全文获取类型
收费全文 | 34024篇 |
免费 | 3335篇 |
国内免费 | 41篇 |
专业分类
耳鼻咽喉 | 414篇 |
儿科学 | 1052篇 |
妇产科学 | 954篇 |
基础医学 | 4683篇 |
口腔科学 | 758篇 |
临床医学 | 3586篇 |
内科学 | 7068篇 |
皮肤病学 | 442篇 |
神经病学 | 2719篇 |
特种医学 | 1110篇 |
外国民族医学 | 9篇 |
外科学 | 4371篇 |
综合类 | 751篇 |
一般理论 | 28篇 |
预防医学 | 3933篇 |
眼科学 | 825篇 |
药学 | 2379篇 |
中国医学 | 37篇 |
肿瘤学 | 2281篇 |
出版年
2021年 | 456篇 |
2020年 | 254篇 |
2019年 | 459篇 |
2018年 | 520篇 |
2017年 | 450篇 |
2016年 | 424篇 |
2015年 | 455篇 |
2014年 | 715篇 |
2013年 | 1105篇 |
2012年 | 1557篇 |
2011年 | 1612篇 |
2010年 | 855篇 |
2009年 | 760篇 |
2008年 | 1419篇 |
2007年 | 1561篇 |
2006年 | 1511篇 |
2005年 | 1401篇 |
2004年 | 1284篇 |
2003年 | 1253篇 |
2002年 | 1272篇 |
2001年 | 1130篇 |
2000年 | 1176篇 |
1999年 | 986篇 |
1998年 | 352篇 |
1997年 | 323篇 |
1996年 | 349篇 |
1995年 | 307篇 |
1994年 | 310篇 |
1993年 | 292篇 |
1992年 | 915篇 |
1991年 | 909篇 |
1990年 | 822篇 |
1989年 | 764篇 |
1988年 | 676篇 |
1987年 | 693篇 |
1986年 | 692篇 |
1985年 | 675篇 |
1984年 | 550篇 |
1983年 | 429篇 |
1982年 | 331篇 |
1981年 | 283篇 |
1980年 | 256篇 |
1979年 | 532篇 |
1978年 | 321篇 |
1977年 | 257篇 |
1976年 | 278篇 |
1975年 | 316篇 |
1974年 | 353篇 |
1973年 | 293篇 |
1972年 | 273篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Mariacristina Scoto Thomas Cullup Sebahattin Cirak Shu Yau Adnan Y Manzur Lucy Feng Thomas S Jacques Glenn Anderson Stephen Abbs Caroline Sewry Heinz Jungbluth Francesco Muntoni 《European journal of human genetics : EJHG》2013,21(11):1249-1252
Recessive nebulin (NEB) mutations are a common cause of nemaline myopathy (NM), typically characterized by generalized weakness of early-onset and nemaline rods on muscle biopsy. Exceptional adult cases with additional cores and an isolated distal weakness have been reported. The large NEB gene with 183 exons has been an obstacle for the genetic work-up. Here we report a childhood-onset case with distal weakness and a core-rod myopathy, associated with recessive NEB mutations identified by next generation sequencing (NGS). This 6-year-old boy presented with a history of gross-motor difficulties following a normal early development. He had distal leg weakness with bilateral foot drop, as well as axial muscle weakness, scoliosis and spinal rigidity; additionally he required nocturnal respiratory support. Muscle magnetic resonance (MR) imaging showed distal involvement in the medial and anterior compartment of the lower leg. A muscle biopsy featured both rods and cores. Initial targeted testing identified a heterozygous Nebulin exon 55 deletion. Further analysis using NGS revealed a frameshifting 4 bp duplication, c.24372_24375dup (P.Val8126fs), on the opposite allele. This case illustrates that NEB mutations can cause childhood onset distal NM, with additional cores on muscle biopsy and proves the diagnostic utility of NGS for myopathies, particularly when large genes are implicated. 相似文献
992.
993.
Christianne Velozo Luiz Ricardo Nogueira Luiz Ricardo Nogueira Filho Anderson Capistrano Diana Santana de Albuquerque 《Dental traumatology》2021,37(3):521-530
This case report demonstrates the possibility of functional and aesthetic rehabilitation using an interdisciplinary approach in a child following avulsion of a tooth. Autotransplantation after the development of calcific metamorphosis of the pulp and acute apical periodontitis provided satisfactory repair after root canal treatment. A 7-year-old white boy avulsed the right maxillary central incisor (tooth 11). The extra-alveolar time exceeded 60 minutes, and this triggered external replacement resorption of the avulsed tooth. At 11 years of age, the child underwent tooth autotransplantation. After 4 years of follow-up, intraoral clinical and radiographic examination led to the diagnosis of calcific metamorphosis of the pulp and acute apical periodontitis. The patient had minimally invasive root canal treatment, orthodontic treatment and esthetic rehabilitation with a porcelain crown. Control periapical radiography and tomography of the autotransplanted tooth after 7 years revealed bone repair in the periapical region. This case report indicates that tooth autotransplantation can be used to replace anterior teeth after avulsion followed by replacement resorption. Interdisciplinary management helped to maintain the esthetics and function of the rehabilitated area. 相似文献
994.
995.
T. Kudinha J.R. Johnson S.D. Andrew F. Kong P. Anderson G.L. Gilbert 《Clinical microbiology and infection》2013,19(4):E173-E180
Urinary tract infections (UTI), which are mostly caused by Escherichia coli, are an important public health problem worldwide. Although men experience diverse UTI syndromes, there have been relatively few molecular-epidemiological studies of UTI pathogenesis in men. We studied the distribution of 22 E. coli virulence factor (VF) genes, major phylogenetic groups, sequence type ST131, and UTI-associated O antigens among 101 pyelonephritis, 153 cystitis and 135 fecal healthy control E. coli isolates from men aged 30–70 years in a regional area of NSW, Australia. Overall, the studied traits exhibited a prevalence gradient across these groups, highest in pyelonephritis, intermediate in cystitis, and lowest among fecal isolates. Differences in virulence gene prevalence between cystitis and pyelonephritis isolates were limited to eight genes. The UTI-associated O antigens were also distributed widely, but types O6, O25 and O75 were significantly associated with pyelonephritis. The ST131 clonal group, which accounted for 13% of isolates overall (22% of group B2 isolates), likewise exhibited a significant descending prevalence gradient from pyelonephritis (36%), through cystitis (8%), to fecal (0%) isolates. These findings contribute to better understanding of the pathogenesis of UTIs in men and identify specific VF genes and O types, and a prominent clonal group (ST131), as being important in UTI pathogenesis in this population. 相似文献
996.
Kelli L. Barr Ali M. Messenger Benjamin D. Anderson John A. Friary Gary L. Heil Kristy Reece Gregory C. Gray 《Journal of clinical virology》2013,56(1):57-61
BackgroundA major impediment to performing virological field studies in developing nations is the lack of ultra-low freezers as well as the expense and difficulty of shipping frozen samples. A commercially available product, ViveST?, was developed to preserve nucleic acids at ambient temperature for use in specimen storage and transportation. However, its applications as a viral storage, transport and recovery device have not been evaluated.ObjectiveTo examine the ability of ViveST to preserve live virus following storage at ambient temperature.Study designA panel of six viruses was stored at ambient temperature (~22 °C) in ViveST with fetal bovine serum (FBS), or ViveST with minimal essential media (MEM) and compared with virus stored in universal transport media (M4RT), MEM, and FBS alone. Stored viruses included: human adenovirus (14p), dengue virus 2 (16608), echovirus 3 (Morrisey), human rhinovirus 15 (1734), Coxsackie virus B5 (Faulkner), and herpes simplex virus 1 (HF). After 7 days storage at ambient temperature, virus recovery was measured via titration using viral plaque assays or focus-forming unit assays.ResultsViral titer studies indicate that ViveST with either FBS or M4RT preserved/recovered 5 different viruses for 1 week at ambient temperature. MEM preserved 4 viruses while FBS and ViveST with MEM preserved 3 viruses each. Statistical analyses indicate that M4RT and ViveST with FBS preserved significantly more virus than the other treatments.ConclusionsThese data suggest that ViveST with either FBS or M4RT may be useful in field specimen collection scenarios where ultra-cold storage is not available. 相似文献
997.
998.
Anthony Michael Nasser Bill Vicenzino Alison Grimaldi Jay Anderson Adam Ivan Semciw 《International Journal of Sports Physical Therapy》2021,16(2):288
BackgroundProximal hamstring tendinopathy affects athletic and non-athletic populations and is associated with longstanding buttock pain. The condition is common in track and field, long distance running and field-based sports. Management options need to be evaluated to direct appropriate clinical management.Purpose/HypothesisTo evaluate surgical and non-surgical interventions used in managing proximal hamstring tendinopathy.Study designSystematic reviewMethodsElectronic databases were searched to January 2019. Studies (all designs) investigating interventions for people with proximal hamstring tendinopathy were eligible. Outcomes included symptoms, physical function, quality of life and adverse events. Studies were screened for risk of bias. Reporting quality was assessed using the Cochrane Risk of Bias Tool (Randomized Controlled Trials [RCT]) and the Joanna Briggs Institute Checklist (Case Series). Effect sizes (Standard mean difference or Standard paired difference) of 0.2, 0.5 and 0.8 were considered as small, medium and large respectively. Overall quality of evidence was rated according to GRADE guidelines.ResultsTwelve studies (2 RCTs and 10 case series) were included (n=424; males 229). RCTs examined the following interventions: platelet-rich plasma injection (n=1), autologous whole-blood injection (n=1), shockwave therapy (n=1) and multi-modal intervention (n=1). Case series included evaluation of the following interventions: platelet-rich plasma injection (n=3), surgery (n=4), corticosteroid injection (n=2), multi-modal intervention + platelet-rich plasma injection (n=1). Very low-level evidence found shockwave therapy was more effective than a multi-modal intervention, by a large effect on improving symptoms (-3.22 SMD; 95% CI -4.28, -2.16) and physical function (-2.42 SMD; 95% CI-3.33, -1.50) in the long-term. There was very low-level evidence of no difference between autologous whole-blood injection and platelet-rich plasma injection on physical function (0.17 SMD; 95% CI -0.86, 1.21) to (0.24 SMD; 95% CI -0.76, 1.24) and quality of life (-0.04 SMD; 95%CI -1.05, 0.97) in the medium-term. There was very low-quality evidence that surgery resulted in a large reduction in symptoms (-1.89 SPD; 95% CI -2.36, -1.41) to (-6.02 SPD; 95% CI -8.10, -3.94) and physical function (-4.08 SPD; 95%CI -5.53, -2.63) in the long-term.ConclusionsThere is insufficient evidence to recommend any one intervention over another. A pragmatic approach would be to initially trial approaches proven successful in other tendinopathies.Level of evidenceLevel 2a 相似文献
999.
1000.