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991.
Bertoldi EG Severo MD Scheffel RS Foppa M de Azevedo MJ Maia AL 《Echocardiography (Mount Kisco, N.Y.)》2012,29(2):E30-E33
Intracardiac metastases of thyroid carcinoma are a rare event. Their incidence is low in large autopsy series, and antemortem diagnosis is even less common. We present the case of a woman with advanced poorly differentiated thyroid carcinoma who had extensive intracardiac metastases. This case highlights the usefulness of echocardiography and magnetic resonance imaging in the diagnosis and differential diagnosis of cardiac metastases. 相似文献
992.
Carmona-López MI De Miguel M Galera-Ruiz H Ríos-Moreno MJ Fernández A Galera-Davidson H 《Endocrine research》2012,37(4):188-196
Introduction. A study was conducted on histological patterns and biomolecular changes in Goitrogen-induced experimental rat thyroid tumors. The link between the histological types observed and N-ras, B-raf, and PI3KCA gene mutations widely reported in human thyroid cancers was explored. Material and Methods. An analysis was done on paraffin-embedded tumor tissue sections from Wistar rats receiving 1% potassium perchlorate (KClO(4)) added to the ad libitum drinking-water supply over an 18-month period. Three experimental subgroups were formed, each comprising 10 thyroids: subgroup I (control) consisted of thyroids from untreated controls; subgroups II and III (experimental) consisted of thyroids from KClO(4)-treated rats, displaying capsular, vascular, or both invasion but no metastasis (II), or distant metastasis (III). DNA was extracted from paraffin-embedded tissues. To test for the genetic mutations most widely reported in human thyroid cancers, exon 1 of the N-ras gene, exons 9 and 20 of the PI3KCA gene, and exon 15 of the B-raf gene were amplified and sequenced. Results. All tumors were of the follicular type. None of the 20 experimental rat thyroids displayed the expected gene mutations reported in humans. However, 90% of them contained four new B-raf gene mutations and all were silent and did not cause an amino acid substitution in the protein chain. Conclusions. Biomolecular analysis suggested that N-ras, PI3KCA, and B-raf gene mutations may not be involved in thyroid tumor formation using the experimental procedure applied in this study. But the four mutations in B-raf, though without functional repercussions, may be a specific marker for this tumor type. 相似文献
993.
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995.
Ana Isabel Gualberto Buela-Casal Maria Bermúdez Rosario Cabello-Salas 《The Clinical neuropsychologist》2013,27(2):277-283
Several studies have shown that sleep fragmentation not only increases daytime sleepiness, but also deteriorates reaction time. Obstructive sleep apnea syndrome(OSAS)is characterized by interruptions in normal sleep patterns. Nasal Continuous Positive Airway Pressure(nCPAP)is the most frequently used treatment for OSAS. The objective of this investigation was to evaluate changes in daytime sleepiness levels and reaction time in apnea patients after nCPAP treatments of 1 and 3 months. The sample was composed of 51 obstructive sleep apnea patients(47 men and 4 women)with ages ranging between 30 and 65 years of age. Sleep apnea was diagnosed with a cardiorespiratory polygraph of the total hours of sleep. The Epworth Sleepiness Scale was used to assess daytime sleepiness. A BASIC software program was used to measure the simple perceptual reaction times in milliseconds. The results indicated statistically significant decreases in daytime sleepiness levels at 1 month(p?<?.000)and at 3 months(p?<?.000)of treatment. The results also showed statistically significant decreases in reaction times at one month(p?<?.000), as well as at 3 months(p?<?.000)of treatment. Results indicate an improvement in the vigilance levels of obstructive sleep apnea patients after 1 month and 3 months of nCPAP treatment. 相似文献
996.
Ana García-Blanco Pablo González-Valls Carmen Iranzo-Tatay Luis Rojo-Moreno Pilar Sierra Lorenzo Livianos 《International journal of psychiatry in clinical practice》2013,17(4):310-313
AbstractObjective: The determination of soft signs can be a conducive practice to understand the differential etiology between depression and anxiety. This study aims at examining malleolar hypoesthesia role in distinguishing between patients with generalised anxiety disorder (GAD) and major depression disorder (MDD).Methods: This study examines the presence of malleolar hypoesthesia in patients with GAD (n?=?47) compared to patients with MDD (n?=?48) and healthy individuals (controls; n?=?99). The Wartenberg wheel, a medical device for neurological use, was employed to determine the presence of hypoesthesia on both sides of the ankles.Results: The data revealed: i) MDD patients showed higher hypoesthesia than GAD patients (p?=?.008), ii) participants with hypoesthesia had higher anxiety and depression scores than participants without hypoesthesia (all p?<?.001) and iii) logistic regression model indicated that hypoesthesia can be a predictor of MDD relative to GAD diagnosis (Odds Ratio: 17.43 (1.40–217.09; p?=?.026)).Conclusions: Malleolar hypoesthesia was higher in MDD than GAD. The detection of hypoesthesia may help to investigate the differential etiology between MDD and GAD diagnosis. 相似文献
997.
Noelle B. Smith Ashton M. Steele Meara L. Weitzman Ana F. Trueba Alicia E. Meuret 《Archives of Suicide Research》2013,17(1):60-74
Self-directed disgust, a component of self-criticism, may present an important, yet unexplored emotion in the context of nonsuicidal self-injury (NSSI). The aim of this study was to examine the role of self-disgust in NSSI, specifically as a potential mediator in the relations between depression and NSSI as well as sexual abuse and NSSI, and to also better understand characteristics that might differentiate recent and past self-injurers. A total of 549 college students completed measures assessing NSSI, self-disgust, depression, anxiety sensitivity, and physical and sexual abuse. Results indicated self-disgust fully mediated the relation between depressive symptoms and NSSI status and partially mediated the relation between sexual abuse and NSSI status. Additionally, compared to past self-injurers (4.6%; n = 25), recent self-injurers (6.4%; n = 35) endorsed significantly higher self-disgust and depressive symptoms. Self-disgust may be an important component in NSSI and should be addressed in treatment. 相似文献
998.
ngel Gil-Agudo Ana de los Reyes-Guzmán Iris Dimbwadyo-Terrer Benito Peasco-Martín Alberto Bernal-Sahún Patricia López-Monteagudo Antonio del Ama-Espinosa José Luis Pons 《中国神经再生研究》2013,8(19):1773-1782
Upper limb function impairment is one of the most common sequelae of central nervous system in jury, especially in stroke patients and when spinal cord injury produces tetraplegia. Conventional assessment methods cannot provide objective evaluation of patient performance and the effec tiveness of therapies. The most common assessment tools are based on rating scales, which are inefficient when measuring small changes and can yield subjective bias. In this study, we designed an inertial sensorbased monitoring system composed of five sensors to measure and analyze the complex movements of the upper limbs, which are common in activities of daily living. We devel oped a kinematic model with nine degrees of freedom to analyze upper limb and head movements in three dimensions. This system was then validated using a commercial optoelectronic system. These findings suggest that an inertial sensorbased motion tracking system can be used in patients who have upper limb impairment through data integration with a virtual realitybased neurorehabili tation system. 相似文献
999.
Ana Helena Perosa Aripuan? S. A. Watanabe Sandra B. Guatura Ellen R. M. Silva Celso Granato Nancy Bellei 《Clinics (S?o Paulo, Brazil)》2013,68(9):1206-1209
OBJECTIVE:
This study evaluated the diagnostic performance of two methods for the detection of influenza virus in immunocompromised transplant patients.METHODS:
A total of 475 respiratory samples, 236 from patients in a hematopoietic stem cell transplantation program and 239 from kidney transplant patients, were analyzed by a direct fluorescence assay and the Centers for Disease Control real-time polymerase chain reaction protocol for influenza A and B detection.RESULTS:
Influenza detection using either method was 7.6% in the hematopoietic stem cell transplant group and 30.5% in the kidney transplant patient group. Influenza detection by real-time polymerase chain reaction yielded a higher positive rate compared with fluorescence than that reported by other studies, and this difference was more pronounced for influenza A. The fluorescence assay sensitivity, specificity, positive and negative predictive values, and kappa coefficient were 17.6%, 100%, 1, 0.83, and 0.256, respectively, and lower detection rates occurred in the kidney transplant patients.CONCLUSIONS:
The real-time polymerase chain reaction performance and the associated turnaround time for a large number of samples support the choice of this method for use in different routine diagnostic settings and influenza surveillance in high-risk patients. 相似文献1000.
Manoel J. Teixeira Massako Okada Ana Sofia Cueva Moscoso Mariana Yumi Takahashi Puerta Lin T. Yeng Ricardo Galhardoni Sérgio Tengan Daniel Ciampi de Andrade 《Clinics (S?o Paulo, Brazil)》2013,68(7):1057-1060