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991.
Rodrigo E. Domínguez Valeria Pfaffen Gustavo A. Argüello Ana G. Iriarte 《Sustainable Chemistry and Pharmacy》2018
An optimized method for the synthesis of thioacetamide (TA) in relation to the consumption of materials and energy, which reduces the production of waste and minimizes costs, is hitherto presented. The most important highlight of this work is the use of an inexpensive and readily accessible reactant for the thionation process (i.e. phosphorus pentasulfide, P4S10), combined with both alumina as solid support and a non-conventional microwave (MW) irradiation technique. In addition to this, Response Surface Methodology (RSM) was used to optimize the entire procedure of the synthesis for simultaneous tripled-maximization of Yield (ε), Mass Intensity (MI) and Mass Productivity (MP). Acetamide (AC)/P4S10 molar ratio, time and temperature of reaction were chosen as independent variables; while ε, MI and MP were chosen as responses. The determination of these green metrics parameters allow to evaluate the sustainability of the reaction and compare with other methodologies. A quadratic regression model was derived with satisfactory prediction. Tripled optimization with desirability function predicts a maximum ε of 100%, maximum MI of 29.00 kg/kg and a maximum MP of 3.45% under the following experimental conditions: AC/P4S10 molar ratio of 2.10, time of irradiation of 14 min and a temperature 140 °C. 相似文献
992.
Ludmylla Cunha Ana M. Rosa da Costa João P. Lourenço Francesca Buttini 《Journal of microencapsulation》2018,35(4):392-405
Pulmonary tuberculosis accounts for 80% of cases and the delivery of antitubercular drugs into the lungs allows targeting the infected organ and, possibly, reducing systemic drug toxicity. This work aimed at using fucoidan as matrix of inhalable microparticles that associate two first-line antitubercular drugs, for an application in pulmonary tuberculosis therapy. Fucoidan is composed of fucose and sulphated sugar residues, moieties described as being recognised by surface receptors of alveolar macrophages, which host mycobacteria. Inhalable fucoidan microparticles loaded with antitubercular drugs were successfully produced with high association efficiencies of either isoniazid (95%) or rifabutin (81%). The microparticles evidenced no cytotoxicity on lung epithelial cells (A549). However, rifabutin-loaded microparticles showed a certain degree of toxicity on macrophage-like cells (THP-1) at the highest tested concentration (1?mg/mL). Furthermore, microparticles showed favourable aerodynamic properties for deep lung delivery (MMAD 2.0–3.8?µm) and, thus, show potential for an application as inhalable tuberculosis therapy. 相似文献
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Mariane C. F. Barbosa Daniela C. Lima Caio L. B. Reis Ana L. M. Reis Darlan Rigo Raquel A. B. Segato Carmen L. M. Storrer Erika C. Küchler Daniela S. B. de Oliveira 《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》2020,30(5):642-649
998.
Luciane R. Costa Cristiane B. Bendo Anelise Daher Ellie Heidari Renata S Rocha Ana Paula de Sousa Costa Moreira Larissa Silva Moura Avijit Banerjee J. Tim Newton Marie T. Hosey 《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》2020,30(5):556-569
999.
Daz-Faes Luca Fernndez-Somoano Ana Magn-Fernndez Antonio Mesa Francisco 《Clinical oral investigations》2020,24(4):1369-1378
Clinical Oral Investigations - To analyse evidence regarding the efficacy of periodontal regenerative procedures in intrabony defects in patients treated for aggressive periodontitis (AgP). A... 相似文献