Stabilization of anterior mandibular fracture using different osteosynthesis devices: perioperative clinical notes

Oral and Maxillofacial Surgery - There is still no definitive consensus about the ideal technique in the treatment of anterior mandibular fractures. Therefore, this study aimed to determine...     

Differential time to positivity: Vascular catheter drawn cultures for the determination of catheter-related bloodstream infection

Abstract Background: Vascular access catheter-related infections are common. The purpose of this study was to evaluate the accuracy of differential time to positivity (DTP) comparing 2 blood cultures drawn through different lumens of a multi-lumen central venous catheter (CVC DTP) for the diagnosis of catheter-related bloodstream infection (CRBSI). Methods: This study was performed at a single institution (Health Sciences Centre, Winnipeg, Manitoba, Canada). Microbiology laboratory blood culture records for the period January to November 2009 were retrospectively reviewed. All adult patients with a positive peripheral blood culture and a minimum of 2 positive central line cultures (same organism) drawn from separate lumens of a multi-lumen CVC, all obtained at the same time on the same day, were included in the study. DTP supporting CRBSI diagnosis was defined as a difference in time to positivity of ≥?2 h between a peripheral blood culture and a CVC blood culture (peripheral DTP), or between 2 CVC blood cultures from different lumens of a multi-lumen catheter (CVC DTP). Peripheral DTP was used as the reference standard for CRBSI diagnosis. Results: Thirty-five episodes of bacteremia from 33 patients were included in this study. CVC DTP had a sensitivity of 76.5% and a specificity of 88.9% for CRBSI diagnosis, using peripheral DTP as the reference standard. Conclusions: These data suggest that CVC DTP may be of benefit in the diagnosis of CRBSI. Further study is required to better define the patient population/catheter type for which CVC DTP would be of greatest benefit.     

Inhibitory Effects of Pepstatin A and Mefloquine on the Growth of Babesia Parasites

We evaluated the inhibitory effects of pepstatin A and mefloquine on the in vitro and in vivo growths of Babesia parasites. The in vitro growth of Babesia bovis, B. bigemina, B. caballi, and B. equi was significantly inhibited (P < 0.05) by micromolar concentrations of pepstatin A (50% inhibitory concentrations = 38.5, 36.5, 17.6, and 18.1 μM, respectively) and mefloquine (50% inhibitory concentrations = 59.7, 56.7, 20.7, and 4 μM, respectively). Furthermore, both reagents either alone at a concentration of 5 mg/kg or in combinations (2.5/2.5 and 5/5 mg/kg) for 10 days significantly inhibited the in vivo growth of B. microti in mice. Mefloquine treatment was highly effective and the combination treatments were less effective than other treatments. Therefore, mefloquine may antagonize the actions of pepstatin A against babesiosis and aspartic proteases may play an important role in the asexual growth cycle of Babesia parasites.     

Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies

相似文献   

Influence of high expansion dental stone used as investing medium on the changes in occlusal vertical dimension of complete dentures

Problem statementDespite advances in materials and techniques, complete dentures made of acrylic resin experience an increase in the occlusal vertical dimension (OVD) during processing. Many factors that affect the OVD of complete dentures are known. However, no study has examined the effect of using high-expansion dental stone (type V) as an investing material on the OVD.PurposeThis study investigated the effects of using a high-expansion dental stone as an investing material on changes in the OVD of complete dentures.Material and methodsTwenty sets of simulated upper and lower dentures were processed by the compression molding technique. Specimens were equally divided into 2 groups. In the dental stone type III (DST III) group, the lower, middle, and upper parts of a flask were filled with DST III. In the dental stone type V (DST V) group, the procedure was the same as in the DST III group, except that the middle layer was made of high-expansion DST V. Changes in the OVD were measured before and after denture processing. Collected data were analyzed with t-test statistics. Differences were considered statistically significant at the 95% confidence level.ResultsBoth groups showed a small increase in the OVD as a result of processing, but the OVD increase was significantly less in the DST V group compared to the DST III group.ConclusionHigh-expansion DST V can be recommended as an investing material to reduce the increase in the OVD that may occur while processing complete dentures.