Clinical value of determining the levels of lupus anticoagulant and anti-cardiolipin antibodies

The authors present some literature and their own data on the antiphospholipid syndrome (venous and arterial thromboses; obstetric pathology: spontaneous abortions and intrauterine death of a fetus; CNS involvement: from headaches and disorientation to psychic disorders and cerebral infarctions; thrombocytopenia, early aseptic osteonecrosis and pulmonary hypertension). Altogether 58 patients with lupus erythematosus and 20 patients with a complicated obstetric history were examined. Lupoid anticoagulant and antibodies to cardiolipin were revealed in 27 patients. The determination of antiphospholipid antibodies was shown to be of practical value from the view-point of the knowledge of humoral immunity disorders in systemic lupus erythematosus, more detailed clinico-laboratory characterization of patients, the diagnosis and prediction of disorders of the blood coagulation system, and the development of obstetric pathology.     

Peroneal tendon injuries: CT analysis

Computed tomographic (CT) evaluation of the peroneal tendons was obtained in 25 normal ankles and 30 abnormal ankles studied for trauma. The tendons and associated soft-tissue and bony structures, such as the calcaneofibular ligament, superior and inferior peroneal retinacula, fibular groove, and peroneal tubercle, which have heretofore evaded documentation on routine radiographs, are illustrated and discussed. Special attention is given to normal variations such as convex fibular tip and enlarged peroneal tubercle, which predispose the peroneal tendons to abnormal mechanical stresses. Examples of CT-established peroneal tendon abnormalities in the 30 cases examined are also demonstrated. These abnormalities include subluxation, dislocation, entrapment, and tenosynovitis of the peroneal tendons. The authors believe CT has proved to be an extremely useful and relatively noninvasive imaging tool for the evaluation of peroneal tendon injuries.     

远程二维核磁共振和NOE差谱法研究新生物碱马尾杉碱N的结构

自华南马尾杉[Phlegariurus fordii(Baker)Ching]中分得新生物碱—马尾杉碱N(Ⅰ)。它含有七个季碳。本工作采用远程¹³C—¹HCOSY和远程增强型¹H—¹HCOSY新技术与NOE差谱相配合的方法成功地连接被季碳和杂原子分隔开的自旋系统,推定了其结构。     

茶中儿茶素类和生物碱成分的HPLC分析

建立了以恒组成溶液为流动相的HPLC同时分析茶中5种儿茶素类(C,ECG,EC,EGC,EGCG)和3种生物碱(caf,Tp,Tb)的定量方法,色谱条件为:ODS(10μm)柱,以0.04mol·L^-1柠檬酸水溶液-N,N-二甲基甲酰胺-四氢呋喃(90:16:4)为流动相,UV检测器(278nm),并以二氯磺胺为内标。结果表明:8种成分分离良好,EGCG(7,2%～9.4%)和caf(4.4%～4.7%)分别为儿茶素类和生物碱中含量最高的成分。同时探讨了这些成分的提取方法和分离测定条件。     

The role of anti-phospholipid antibodies in the development of thrombotic complications and in obstetrical pathology

Examination of 115 women for detection of phospholipid antibodies (PLA), lupus anticoagulant and cardiolipin antibodies has demonstrated that in the absence of PLA all pregnancies terminated in the birth of full-term healthy children, while in their presence there were repeated abortions and (or) intrauterine death of a fetus. Obstetrical pathology in women in the presence of PLA was attended by venous and arterial thrombosis, thrombocytopenia, cerebral vasculitis and vascular affections, which is typical of the picture of the antiphospholipid syndrome. A new approach has been suggested to the treatment of such patients with reduction of the activity of lupus anticoagulant and cardiolipin antibodies owing to which pregnancy can be terminated in the birth of viable children.