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排序方式: 共有131条查询结果,搜索用时 15 毫秒
31.
Changes in tissue-oxidative stress markers in an experimental model of laparoscopic donor nephrectomy 总被引:5,自引:0,他引:5
Akbulut G Serteser M Polat C Köken T Aktepe F Yilmaz S Gokçe C Gökçe O 《Transplantation》2002,74(12):1768-1772
BACKGROUND: Laparoscopic donor nephrectomy (LDN) is associated with prolonged warm ischemia, which could potentially increase oxidative stress in the graft. Because pneumoperitoneum (Pp) used to facilitate LDN impairs renal perfusion, it could augment the effects of warm ischemia. Our experimental, randomized, controlled study with blind outcome assessment is the first to address this possibility. METHODS: Wistar-Albino rats were randomized to 4 groups. Controls were subjected to a sham operation; the remainder were subjected to Pp with or without warm ischemia of differing durations. The kidneys were removed at the end of each experiment. The concentrations of malondialdehyde (MDA), protein carbonyl, and sulfhydryl groups and the activities of superoxide dismutase (SOD) and catalase were measured in renal samples as markers of oxidative stress. Renal samples were also evaluated histopathologically using light microscopy. RESULTS: Pp promoted oxidative stress in renal tissues, with an increase of MDA and protein carbonyls and a decrease in protein sulfhydryls and SOD activity. Warm ischemia exerted an additive effect on Pp-associated oxidative stress only when sustained for 10 minutes. These changes occurred in the absence of light-microscopic evidence of overt tissue damage. CONCLUSION: In an experimental model resembling LDN, Pp and 10 minutes of warm ischemia emerged as additive factors with respect to causing increased oxidative stress in the kidney. Because these effects imply subtle injury not only in the harvested kidneys of live donors but also in the kidneys the donors retain, avoiding Pp and warm ischemia above 5 minutes during LDN appears advisable. 相似文献
32.
A case of childhood pulmonary haemosiderosis with a fourfold increase in mast cells in the lung is described. This finding is discussed in relation to the pathogenesis of the disease. Comparison is made with controls, and the use of disodium cromoglycate is advocated. 相似文献
33.
Noémi Dahan‐Oliel MSc PhD Sarah Cachecho MSc Douglas Barnes MD Tanya Bedard BSc MPH Ann M. Davison PhD Klaus Dieterich MD PhD Maureen Donohoe DPT Alicja Fąfara MSc PhD Reggie Hamdy MB MSc FRCSC Helgi T. Hjartarson MD Naimisha S. Hoffman DDS Eva Kimber MD PhD Igor Komolkin MD PhD Ruth Lester OBE FRCS Eva Pontén MD PhD Harold J. P. van Bosse MD Judith G. Hall MD OC RSC CAHS 《American journal of medical genetics. Part C, Seminars in medical genetics》2019,181(3):288-299
Arthrogryposis multiplex congenita (AMC) has been described and defined in thousands of articles, but the terminology used has been inconsistent in clinical and research communities. A definition of AMC was recently developed using a modified Delphi consensus method involving 25 experts in the field of AMC from 8 countries. Participants included health care professionals, researchers, and individuals with AMC. An annotation of the definition provides more in‐depth explanations of the different sentences of the AMC definition and is useful to complement the proposed definition. The aim of this study was to provide an annotation of the proposed consensus‐based AMC definition. For the annotation process, 17 experts in AMC representing 10 disciplines across 7 countries participated. A paragraph was developed for each sentence of the definition using an iterative process involving multiple authors with varied and complementary expertise, ensuring all points of view were taken into consideration. The annotated definition provides an overview of the different topics related to AMC and is intended for all stakeholders, including youth and adults with AMC, their families, and clinicians and researchers, with the hopes of unifying the understanding of AMC in the international community. 相似文献
34.
Margolis RL; Stine OC; McInnis MG; Ranen NG; Rubinsztein DC; Leggo J; Brando LV; Kidwai AS; Loev SJ; Breschel TS; Callahan C; Simpson SG; DePaulo JR; McMahon FJ; Jain S; Paykel ES; Walsh C; DeLisi LE; Crow TJ; Torrey EF; Ashworth RG; Macke JP; Nathans J; Ross CA 《Human molecular genetics》1996,5(5):607-616
The two most consistent features of the diseases caused by trinucleotide
repeat expansion-neuropsychiatric symptoms and the phenomenon of genetic
anticipation-may be present in forms of dementia, hereditary ataxia,
Parkinsonism, bipolar affective disorder, schizophrenia and autism. To
identify candidate genes for these disorders, we have screened human brain
cDNA libraries for the presence of gene fragments containing polymorphic
trinucleotide repeats. Here we report the cDNA cloning of CAGR1, originally
detected in a retinal cDNA library. The 2743 bp cDNA contains a 1077 bp
open reading frame encoding 359 amino acids. This amino acid sequence is
homologous (56% amino acid identify and 81% amino acid conservation) to the
Caenorhabditis elegans cell fate-determining protein mab-21. CAGR1 is
expressed in several human tissues, most prominently in the cerebellum, as
a message of approximately 3.0 kb. The gene was mapped to 13q13, just
telomeric to D13S220. A 5'-untranslated CAG trinucleotide repeat is highly
polymorphic, with repeat length ranging from six to 31 triplets and a
heterozygosity of 87-88% in 684 chromosomes from several human populations.
One allele from an individual with an atypical movement disorder and
bipolar affective disorder type II contains 46 triplets, 15 triplets longer
than any other allele detected. Though insufficient data are available to
link the long repeat to this clinical phenotype, an expansion mutation of
the CAGR1 repeat can be considered a candidate for the etiology of
disorders with anticipation or developmental abnormalities, and
particularly any such disorders linked to chromosome 13.
相似文献
35.
36.
Gumus II Keskin EA Kiliç E Aker A Kafali H Turhan NO 《Archives of gynecology and obstetrics》2008,278(3):241-244
Objective To estimate the diagnostic value of hysteroscopy and hysterosonography in endometrial pathologies in asymptomatic postmenopausal
women.
Materials and methods In this prospective study, 77 asymptomatic postmenopausal women that had a suspicion of endometrial abnormalities based upon
transvaginal ultrasonography were studied. The patients underwent transvaginal ultrasonography and hysterosonography. All
patients then had office diagnostic hysteroscopy or operative hysteroscopy. The final diagnosis was made by operative hysteroscopy
with resection and excision of the lesions or endometrial biopsy with vacuum curettage. Sensitivity, specificity, positive
predictive value and negative predictive value of transvaginal ultrasonography, hysterosonography and diagnostic hysteroscopy
were calculated.
Results The patients’ age ranged from 45 to 80. The most common frequent abnormalities were endometrial hyperplasia in transvaginal
ultrasonography (62.33%), endometrial polyp in sonohisterography (57.14%), and also endometrial polyp in diagnostic hysteroscopy
(51.94%). Transvaginal ultrasonography revealed a sensitivity of 59.7% and a specificity of 35.5%. Sonohysterography revealed
a sensitivity of 88.8% and a specificity of 84.4%. Diagnostic hysteroscopy revealed a sensitivity of 91% and a specificity
of 82%.
Conclusion Hysterosonography showed very good agreement with hysteroscopy for the diagnosis of endometrial abnormalities in asymptomatic
postmenopausal women. In asymptomatic postmenopausal women that had a suspicion of endometrial abnormalities based upon transvaginal
ultrasonography should undergo both hysterosonography and hysteroscopy. 相似文献
37.
During the past three decades, there has been a gradual evolution toward less invasive surgery. In breast surgery, the introduction of vacuum-assisted biopsy devices with larger bore cannulae has extended their role to include a therapeutic as well as a diagnostic function. The present article focuses on the innovative use of vacuum-assisted biopsy devices in the treatment of male mammary hypertrophy. 相似文献
38.
Intravascular papillary endothelial hyperplasia (IPEH) is a rare benign endothelial proliferation that bears a remarkable resemblance to angiosarcoma. We report a case of cutaneous IPEH in the thumb of a seven-year old girl which was successfully treated with excision. The relevant literature is reviewed and histopathological features, differential diagnosis and natural history of the lesion are discussed. 相似文献
39.
Although human parvovirus B19 (PVB19) is mainly known to be the causative agent of fifth disease, it is also important in the etiopathogenesis of various hematologic disorders. Recently, its role in the occurrence of chronic anemia and pancytopenia in immunocompromised patients has been revealed. In this study, the authors searched for the presence of PVB19 in a group of patients with idiopathic thrombocytopenic purpura (ITP). The PVB19 DNA was determined by nested PCR, and serologic responses to the virus were evaluated by ELISA. Viral genome was detected by PCR in the sera of 9 of the 19 patients. The IgM and IgG positivities were 57 and 73% in the patients, respectively. These results suggest that PVB19 is associated with ITP nearly in half of the patients and its pathogenetic role in the cases of ITP needs further consideration. 相似文献
40.
Not only is Group A beta-hemolytic Streptococcus (GAS) the most frequent cause of bacterial pharyngitis, it is also the culprit in various skin and systemic infections, acute rheumatic fever, post streptococcal glomerulonephritis, and other disorders and complications. A new, ready-to-use media, Dio-Bacit, in a two section plate containing 5% sheep blood agar on one side and sheep blood agar with bacitracin (2 microg/ml) on the other was compared for its efficiency in identifying GAS with bacitracin and bacitracin + sulphamethaxazole / trimethoprim disk tests applied after isolation of beta-hemolytic colonies. We also used the latex-agglutination test as the gold standard method for differentiating GAS from streptococci belonging to other groups. Compared with the latex-agglutination test, we found the sensitivity and specificity of the Dio-Bacit method to be 92.0% and 96.9%, respectively. Dio-Bacit plates provide an easy and very useful way to identify GAS within one day, saving time, labor, and money for routine diagnostic microbiology laboratories. 相似文献