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Ghaemmaghami F Fatemeh G Behroozi S Shohreh B Mousavi A Azamolsadat M Ashrafgangooei T Tahereh A Gilani MM Mitra MG Behtash N Nadereh B Ghanbari Z Zinat G 《Archives of gynecology and obstetrics》2008,278(4):315-318
Background and goals This study is designed to survey gestational trophoblastic neoplasia with vaginal metastases (GTN + VM) manifestations, prognosis
and chemotherapy response in order to consider appropriate chemotherapy regimen for these patients. There have been just a
few studies about treatment of GTN + VM.
Materials and methods Patients with Stage III GTN with or without vaginal metastases who had referred to Vali-e-Asr Hospital during 1996–2006 have
been selected to take part in this study and the size of metastases was measured. Then response and resistance to single and
combination chemotherapy regimens have been compared in these two groups. The data were processed using SPSS system (release
10). Statistical analysis was done with X2 to determine factors associated with complete clinical response. The level of significance was assigned at P < .05.
Results Forty-eight patients with stage III (with pulmonary metastases) GTN patients have been selected, 13 with vaginal metastases
and 35 without vaginal metastases. Incidence of vaginal metastases in stage III was 26%. Metastases were mainly in distal
part of vagina and suburethra. Chief complaint was severe hemorrhage in 25% of patients and was controlled by vaginal packing
with just one exception. Group of vaginal metastases showed 66.6% resistance to first-line chemotherapy, compared to 28.6%
in patients with no vaginal metastases (P-value = 0.010). Median of chemotherapy courses in low-risk vaginal metastatic patients was 5 (mean = 5.2), compared to three
courses in the group without vaginal metastases. Resistance to single chemotherapy was significantly higher in GTN + VM versus
GTN without VM patients and resistance was higher especially in patients with metastases with more than 3 cm (in diameter).
Conclusions Vaginal metastasis with more than 3 cm in diameter is an important prognostic factor in GTN patients. There have higher risks
for severe hemorrhage and resistance to single agent chemotherapy, so in these patients combination chemotherapy, with no
regard to staging and scoring, would be a better choice.
An erratum to this article can be found at 相似文献
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AIM: As ionized magnesium is the active form of magnesium and exerts a therapeutic effect, the present study was performed to determine the levels and correlations between ionized and total magnesium under baseline and therapeutic conditions in patients with severe preeclampsia and eclampsia receiving magnesium sulfate. METHODS: Fifty singleton patients with severe preeclampsia received a loading dose of 4 g of magnesium sulfate, followed by 2 g per hour as maintenance dose until 24 h after delivery, or 24 h after the last seizure in case of postpartum convulsions. Serial blood samples were taken before magnesium sulfate infusion, 30 min and 240 min after the initiation of the infusion and 4 h after the discontinuation of the drug. Data were analyzed by repeated measure ANOVA and paired t-test. RESULTS: Baseline levels of total and ionized magnesium were 2.4+/-0.6 mEq/L and 1.3+/-0.5 mEq/L (mean+/-SD), respectively. Putative level of 4 mEq/L of total magnesium was not obtained in up to 42% of patients during the treatment. There was not any significant correlation between the two forms of magnesium under baseline and therapeutic conditions. CONCLUSION: Despite the effectiveness of the standard regimen of magnesium sulfate in the treatment and prevention of eclamptic seizures, it can not provide the proposed therapeutic level of magnesium in all patients. With respect to the lack of correlation between ionized and total magnesium, further studies are necessary to investigate the superiority of measurement of ionized, rather than total magnesium, for titration of therapeutic magnesium sulfate infusion. 相似文献
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Fatemeh Karimi Esmaeil Biazar Saeed Heidari-Keshel Bahareh Pourjabbar Mohammad Reza Khataminezhad Shervin Shirinbakhsh S. Yasaman Zolfaghari-Moghaddam 《RSC advances》2022,12(21):13472
Platelet-rich fibrin (PRF) as a rich source of effective growth factors has been used as a scaffold in tissue regeneration. It is known that PRF exhibits rapid degradability against enzymes, which should be decreased using crosslinking agents to reduce the release rate of growth factors and increase the effectiveness of tissue regeneration. In this study, a carbodiimide crosslinker with different concentrations (0.01%, 0.05%, 1%, and 2%) was used to modify and improve the properties of PRF gel. The crosslinked gels were evaluated with analyses such as SEM, swelling, degradability, mechanical strength, release test, cytotoxicity, and cell adhesion. The results showed that with increasing crosslinker concentration, the morphology of the fiber structure changes drastically, the swelling rate decreases from 300% (control) to 160% for the crosslinked gel, the degradation time for the control sample increases from 8 days to more than two weeks for the crosslinked gel, and the Young''s modulus increases from 0.15 MPa (control) to 0.61 MPa for the crosslinked samples. Growth factors also showed lower release with increasing crosslinking ratio. Cytotoxicity assays demonstrated that by increasing the crosslinker concentration to 1% w/v, no cytotoxicity was observed. Cellular studies with DAPI staining showed that the cells penetrated well into the gels and were well distributed, especially in gels with lower crosslinker concentrations. In addition, the modified PRF gel can be used as a scaffold for tissue regeneration.1-Ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride (EDC) as a crosslinker can improve the physical and mechanical properties of PRF gel by forming covalent bonds. 相似文献
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Fatemeh Mohaghegh Parvaneh Hatami Arezoo Refaghat Mohammadjavad Mehdizadeh Zeinab Aryanian Nessa Aghazadeh Mohandesi Zeinab Mohseni Afshar 《Clinical Case Reports》2022,10(6)
Development of pemphigus foliaceus (PF) following SARS‐CoV‐2 infection has only been reported in one patient who had received Bamlanivimab and thus might be considered as a drug‐induced case of PF. Here, we reported the first case of PF arising solely after COVID infection without taking any culprit drug. 相似文献
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Seyedeh Fatemeh Musavi Ezmareh Kamran Mehrabani Hadi Raeisi Shahraki 《The Turkish journal of gastroenterology》2022,33(6):532
Background: There is little information about comparison of the mortality patterns in different regions. The current study aimed to assess the trend changes of liver cancer mortality in 6 WHO regions.Methods:The mortality rates of liver cancer in the 6 WHO regions during 1990 to 2017 were extracted from the Global Burden of Disease database. Growth mixture model was used to identify the latent patterns using a set of tools to handle both the within and between trajectory variations. All the modeling procedures were implemented in Mplus 7.4 software.Results:The mortality rate in Africa showed a slow decreasing trend throughout the observation period, but a slow increase was observed in the Eastern Mediterranean region, European region, region of the Americas, and South-East Asia region. The slope of the rise in liver cancer mortality rate for Western Pacific region was 3-4 times higher than the other regions. 2-pattern growth mixture model was estimated as the best model. The Western Pacific region with annual increase of 0.20 in the liver cancer mortality rate was in the first pattern and the other 5 regions including Africa region, Eastern Mediterranean region, European region, region of the Americas, and South-East Asia region with annual increase of 0.05 in liver cancer mortality rate belonged to the second pattern.Conclusion:Observed pattern in the Western Pacific region is not favorable. Taking into account a set of urgent prevention actions to control mortality rate of liver cancer in this region seems necessary. 相似文献
19.
Mohammad Hosein Farzaei Roodabeh Bahramsoltani Ali Ghobadi Fatemeh Farzaei Fariba Najafi 《中医杂志(英文版)》2017,37(5):710-720
Current paper reviews the pharmacological activities, therapeutic indications and phytochemicals of M. longifolia. This herb has been consumed traditionally for the treatment of various diseases, including gastrointestinal disorders, respiratory disorders, infectious diseases, inflammatory diseases, as well as menstrual disorders. In the modern era, various pharmacological activities have been confirmed for M. longifolia, such as anti-parasitic, antimicrobial, anti-insect, antimutagenic, antinociceptive, anti-inflammatory, antioxidant, keratoprotective, hepatoprotective, anti-diarrhea, and spasmolytic effects. The plant showed therapeutic benefits in irritable bowel syndrome, amenorrhea and oligomenorrhea, and oxidative stress-associated diseases as well. A vast variety of natural components such as flavonoids, phenolic acids, cinnamates, ceramides, sesquiterpenes, terpenes, and terpenoids have been suggested to be responsible for the pharmacological action of M. longifolia. These natural products can be considered as novel medicinal sources for developing new drugs. Further investigations to explore therapeutic efficacy, tolerability, and pharmaceutical properties of M. longifolia phytochemical agents are recommended. 相似文献
20.
Mehdi Nouraie Fatemeh Hosseinkhah Hassan Brim Behrouz Zamanifekri Duane T. Smoot Hassan Ashktorab 《Digestive diseases and sciences》2010,55(5):1442-1449