Surgical management of trismus due to Oral Submucous Fibrosis — Lysis of fibrotic bands with the KTP-532 Laser

Oral Submucous Fibrosis is an insidious, chronic disease affecting the oral cavity, sometimes the pharynx and rarely the tongue. 15 patients with Oral Submucous Fibrosis presenting with severe trismus were treated with lysis of the fibrotic bands with a KTP-532 Laser and adjunctive treatment with excellent results over a 12 month follow-up period.     

Competitive dissociation of encephalitogenic complexes between antigen presenting cells and myelin basic protein

Splenic T cells from myelin basic protein (MBP)-immunised Lewis rats were activated to transfer experimental autoimmune encephalomyelitis (EAE) by co-culture with MBP-pulsed lymphoid dendritic cells (DC). MBP-pulsed DC could be kept for at least 24 h at 37 degrees C in antigen-free medium without affecting their ability subsequently to activate encephalitogenic T cells. However, MBP-pulsed DC were rendered much less stimulatory after a 6 h, but not 2 h, secondary incubation with ovalbumin. Thus, although encephalitogenic complexes between MBP and DC appear very stable in the absence of competing antigens, in their presence, antigen exchange can take place over a period of a few hours; this has positive implications for therapy of EAE by antigen competition.     

A comparison of presenting characteristics of patients with intracapsular and extracapsular proximal femoral fractures.

The presenting characteristics of 1423 consecutive admissions with proximal femoral fractures were prospectively studied, to determine any differences that may exist between patients, dependent on the radiological site of the fracture. Patients with intracapsular fractures were of a lower average age, more mobile, less likely to use walking aids or live in residential accommodation, they also had a considerably shorter length of hospital stay than for those patients with extracapsular fractures. Comparison against previous series shows that the average age of hip fracture patients and the proportion of trochanteric fractures is increasing.     

TRANSCONJUNCTIVAL OOZING AFTER GLAUCOMA SURGERY

Aim: To study the prevalence of filtration-bleb transconjunctival oozing in the first postoperative year after various glaucoma procedures. Methods: Cross-sectional, single-point examination of all filtration blebs in eyes which had glaucoma surgery in the last year. Eyes were examined 3-12 months after surgery and were grouped into non-penetrating (NPGS) and penetrating (PGS)     

用丝裂霉素C行青光眼加强手术：滤过泡无血管化及经结膜渗漏和滤过泡裂孔的发生

目的：前瞻性研究青光眼术中应用丝裂霉素C（MMC）对于结膜滤过泡高危因素如无血管化、经结膜的渗漏（TCO）和滤过泡裂孔的影响。方法：一位观察者对进行了青光眼手术联合MMC的125例连续患者的125只眼进行为期2年的前瞻性研究，这些患者最初都成功地建立了滤过通道。巩膜瓣切开前将MMC置于该区，多数患者MMC0．2g／L持续2min。青光眼手术包括小梁切除术、深巩膜切除术和联合手术。将干燥的荧光素试纸置于滤过泡的无血管区，以观察房水外流[点渗漏（PL）或未流出（TCO）]。     

Evaluation of xanthotoxol for central nervous system activity.

Xanthotoxol (XT), 8-hydroxypsoralen, exhibited dose-graded sedative activity in dogs, cats, rats, mice and hamsters. At doses of 5-20 mg/kg intraperitoneally (i.p.) in cats and 3-100 mg/kg orally (p.o.) in dogs, XT blocked predatory mouse/rat killing behavior. In mice, XT (10-300 mg/kg i.p.) exhibited a dose-dependent reduction in locomotor activity but was less potent in this regard than reference diazepam (10-100 mg/kg i.p.). XT in mice (0.1-10.0 mg/kg i.p.) and in hamsters (0.1-10.0 mg/kg p.o.) antagonized amphetamine-induced hypermobility but was less potent than diazepam. XT elevated the electrical threshold in foot-shock-induced fighting behavior in rats. XT (0.1-30.0 mg/kg p.o.) potentiated pentobarbital-induced narcosis in hamsters at otherwise subeffective doses of pentobarbital. Conditioned avoidance responses in rats were not significantly altered with 1-3 mg/kg i.p. and 30-100 mg/kg p.o. doses of XT but 300 mg/kg p.o. blocked both conditioned and unconditioned response. Doses of 100-1000 mg/kg i.p. of XT in mice were used to study 48-h acute toxicity of XT and its LD50 was estimated to be 468 mg/kg. Doses of 10, 40 and 80 mg/kg p.o. were used to study the chronic toxicity of XT in rats for 6 months and no side effects or abnormalities in reproductive activity or endocrine integrity were noted. The F1 generation of rats from 6-month XT-treated parents were free of teratogenic effects.     

单纯2型糖尿病患者的风险分层：对冠状动脉钙化成像联合选择性心肌灌注成像的前瞻性评价

目的:确定在单纯2型糖尿病患者中亚临床动脉粥样硬化和心肌缺血的患病率和临床预测因素,并评价其与近期临床预后的关系。方法和结果:以501例无心血管疾病史的无症状2型糖尿病患者(年龄53±8岁,61%为男性)为研究对象,前瞻性检测受试者的已知危险因素和冠状动脉钙化(CAC)评分。所有CAC评分>100Agatston单位(AU)的患者(n=127)以及CAC≤100AU患者中的随机抽样(n=53),接受心肌灌注成像(M PS)检查。46.3%的患者有明显的CAC(>10AU)。在中位期为2.2年的随访(IQR1.9～2.5)中,共发生20例次事件,分别为2例冠状动脉性死亡、9例非致死性心肌梗…