全文获取类型
收费全文 | 32012篇 |
免费 | 2030篇 |
国内免费 | 151篇 |
专业分类
耳鼻咽喉 | 320篇 |
儿科学 | 782篇 |
妇产科学 | 796篇 |
基础医学 | 4758篇 |
口腔科学 | 1876篇 |
临床医学 | 2713篇 |
内科学 | 7144篇 |
皮肤病学 | 983篇 |
神经病学 | 2790篇 |
特种医学 | 531篇 |
外科学 | 2651篇 |
综合类 | 126篇 |
一般理论 | 21篇 |
预防医学 | 3559篇 |
眼科学 | 533篇 |
药学 | 2548篇 |
中国医学 | 192篇 |
肿瘤学 | 1870篇 |
出版年
2024年 | 30篇 |
2023年 | 353篇 |
2022年 | 534篇 |
2021年 | 1530篇 |
2020年 | 869篇 |
2019年 | 1254篇 |
2018年 | 1522篇 |
2017年 | 1013篇 |
2016年 | 964篇 |
2015年 | 1200篇 |
2014年 | 1583篇 |
2013年 | 1940篇 |
2012年 | 2968篇 |
2011年 | 3132篇 |
2010年 | 1558篇 |
2009年 | 1308篇 |
2008年 | 2159篇 |
2007年 | 2093篇 |
2006年 | 1823篇 |
2005年 | 1587篇 |
2004年 | 1384篇 |
2003年 | 1162篇 |
2002年 | 1019篇 |
2001年 | 117篇 |
2000年 | 78篇 |
1999年 | 111篇 |
1998年 | 139篇 |
1997年 | 129篇 |
1996年 | 83篇 |
1995年 | 65篇 |
1994年 | 68篇 |
1993年 | 51篇 |
1992年 | 52篇 |
1991年 | 40篇 |
1990年 | 36篇 |
1989年 | 25篇 |
1988年 | 25篇 |
1987年 | 22篇 |
1986年 | 27篇 |
1985年 | 19篇 |
1984年 | 13篇 |
1983年 | 16篇 |
1982年 | 19篇 |
1981年 | 10篇 |
1980年 | 14篇 |
1978年 | 6篇 |
1976年 | 6篇 |
1975年 | 7篇 |
1973年 | 5篇 |
1972年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 953 毫秒
991.
López C Baumann T Costa D López-Guerra M Navarro A Gómez C Arias A Muñoz C Rozman M Villamor N Colomer D Montserrat E Campo E Carrió A 《British journal of haematology》2012,156(5):612-618
The analysis of chromosomal abnormalities provides significant prognostic information in patients with chronic lymphocytic leukaemia (CLL), a disease with a highly heterogeneous clinical course. Chromosomal abnormalities commonly found are trisomy 12, del(13)(q14), del(11)(q22-23), del(17)(p13) and del(6)(q21). Translocations are present in some patients and affect regions recurrently involved in CLL. This report describes the clinical and pathological characteristics of four CLL patients showing a new recurrent chromosomal abnormality dic(8;17)(p11;p11), that implied loss of the TP53 gene in all cases. In addition, TP53 gene was mutated in three out of four patients. Mechanically, Low Copy Repeats (LCR) in 17p12 and 8p11 may explain the origin of the translocation by non-allelic homologous recombination (NAHR). Isolated dic(8;17)(p11;p11) in patients with mutated IGHV genes status may not have the same prognostic impact as other mutations or deletions affecting the TP53 gene. Larger series are needed to better evaluate the clinical impact of this chromosomal aberration during the course of the disease. 相似文献
992.
993.
994.
995.
Nemec A Pavlica Z Nemec-Svete A Eržen D Milutinović A Petelin M 《Experimental lung research》2012,38(1):9-18
Adjunctive corticosteroid treatment to reduce excessive local inflammatory response in pneumonia is controversial. To study the effects of an early local adjunct dexamethasone treatment on the course of pneumonia and inflammatory/cytokine response, mice were intratracheally inoculated with live Porphyromonas gingivalis and treated with either clindamycin (C), dexamethasone (D), C+D combination, or were not treated (Pg). Six mice from each group were euthanized at 6, 24, 72, and 168 hours after inoculation. Levels of tumor necrosis factor (TNF)-α, soluble TNF-α receptors (sTNFR1 and sTNFR2), interleukin (IL)-1β, and IL-6 in the serum and lung-homogenate supernatant were determined. Lung samples were histopathologically assessed and all findings compared to those found in 24 sham-inoculated mice (phosphate-buffered saline [PBS]). Severe P. gingivalis-induced bronchopneumonia progressed from 24 hours, peaked at 72 hours, and resolved after 168 hours with changes in local and systemic cytokine levels. Clindamycin-treated mice developed only mild bronchopneumonia that resolved fast (72 hours) with an early (6-24 hours) normalization of local and systemic cytokine levels. Similar course of pneumonia and cytokine level changes were observed in mice treated with C+D, but later. Early (6-24 hours) local elevation of sTNFRs was observed in C and C+D groups of mice, whereas nontreated (Pg) mice had increased systemic sTNFRs. Severe bronchopneumonia with delayed resolution was observed in D-group mice, with an early local and systemic decrease in sTNFR1 and persistent elevation of local TNF-α. Clindamycin or a clindamycin-dexamethasone combination treatment significantly improves the course of P. gingivalis-aspiration pneumonia, but more so if clindamycin alone is used. A favorable course of pneumonia seems to be associated with an early elevation of sTNFRs and normalization of TNF-α. 相似文献
996.
Casas-Fischer R Penedo-Pallares A Palacios-Gutierrez JJ Moreno-Torrico A 《American journal of infection control》2012,40(1):9-10
We illustrate how genotyping of mycobacterial strains contributed to the discovery of an undetected outbreak of tuberculosis in a hospital ward, ruling out misleading assumptions of transmission chains. Genotyping should be taken into account in routine tests for the control of tuberculosis. 相似文献
997.
Fernando Borda José María Martínez-Peñuela Ana Borda Miguel Muñoz-Navas Javier Jiménez Cristina Carretero 《Gastroenterologia y hepatologia》2012
Introduction
Colorectal cancer (CRC) can induce an anti-tumoral immune response mediated by T-lymphocytes, which express CD3.Objectives
To analyze the prognostic value of tissue expression of intraepithelial CD3 (CD3I) both overall and in the early tumoral stages.Methods
We revised 251 patients with resected CRC and favorable clinical course. CD3I expression was analyzed by immunohistochemistry. Multivariate analysis was used to analyze the variables independently associated with survival. We analyzed CD3I(+) expression in relation to survival and tumoral progression, both overall and in patients with pTNM(I-II) stage tumors. The sensitivity, specificity, positive and negative predictive values and diagnostic accuracy of CD3I expression were analyzed.Results
A total of 25.9% of patients with CRC were CD3I(+). After a mean follow-up of 74 months, CD3I(+) expression showed a favorable prognostic value for survival in the multivariate analysis (p = 0.045). Survival curves and absence of tumoral progression were more favorable in CD3I(+) cases, both overall (p = 0.009 and p = 0.004, respectively), and in stages I-II (p = 0.029 and p = 0.015). The specificity and positive predictive value of CD3I(+) were as follows: Survival: overall: specificity =0.89; positive predictive value =0.91. Stage (I-II): specificity =0.94; positive predictive value =0.98. Absence of tumoral progression: overall: specificity = 0.89; positive predictive value =0.88. Stage (I-II): specificity =0.92; positive predictive value =0.96.Conclusions
CD3I expression has an favorable independent prognostic value, with statistically significantly higher percentages of survival and absence of tumoral progression. This more favorable outcome is maintained in the less advanced stages (I-II). CD3I expression shows high specificity and positive predictive value. 相似文献998.
999.
1000.
Pérez Moreiras MI Alvarez Gutierrez AE Couselo Villanueva JM Iglesias Porto E González López R Arija Val F 《Gastroenterologia y hepatologia》2012,35(7):476-479
Meckel's diverticulum (MD) is a persistent embryonic remnant occurring in 2% of the general population. This entity is usually clinically silent and is only discovered when complications occur. Diagnosis is rarely made preoperatively. Surgical resection of symptomatic MD is widely accepted but the most appropriate management of asymptomatic MD remains unclear. We present a case of MD that summarizes some of the complications that may occur. The peculiarity of this case was that the complications were caused by a leiomyoma. The presence of tumoral disease in MD accounts for 3.2% of complications. The most common neoplasm is carcinoid tumor. Few publications have reported benign neoplasms in MD, probably due to their low incidence. 相似文献