 《Journal of pharmaceutical sciences》1985,74(9):1007-1009
Radioiodinated serum albumin has been used as a blood marker to define and quantitate physiological volumes for 12 organs and tissue types. The concentration of gallium-67 in "blood-free" tissues of rats was also determined at various times after intravenous administration. Tissues were divided into two kinetically distinguishable types based on reported nonuniform distribution of the blood marker and the gallium distribution observed in the present study. Gallium distribution into the liver and spleen was observed to be slow, with a discernable accumulation phase followed by monoexponential elimination. In contrast, gallium accumulation into the stomach, small and large intestines, heart, lung, skin/adipose tissue, and muscle was rapid and elimination was monophasic. 相似文献
53.
Wymbs Frances Doctoroff Greta L. Chacko Anil Sternheim Gillian 《Prevention science》2021,22(7):866-879
Prevention Science - The impact of evidence-based parenting health promotion programs is threatened by limited enrollment and attendance. We used a discrete choice experiment (DCE) to examine how... 相似文献
54.
Julia M. Grottenthaler Annette Konzelmann Anette Stiegler Clemens Hinterleitner Sarah M. Bott Thomas Klag Christoph R. Werner Martina Hinterleitner Alfred Königsrainer Anil Batra Nisar P. Malek Silvio Nadalin Christoph P. Berg 《Transplant international》2021,34(11):2257-2265
Alcohol abuse after liver transplantation can seriously impact graft and patient survival. However, to date, there is no defined standard procedure to identify patients consuming alcohol after liver transplantation. The aim of this study was to analyze the diagnostic value and clinical impact of routinely measured urinary ethyl glucuronide (uEtG) – a metabolite of ethanol – in patients after liver transplantation. Data of 362 consecutive patients after liver transplantation who visited the University Hospital of Tuebingen for outpatient follow-up were analyzed. Forty-eight patients (13%) displayed positive uEtG results. The uEtG positive group contained significantly more patients with pretransplant alcoholic liver disease. However, two thirds of the uEtG positive patients had no history of pretransplant alcoholic liver disease. Several clinical parameters were significantly associated with positive uEtG. In order to enable a more cost-effective application of uEtG in the future, a clinical risk score was developed (specificity 0.95). In conclusion, routine testing for uEtG reveals a considerable percentage of patients practicing alcohol intake after liver transplantation. Application of our proposed risk score could help focusing uEtG testing on patients at risk. 相似文献
55.
Saurabh Kumar Bhushan Shah Ashok Johari Rashid Anjum Devansh Garg Rashmi Salhotra Asha Tyagi Amir Maroof Khan Anil Kumar Jain 《Indian Journal of Orthopaedics》2021,55(2):506
Covid-19 is a respiratory disease caused by coronavirus 2 (SARS-CoV-2) first identified in Wuhan, China (December 2019). The disease rapidly crossed the barrier of countries, continents and spread globally. Non-pharmaceutical measures such as social distancing, face mask, frequent hand washing and use of sanitizer remained the best available option to prevent the spread of disease. OPD, IPD admissions, elective O. Ts were curtailed. Orthopedic care was only limited to emergency and semi-urgent procedures like necrotizing fasciitis, open fracture, and compartment syndrome. These measures were taken to preserve infrastructure and manpower to manage covid-19 pandemic. The children were thought to have a low susceptibility to covid-19 as compared to an adult. Deferring the patient during pandemic has led to high orthopedic disease burden, morbidity and disease-related sequelae, hence elective care must be resumed with modified hospital infrastructure. Resumption of elective/emergent orthopedic care should be slow, phasic and strategic, much similar to unlocking. Cases must be stratified depending on covid status and severity. Dedicated O.Ts with neutral/negative pressure and HEPA filter for covid positive and suspected patients are to be used. All symptomatic and suspected patients should be investigated for covid-19 by RT-PCR, blood counts and CT scan. Regional anaesthesia should be preferred to General anaesthesia. Power drill/saw/burr/pulse lavage should be minimized to avoid aerosol generation. Postoperatively continuous surveillance and monitoring to be done for covid related symptoms. Medical institutes rapidly shifted to the online mode of education. Blended learning (virtual & physical) and imparting skills have to be continued in post covid phase with equitable distribution of teaching hours to students of different years. 相似文献
56.
Rania El Fekih James Hurley Vasisht Tadigotla Areej Alghamdi Anand Srivastava Christine Coticchia John Choi Hazim Allos Karim Yatim Juliano Alhaddad Siawosh Eskandari Philip Chu Albana B. Mihali Isadora T. Lape Mauricio P. Lima Filho Bruno T. Aoyama Anil Chandraker Kassem Safa James F. Markmann Leonardo V. Riella Richard N. Formica Johan Skog Jamil R. Azzi 《Journal of the American Society of Nephrology : JASN》2021,32(4):994
BackgroundDeveloping a noninvasive clinical test to accurately diagnose kidney allograft rejection is critical to improve allograft outcomes. Urinary exosomes, tiny vesicles released into the urine that carry parent cells’ proteins and nucleic acids, reflect the biologic function of the parent cells within the kidney, including immune cells. Their stability in urine makes them a potentially powerful tool for liquid biopsy and a noninvasive diagnostic biomarker for kidney-transplant rejection.MethodsUsing 192 of 220 urine samples with matched biopsy samples from 175 patients who underwent a clinically indicated kidney-transplant biopsy, we isolated urinary exosomal mRNAs and developed rejection signatures on the basis of differential gene expression. We used crossvalidation to assess the performance of the signatures on multiple data subsets.ResultsAn exosomal mRNA signature discriminated between biopsy samples from patients with all-cause rejection and those with no rejection, yielding an area under the curve (AUC) of 0.93 (95% CI, 0.87 to 0.98), which is significantly better than the current standard of care (increase in eGFR AUC of 0.57; 95% CI, 0.49 to 0.65). The exosome-based signature’s negative predictive value was 93.3% and its positive predictive value was 86.2%. Using the same approach, we identified an additional gene signature that discriminated patients with T cell–mediated rejection from those with antibody-mediated rejection (with an AUC of 0.87; 95% CI, 0.76 to 0.97). This signature’s negative predictive value was 90.6% and its positive predictive value was 77.8%.ConclusionsOur findings show that mRNA signatures derived from urinary exosomes represent a powerful and noninvasive tool to screen for kidney allograft rejection. This finding has the potential to assist clinicians in therapeutic decision making. 相似文献
57.
Angela Pecoraro Marina Deuker Giuseppe Rosiello Franziska Stolzenbach Stefano Luzzago Zhe Tian Shahrokh F. Shariat Fred Saad Alberto Briganti Anil Kapoor Cristian Fiori Francesco Porpiglia Pierre I. Karakiewicz 《Urologic oncology》2021,39(4):239.e1-239.e7
BackgroundThe NCCN guidelines recommend active surveillance (AS) as an option for the initial management of cT1a 0-2 cm renal lesions. However, data about comparison between renal cell carcinoma (RCC) 0-2 cm vs. 2.1-4 cm are scarce.MethodsWithin the Surveillance, Epidemiology, and End Results database (2002–2016), 46,630 T1a NanyMany stage patients treated with nephrectomy were identified. Data were tabulated according to histological subtype, tumor grade (low [LG] vs. high [HG]), as well as age category and gender. Additionally, rates of synchronous metastases were quantified.ResultsOverall, 69.3 vs. 74.1% clear cell, 21.4 vs. 17.6% papillary, 6.9 vs. 6.8% chromophobe, 2.0 vs. 1.1% sarcomatoid dedifferentiation, 0.2 vs. 0.2% collecting duct histological subtype were identified for respectively 0-2 cm and 2.1-4 cm RCCs. In both groups, advanced age was associated with higher rate of HG clear cell and HG papillary histological subtype. In 0-2 cm vs. 2.1-4 cm RCCs, 13.8% vs. 20.2% individuals operated on harbored HG tumors and were more prevalent in males. Lower synchronous metastases rates were recorded in 0-2 cm RCC and ranged from 0 in respectively multilocular cystic to 0.9% in HG papillary histological subtype. The highest synchronous metastases rates were recorded in sarcomatoid dedifferentiation histological subtype (13.8% and 9.7%) in both groups.ConclusionsRelative to 2.1-4 cm RCCs, 0-2 cm RCCs harbored lower rates of HG tumors, lower rates of aggressive variant histology and lower rates of synchronous metastases. The indications and demographics of patients selected for AS may be expanded in the future to include younger and healthier patients. 相似文献
58.
Jo-Lynn S. Tan Niranjan Sathianathen Marcus Cumberbatch Prokar Dasgupta Alexandre Mottrie Ronney Abaza Koon Ho Rha Thyavihally B. Yuvaraja Dipen J. Parekh Umberto Capitanio Rajesh Ahlawat Sudhir Rawal Nicolò M. Buffi Ananthakrishnan Sivaraman Kris K. Maes Gagan Gautam Francesco Porpiglia Levent Turkeri Mahendra Bhandari Benjamin Challacombe James Roscoe Porter Craig R. Rogers Daniel A. Moon 《BJU international》2021,128(Z3):30-35
59.
Mounissamy Vassanda Coumar Parihar Raghbendra Singh Dwivedi Anil Kumar Saha Jayanta Kumar Rajendiran Selladurai Lakaria Brij Lal Patra Ashok Kumar 《Bulletin of environmental contamination and toxicology》2021,106(3):536-544
Bulletin of Environmental Contamination and Toxicology - An experiment was conducted to study the effects of co-composted products of municipal solid waste (MSW) and pigeon pea biochar (PPB) on... 相似文献
60.
Gautam K Campbell C Barrington B 《Journal of health and human services administration》1997,20(2):217-229
This study compares the characteristics of rural hospitals with urban safety-net hospitals and with "other urban hospitals" (non-teaching, non-safety-net urban hospitals that provide mainstream care in the United States). The objective is to examine if there are similarities between rural and urban safety-net hospitals, both of which serve underserved populations. The authors also wish to study if there are areas in which rural and urban safety-net hospitals are closer together compared to "other" urban hospitals. Based on the results, some potential areas of cooperation between rural and urban safety-net hospitals are discussed. 相似文献