全文获取类型
收费全文 | 550篇 |
免费 | 28篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 36篇 |
妇产科学 | 15篇 |
基础医学 | 73篇 |
口腔科学 | 10篇 |
临床医学 | 55篇 |
内科学 | 128篇 |
皮肤病学 | 22篇 |
神经病学 | 10篇 |
特种医学 | 48篇 |
外科学 | 42篇 |
综合类 | 35篇 |
预防医学 | 20篇 |
眼科学 | 1篇 |
药学 | 29篇 |
肿瘤学 | 66篇 |
出版年
2022年 | 1篇 |
2021年 | 5篇 |
2020年 | 2篇 |
2019年 | 9篇 |
2018年 | 10篇 |
2017年 | 10篇 |
2016年 | 9篇 |
2015年 | 9篇 |
2014年 | 12篇 |
2013年 | 21篇 |
2012年 | 15篇 |
2011年 | 16篇 |
2010年 | 23篇 |
2009年 | 37篇 |
2008年 | 30篇 |
2007年 | 22篇 |
2006年 | 17篇 |
2005年 | 22篇 |
2004年 | 13篇 |
2003年 | 13篇 |
2002年 | 13篇 |
2001年 | 19篇 |
2000年 | 18篇 |
1999年 | 21篇 |
1998年 | 37篇 |
1997年 | 28篇 |
1996年 | 15篇 |
1995年 | 14篇 |
1994年 | 15篇 |
1993年 | 13篇 |
1992年 | 5篇 |
1991年 | 10篇 |
1990年 | 7篇 |
1989年 | 12篇 |
1988年 | 8篇 |
1987年 | 6篇 |
1986年 | 6篇 |
1985年 | 12篇 |
1984年 | 3篇 |
1983年 | 6篇 |
1982年 | 4篇 |
1981年 | 7篇 |
1980年 | 5篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1971年 | 1篇 |
1955年 | 1篇 |
排序方式: 共有593条查询结果,搜索用时 568 毫秒
41.
A controlled trial comparing sodium cromoglycate 2% nasal solution against placebo has demonstrated that in patients with severe perennial rhinitis sodium cromoglycate is clinically effective and also that gross histological changes in the nasal mucosa are reversed following treatment for eight weeks with this therapy. 相似文献
42.
43.
44.
45.
Muñoz I Gutiérrez A Gimeno C Farga A Alberola J Solano C Prósper F García-Conde J Navarro D 《Journal of medical virology》2001,65(1):77-84
The kinetics of the gB-specific and neutralizing antibody responses to human cytomegalovirus (HCMV) were analyzed in 26 allogeneic stem-cell transplant recipients who either did (n = 20) or did not (n = 6) develop asymptomatic HCMV active infection during the study period. Antibody response profiles varied widely among individuals in both groups, irrespective of whether HCMV active infection did or did not occur. Development of HCMV active infection was not preceded by a decline in functional serum antibody levels. Neither the absence nor the presence of HCMV active infection correlated with either high or low serum levels of gB-specific and neutralizing antibodies, respectively. In most patients, episodes of HCMV replication were not followed by a marked increment in functional serum antibody titers. Therefore, resolution of an ongoing HCMV active infection was not associated with a vigorous antibody response to viral replication. In addition, this study supports previous data indicating that passive transfer of human immunoglobulins may result in an increment in gB-specific and neutralizing serum antibody levels, the magnitude of which varies among recipients; however, both patients with and without measurable increments in serum antibody levels developed HCMV active infections with comparable frequency. 相似文献
46.
Galán Alvarez P Ibáñez García J Funes Vera C López García-Carreño MD Alix Trueba A Pérez Guillermo M Alberola C 《Anales de medicina interna (Madrid, Spain : 1984)》1999,16(9):466-468
Systemic mast cell disease (SMCD) is an idiopathic disorder in which mast cells proliferate and accumulate in various organs including the skin, bone marrow, liver, spleen and lymph nodes. SMCD is regarded as a myeloproliferative disorder for any authors. Associated hematologic disorders can be found in up to one third of patients with SMCD. It may be due to the apparent close relationship between the mast cell and the myeloid cell. 相似文献
47.
The relative bioavailability of metoprolol following oral and rectal administration to volunteers and patients 总被引:1,自引:0,他引:1
F.M. de Stoppelaar L.M.L. Stolk A.J. Beysens J.L.M. Stappers AP.M. Gorgels 《Pharmacy World & Science》1999,21(5):233-238
The pharmacokinetics, efficacy and safety of metoprolol tartrate 25 mg fatty suppositories were studied in 5 healthy volunteers and in 8 patients suffering from instable angina pectoris. Metoprolol 25 mg capsules were used as a control oral dosage form. Metoprolol showed a considerable rectal bioavailability (AUC, C max) and was absorbed quickly from the rectum (T max). In both groups rectal bioavailability was comparable. However, oral bioavailability was much lower in the volunteer group than in the patient group. Furthermore, ratios of metoprolol/aOHmetoprolol concentrations in plasma and urine gave an indication for a partial avoidance of the first pass effect after rectal administration. Further research is necessary to define an exact rectal dosage of metoprolol. In all patients, a substantial drop in heart rate, systolic and diastolic blood pressure was seen after administration of the first suppository. Metoprolol suppositories appear to be an effective, safe and suitable alternative for patients who are in need for beta blocking medication and who are unable to take oral medication for a certain amount of time. 相似文献
48.
Scintiscans of liver and spleen using technetium 99m sulphur colloid in 15 infants with extrahepatic biliary atresia and 11 infants with severe obstructive jaundice (7 with genetic deficiency of alpha 1-antitrypsin) showed similar hepatic size, pattern of isotope uptake, and splenic abnormality with no distinguishing features. In 37 older children with a variety of liver disorders, the scan was invaluable in showing filling defects in five instances. Selenomethionine was taken up not only by the two filling defects due to hepatoblastoma but also in a haemangioendothelioma. In the remaining patiens liver scanning confirmed hepatic abnormality and the necessity for more specific invasive diagnostic investigations. 相似文献
49.
Joan Manel Gasent Blesa Emilio Esteban González Vicente Alberola Candel 《Clinical & translational oncology》2008,10(5):274-280
Lung cancer is a major health problem due to its incidence and mortality. The risk factors, the existence of a preclinical phase, and the relationship between stage at diagnosis and survival are known. A number of strategies that aim to diagnose lung cancer in its earliest stages, based principally on imaging studies, are therefore being tested. Several drugs aimed at reducing the probability of developing lung cancer in the at-risk population are also under study. At the present time, the results obtained have not been encouraging and we do not have a clear strategy either for early diagnosis or for the use of chemopreventive agents. 相似文献
50.