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91.
Alessandra Andrisani Gabriella Donà Chiara Sabbadin Stefano Dall'Acqua Elena Tibaldi Antonella Roveri 《Gynecological endocrinology》2017,33(12):928-932
Endometriosis, an estrogen-dependent chronic gynecological disease in women of reproductive age, is characterized by a systemic inflammation status involving also red blood cells (RBCs). In this study, we evaluated how the protein oxidative status could be involved in the worsening of RBC conditions due to dapsone intake in endometriotic women in potential treatment for skin or infection diseases. Blood samples from two groups of volunteers, control group (CG) and endometriosis patient group (PG), were analyzed for their content of band 3 tyrosine phosphorylation (Tyr-P) and high molecular weight aggregate (HMWA) in membranes, and glutathione (GSH) content and carbonic anhydrase (CA) activity in cytosol. In endometriotic patients, RBC showed the highest level of oxidative-related alterations both in membrane and cytosol. More interestingly, the addition of dapsone hydroxylamine (DDS-NHOH) could induce further increase of both membranes and cytosol markers, with an enhancement of CA activity reaching about 66% of the total cell enzyme amount. In conclusion, in PG the systemic inflammatory status leads to the inability of counteracting adjunctive oxidative stress, with a potential involvement of CA-related pathologies, such as glaucoma. Hence, the importance of the evaluation of therapeutic approaches worsening oxidative imbalance present in PG RBC is underlined. 相似文献
92.
Daiane Cristina Sass Alessandra Vincenzi Jager Fernando Gustavo Tonin Roice Eliana Rosim Mauricio Gomes Constantino 《Toxin reviews》2015,34(1):53-59
This work reports the chemical synthesis of aflatoxin B1 (AFB1)-lysine based on procedures available in the literature, but using lysine without a protection group in the α-amine group. AFB1-exo-8,9-epoxide was obtained by epoxidation of AFB1 with chloroperoxybenzoic acid in dichloromethane and phosphate buffer. Purification and identification of the AFB1-lysine were conducted by liquid chromatography (LC), and its structure was confirmed by LC with mass spectrometer and diode-array detection. The preparation of AFB1-lysine using lysine without a protection group in the α-amine group was completed in 24?h, being a practical modification of available methods that can be reproduced in analytical laboratories. 相似文献
93.
Jennifer L. Hunt Leon Barnes James S. Lewis Jr Magdy E. Mahfouz Pieter J. Slootweg Lester D. R. Thompson Antonio Cardesa Kenneth O. Devaney Douglas R. Gnepp William H. Westra Juan P. Rodrigo Julia A. Woolgar Alessandra Rinaldo Asterios Triantafyllou Robert P. Takes Alfio Ferlito 《European archives of oto-rhino-laryngology》2014,271(2):211-223
Head and neck squamous cell carcinoma (HNSCC) is a common malignancy that continues to be difficult to treat and cure. In many organ systems and tumor types, there have been significant advances in the understanding of the molecular basis for tumorigenesis, disease progression and genetic implications for therapeutics. Although tumorigenesis pathways and the molecular etiologies of HNSCC have been extensively studied, there are still very few diagnostic clinical applications used in practice today. This review discusses current clinically applicable molecular markers, including viral detection of Epstein–Barr virus and human papillomavirus, and molecular targets that are used in diagnosis and management of HNSCC. The common oncogenes EGFR, RAS, CCND1, BRAF, and PIK3CA and tumor suppressor genes p53, CDKN2A and NOTCH are discussed for their associations with HNSCC. Discussion of markers with potential future applications is also included, with a focus on molecular alterations associated with targeted therapy resistance. 相似文献
94.
Andrés Coca-Pelaz Juan P. Rodrigo Daniela Paccagnella Robert P. Takes Alessandra Rinaldo Carl E. Silver Julia A. Woolgar Michael L. Hinni Alfio Ferlito 《European archives of oto-rhino-laryngology》2013,270(2):417-423
Gastroesophageal reflux disease can present with a wide variety of extraesophageal symptoms. In particular, the type of disease characterized predominately by laryngopharyngeal reflux may be difficult to diagnose because of the absence of regurgitation or heartburn. The available battery of diagnostic tools is often insufficient to confirm a diagnosis of reflux, so the diagnosis is often made by elimination. In many cases, treatment with proton pump inhibitors will relieve symptoms and respiratory complications, despite the persistence of non-acidic reflux. Such treatment is often employed to “confirm” the diagnosis, as measured by patient response. Many diseases have been related to this condition in the literature. The authors review knowledge about these manifestations and their relationship with refluxed gastric content. Physiopathology, symptoms and treatment are reviewed in order to clarify our understanding of laryngopharyngeal reflux diseases and related manifestations. 相似文献
95.
With the exception of distant metastasis, the presence of cervical lymph node metastasis is the single most adverse independent prognostic factor in head and neck squamous cell carcinoma. Surgical removal of metastatic cervical lymph nodes had been attempted during the late nineteenth century, with varying techniques and poor results. A systematic approach to en bloc removal of cervical lymph node disease, described in detail by Jawdyński at the end of the nineteenth century and popularized and illustrated by Crile in the early twentieth century, provided consistent and more effective treatment and forms the basis of our current techniques. The concepts of radical neck dissection, employed extensively by Martin, were followed with almost religious consistency by most head and neck surgeons until the late twentieth century, when the principles of 'functional' neck dissection, developed by Suárez and popularized by Bocca, Gavilán, Ballantyne, Byers and others, led to the acceptance of modified radical neck dissection as treatment for lymph node disease in various stages. More recently, selective neck dissection, involving removal of nodes confined to the levels at greatest risk of metastasis from primary tumours at various sites, has become accepted practice for elective and, in some instances, therapeutic treatment of the neck. In the future, sentinel lymph node biopsy and the use of molecular pathological analyses may be employed to predict the presence of occult cervical disease, thus directing therapy to patients at greatest risk and sparing those without regional metastasis. 相似文献
96.
Alfio Ferlito Alessandra Rinaldo Justin A. Bishop Jennifer L. Hunt Vincent Vander Poorten Michelle D. Williams Asterios Triantafyllou Kenneth O. Devaney Douglas R. Gnepp Kimihide Kusafuka Gyorgy B. Halmos William H. Westra Robert P. Takes Lester D. R. Thompson 《European archives of oto-rhino-laryngology》2016,273(3):533-536
Paraneoplastic syndromes are associated with a variety of malignant neoplasms and are systemic and non-metastatic manifestations that develop in a minority of cancer patients. This review examines all published cases of paraneoplastic syndromes associated with neuroendocrine carcinomas of the larynx. There are a total of ten patients reported with paraneoplastic syndromes associated with laryngeal neuroendocrine carcinomas in the literature. Of these, nine died and the tenth is alive with liver metastases. There were five cases of small-cell neuroendocrine carcinoma, four cases of moderately differentiated neuroendocrine carcinoma, and one case of well-differentiated neuroendocrine carcinoma associated with paraneoplastic syndromes. As these syndromes have significant clinical relevance, physicians should be aware of the possible presence of paraneoplastic syndromes in the diagnostic process of patients with neuroendocrine carcinoma of the larynx. 相似文献
97.
98.
Naomi Vidal Ferreira Natalia Gomes Gonçalves Claudia Szlejf Alessandra C. Goulart Itamar de Souza Santos Bruce B. Duncan Maria Inês Schmidt Sandhi Maria Barreto Paulo Caramelli Natan Feter Raphael Machado Castilhos Luciano F. Drager Paulo Lotufo Isabela Benseñor Claudia Kimie Suemoto 《European journal of neurology》2024,31(2):e16139
99.
Ludovica Natali MSc Valentina Meregalli MSc Katie Rowlands BSc Jerome Di Pietro BA Janet Treasure MD Enrico Collantoni MD Paolo Meneguzzo MD Elena Tenconi PhD Angela Favaro MD Francesca Fontana MD Enrico Ceccato DClinPsych Alessandra Sala MD Lucia Valmaggia PhD Valentina Cardi PhD 《The International journal of eating disorders》2024,57(3):703-715
100.
Philippe Voruz Alexandre Cionca Isabele Jacot de Alcntara Anthony NuberChampier Gilles Allali Lamyae Benzakour Patrice H. Lalive Karl O. Lvblad Olivia Braillard Mayssam Nehme Matteo Coen Jacques Serratrice JeanLuc Reny Jrme Pugin Idris Guessous Radek Ptak Basile N. Landis Dan Adler Alessandra Griffa Dimitri Van De Ville Frdric Assal Julie A. Pron 《Human brain mapping》2023,44(4):1629
Neuropsychological deficits and brain damage following SARS‐CoV‐2 infection are not well understood. Then, 116 patients, with either severe, moderate, or mild disease in the acute phase underwent neuropsychological and olfactory tests, as well as completed psychiatric and respiratory questionnaires at 223 ± 42 days postinfection. Additionally, a subgroup of 50 patients underwent functional magnetic resonance imaging. Patients in the severe group displayed poorer verbal episodic memory performances, and moderate patients had reduced mental flexibility. Neuroimaging revealed patterns of hypofunctional and hyperfunctional connectivities in severe patients, while only hyperconnectivity patterns were observed for moderate. The default mode, somatosensory, dorsal attention, subcortical, and cerebellar networks were implicated. Partial least squares correlations analysis confirmed specific association between memory, executive functions performances and brain functional connectivity. The severity of the infection in the acute phase is a predictor of neuropsychological performance 6–9 months following SARS‐CoV‐2 infection. SARS‐CoV‐2 infection causes long‐term memory and executive dysfunctions, related to large‐scale functional brain connectivity alterations. 相似文献