Synthesis and antiinflammatory activity of N-[1-(5-R-Oxy-2-methylbenzofuran-3-yl)ethyl]-N-hydroxyureas

Two benzofuran derivatives — analogs of 5-lipoxygenase antagonist zileuton — have been synthesized and tested. It is established that both compounds possess antiinflammatory activity. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 12, pp. 17–20, December, 2005.     

Changes in the glucagon and growth hormone levels in the blood plasma of healthy persons and of patients with disordered glucose tolerance after insulin administration

In 15 patients with the normal body mass and disturbed glucose tolerance a glycemia level was higher and insulin levels lower than in 10 healthy persons in the first 20 min after i. v. insulin injection (1.2 units per 1 m2 of the body surface). It was suggestive of resistance to insulin in such patients. The level of glucagon in the blood plasma after insulin injection rose in the patients as well as in healthy persons indicating an unchanged response of pancreatic alpha-cells to insulin in this type of diabetes mellitus. A growth hormone level in the blood after insulin injection bid not significantly change in both groups. Glucose homeostasis after insulin injection was regulated not by the growth hormone but mainly by glucagon.