全文获取类型
收费全文 | 2014篇 |
免费 | 143篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 81篇 |
妇产科学 | 38篇 |
基础医学 | 266篇 |
口腔科学 | 41篇 |
临床医学 | 204篇 |
内科学 | 499篇 |
皮肤病学 | 108篇 |
神经病学 | 70篇 |
特种医学 | 74篇 |
外科学 | 254篇 |
综合类 | 10篇 |
一般理论 | 1篇 |
预防医学 | 182篇 |
眼科学 | 21篇 |
药学 | 82篇 |
肿瘤学 | 207篇 |
出版年
2023年 | 17篇 |
2022年 | 22篇 |
2021年 | 44篇 |
2020年 | 31篇 |
2019年 | 46篇 |
2018年 | 51篇 |
2017年 | 34篇 |
2016年 | 55篇 |
2015年 | 57篇 |
2014年 | 76篇 |
2013年 | 70篇 |
2012年 | 125篇 |
2011年 | 117篇 |
2010年 | 60篇 |
2009年 | 57篇 |
2008年 | 90篇 |
2007年 | 100篇 |
2006年 | 87篇 |
2005年 | 80篇 |
2004年 | 80篇 |
2003年 | 79篇 |
2002年 | 74篇 |
2001年 | 66篇 |
2000年 | 84篇 |
1999年 | 48篇 |
1998年 | 13篇 |
1997年 | 12篇 |
1996年 | 14篇 |
1995年 | 12篇 |
1994年 | 11篇 |
1993年 | 8篇 |
1992年 | 31篇 |
1991年 | 24篇 |
1990年 | 27篇 |
1989年 | 26篇 |
1988年 | 31篇 |
1987年 | 21篇 |
1986年 | 28篇 |
1985年 | 27篇 |
1984年 | 23篇 |
1983年 | 26篇 |
1982年 | 18篇 |
1981年 | 10篇 |
1980年 | 9篇 |
1979年 | 17篇 |
1978年 | 9篇 |
1972年 | 9篇 |
1971年 | 7篇 |
1967年 | 7篇 |
1933年 | 8篇 |
排序方式: 共有2159条查询结果,搜索用时 31 毫秒
31.
Gardner Cameron L. Pavel-Dinu Mara Dobbs Kerry Bosticardo Marita Reardon Paul K. Lack Justin DeRavin Suk See Le Kent Bello Ezekiel Pala Francesca Delmonte Ottavia M. Malech Harry Montel-Hagen Amelie Crooks Gay Acuto Oreste Porteus Matthew H. Notarangelo Luigi D. 《Journal of clinical immunology》2021,41(5):863-863
Journal of Clinical Immunology - A Correction to this paper has been published: https://doi.org/10.1007/s10875-021-01030-6 相似文献
32.
33.
34.
Arne Böttcher Thomas Mencke Amelie Zitzmann Rainald Knecht Nathan Jowett Gabriele Nöldge-Schomburg Hans Wilhelm Pau Steffen Dommerich 《European archives of oto-rhino-laryngology》2014,271(2):345-352
Endotracheal intubation has been associated with a threefold higher incidence of laryngopharyngeal complaints following anesthesia in comparison to laryngeal mask airway. Such complaints, including hoarseness and sore throat, have been reported in up to 90 % of patients within 24 h of extubation. The purpose of this study was to determine which preoperatively documented clinical and anatomic parameters are predictive of laryngo-pharyngeal trauma resulting from elective endotracheal intubation. Fifty-three patients undergoing ENT procedures requiring general anesthesia with endotracheal intubation were recruited. Pre and postoperative laryngostroboscopic examination was performed and findings correlated to preoperative clinical and anatomic parameters. Readily assessed anatomic parameters including height (>180 cm) and weight (>80 kg) correlated significantly to the Eckerbom grade of intubation-associated acute laryngeal injury (rs = 0.374; p = 0.006 and rs = 0.278; p = 0.044, respectively). The mandibular protrusion test also correlated significantly to the Eckerbom grade (rs = 0.462, p = 0.001) while the upper-lip-bite test showed significant correlation to impaired vocal fold oscillation (rs = 0.288, p = 0.036), with injury prediction sensitivities of 37.5 and 39.4 %, respectively. No parameters correlated to subjective complaints (n = 5, 9.2 %). This study provides suggestions on how to improve the classification of intubation-associated laryngeal injuries as well as providing the basis for larger clinical trials in other surgical subspecialties. 相似文献
35.
36.
37.
38.
Therrien Amelie Silvester Jocelyn A. Leonard Maureen M. Leffler Daniel A. Fasano Alessio Kelly Ciaran P. 《Digestive diseases and sciences》2021,66(6):1989-1997
Digestive Diseases and Sciences - Non-responsive celiac disease (NRCD) has many aetiologies, including gluten exposure. Budesonide may be used for refractory celiac disease (RCD) and celiac crisis.... 相似文献
39.
R P Hambrecht G C Schuler T Muth M F Grunze C T Marburger J Niebauer S M Methfessel W Kübler 《The American journal of cardiology》1992,70(2):141-146
Maximal hemodynamic and ventilatory responses using cycle and treadmill ergometer were compared in 52 asymptomatic patients with angiographically proved coronary artery disease. Moreover, test sensitivity with respect to ST-segment depression and typical angina pectoris were compared between exercise modes used. Exercise tests were performed on different days in randomized order. In 42 patients, exercise-induced myocardial ischemia, expressed as a fraction of left ventricular circumference, was assessed by thallium-201 scintigraphy. The main finding of this study was a significantly higher maximal oxygen uptake (1.87 +/- 0.4 vs 2.2 +/- 0.5 liters/min; p less than 0.001), heart rate (148 +/- 19 vs 158 +/- 18 beats/min; p less than 0.001) and rate-pressure product (28.3 +/- 5 x 10(3) vs 30.7 +/- 5 x 10(3); p less than 0.001) during treadmill walking than during cycling. Therefore, stress-induced myocardial ischemia was significantly more extensive after treadmill walking (31 +/- 37 degrees vs 45 +/- 40 degrees; p less than 0.001). Moreover, there were significantly more patients with signs of myocardial ischemia (ST-segment depression or typical angina pectoris, or both) during treadmill than during cycle ergometry (35 vs 25 patients; p less than 0.05). However, lactate levels measured at peak exercise (4.07 +/- 2.0 vs 4.38 +/- 1.9 mmol/liter) and 3 minutes into the recovery period (5.60 +/- 2.2 vs 5.80 +/- 2.2 mmol/liter) were comparable between both methods, indicating no significant difference in anaerobic energy production. These findings suggest that walking on a treadmill represents an exercise method with a greater ability than cycling to detect coronary artery disease. 相似文献
40.
Targeted Resequencing of 29 Candidate Genes and Mouse Expression Studies Implicate ZIC3 and FOXF1 in Human VATER/VACTERL Association 下载免费PDF全文
Alina C. Hilger Jan Halbritter Tracie Pennimpede Amelie van der Ven Georgia Sarma Daniela A. Braun Jonathan D. Porath Stefan Kohl Daw‐Yang Hwang Gabriel C. Dworschak Bernhard G. Hermann Anna Pavlova Osman El‐Maarri Markus M. Nöthen Michael Ludwig Heiko Reutter Friedhelm Hildebrandt 《Human mutation》2015,36(12):1150-1154
The VATER/VACTERL association describes the combination of congenital anomalies including vertebral defects, anorectal malformations, cardiac defects, tracheoesophageal fistula with or without esophageal atresia, renal malformations, and limb defects. As mutations in ciliary genes were observed in diseases related to VATER/VACTERL, we performed targeted resequencing of 25 ciliary candidate genes as well as disease‐associated genes (FOXF1, HOXD13, PTEN, ZIC3) in 123 patients with VATER/VACTERL or VATER/VACTERL‐like phenotype. We detected no biallelic mutation in any of the 25 ciliary candidate genes; however, identified an identical, probably disease‐causing ZIC3 missense mutation (p.Gly17Cys) in four patients and a FOXF1 de novo mutation (p.Gly220Cys) in a further patient. In situ hybridization analyses in mouse embryos between E9.5 and E14.5 revealed Zic3 expression in limb and prevertebral structures, and Foxf1 expression in esophageal, tracheal, vertebral, anal, and genital tubercle tissues, hence VATER/VACTERL organ systems. These data provide strong evidence that mutations in ZIC3 or FOXF1 contribute to VATER/VACTERL. 相似文献