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981.
Trejtnar F Laznicek M Laznickova A Kopecky M Petrik M Béhé M Schmidt J Maecke H Maina T Nock B 《Anticancer research》2007,27(2):907-912
BACKGROUND: Due to their high CCK-2/gastrin receptor selectivity, high affinity, and rapid background clearance, radiolabeled minigastrins (MG) are emerging as promising new tools in the diagnosis and therapy of CCK-2/gastrin receptor-positive tumors. In this study, the pharmacokinetic profile, particularly the excretion mode, of two 111In-labeled minigastrins was compared in rats. The first tracer, 111In-MG-0 is based on (D)Glu1-MG, while the second, 111In-MG-11, is its des-(Glu)5-derivative, expected to be less retained in renal tissue. MATERIALS AND METHODS: The fate of 111In-MG-0 and 111In-MG-11 in the body of rats was investigated during biodistribution and bioelimination experiments, while the respective elimination parameters were determined in perfused rat liver and kidney models. RESULTS: During biodistribution both compounds were rapidly cleared from the blood and most non-target organs whereas activity levels in the bowel and stomach declined slowly. The overall contribution of hepatobiliary excretion of 111In-MG-0 and 111In-MG-11 was relatively small. In the perfused rat liver their elimination into the bile was negligible. In contrast, renal excretion was the major excretion pathway for both analogs, mainly via glomerular filtration. However, kidney levels were substantially higher and retention was more prolonged in the case of 111In-MG-0 as compared to 111In-MG-11. CONCLUSION: The presence of the (Glu)5-chain in 111Ln-MG-0 appears to be implicated in the prolonged radioactivity retention in the kidney of rats. 相似文献
982.
983.
984.
985.
Ida Alzira Gomes Duarte Karen Levy Korkes Vanessa Alice M. Amorim Clarice Kobata Roberta Buense Rosana Lazzarini 《Anais brasileiros de dermatologia》2013,88(2):306-308
Whether parapsoriasis represents an early stage of T-cell cutaneous lymphoma is stillthe subject of controversy. We evaluated the efficacy of phototherapy in thetreatment of parapsoriasis and its relation with TCCL. Patients diagnosed withparapsoriasis and treated with phototherapy PUVA or UVB-NB were selected. Between 1to 8 years following treatment the evolution of their disease was evaluated. In 62patients the cure rate was 79.3% and 17.2% showed improvement of the lesions. Onlytwo patients developed full blown T-cell cutaneous lymphoma. Phototherapy is anexcellent treatment for parapsoriasis, with high cure rates, regardless of the typeof phototherapy employed. Of the 62 patients under study, parapsoriasis showed nogeneral tendency to progress to T-cell cutaneous lymphoma. 相似文献
986.
Achondroplasia is a common cause of short stature. The condition is often encountered on the Trauma and Orthopaedic FRCS examination. This review covers the aetiology, clinical and radiographic features. Current general and orthopaedic treatments are discussed including potential medical developments with natriuretic peptide. 相似文献
987.
Christina Topham Dylan Haynes Alice Frigerio Christopher Hull 《Pediatric dermatology》2019,36(4):e102-e103
A case of a 15‐year‐old male patient with a 3‐year history of linear, segmental amyopathic dermatomyositis with calcinosis cutis is presented. The calcinosis was recalcitrant to treatment with topical steroids and hydroxychloroquine. Topical 10% sodium thiosulfate use for 8 weeks resulted in improvement. The use of topical sodium thiosulfate for patients in whom surgical extraction is not an option is detailed. 相似文献
988.
989.
Diane Pourchot M.D. Christine Bodemer M.D. Ph.D. Alice Phan M.D. Ph.D. Anne‐Claire Bursztejn M.D. Ph.D. Smaïl Hadj‐Rabia M.D. Ph.D. Franck Boralevi M.D. Ph.D. Juliette Miquel M.D. Thomas Hubiche M.D. Eve Puzenat M.D. Anne‐Laure Souillet M.D. Ingrid Kupfer M.D. Maryam Piram M.D. Alain Beauchet M.D. Emmanuel Mahé M.D. Groupe de Recherche de la Société Française de Dermatologie Pédiatrique 《Pediatric dermatology》2017,34(1):58-63