全文获取类型
收费全文 | 62336篇 |
免费 | 3011篇 |
国内免费 | 323篇 |
专业分类
耳鼻咽喉 | 870篇 |
儿科学 | 1173篇 |
妇产科学 | 974篇 |
基础医学 | 8255篇 |
口腔科学 | 1609篇 |
临床医学 | 4183篇 |
内科学 | 15285篇 |
皮肤病学 | 1110篇 |
神经病学 | 5005篇 |
特种医学 | 2259篇 |
外科学 | 10659篇 |
综合类 | 282篇 |
一般理论 | 2篇 |
预防医学 | 1998篇 |
眼科学 | 1185篇 |
药学 | 4756篇 |
中国医学 | 111篇 |
肿瘤学 | 5954篇 |
出版年
2023年 | 313篇 |
2022年 | 656篇 |
2021年 | 1105篇 |
2020年 | 584篇 |
2019年 | 801篇 |
2018年 | 1043篇 |
2017年 | 804篇 |
2016年 | 989篇 |
2015年 | 1060篇 |
2014年 | 1447篇 |
2013年 | 1785篇 |
2012年 | 2905篇 |
2011年 | 3207篇 |
2010年 | 1831篇 |
2009年 | 1594篇 |
2008年 | 2973篇 |
2007年 | 3263篇 |
2006年 | 3191篇 |
2005年 | 3297篇 |
2004年 | 3272篇 |
2003年 | 3335篇 |
2002年 | 3166篇 |
2001年 | 1888篇 |
2000年 | 1992篇 |
1999年 | 1803篇 |
1998年 | 852篇 |
1997年 | 680篇 |
1996年 | 648篇 |
1995年 | 556篇 |
1994年 | 507篇 |
1993年 | 453篇 |
1992年 | 1267篇 |
1991年 | 1060篇 |
1990年 | 1025篇 |
1989年 | 1052篇 |
1988年 | 945篇 |
1987年 | 923篇 |
1986年 | 879篇 |
1985年 | 861篇 |
1984年 | 620篇 |
1983年 | 497篇 |
1982年 | 286篇 |
1980年 | 249篇 |
1979年 | 534篇 |
1978年 | 322篇 |
1977年 | 297篇 |
1975年 | 239篇 |
1974年 | 249篇 |
1971年 | 249篇 |
1969年 | 244篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
Toshihiko Imakiire Yuichi Kikuchi Muneharu Yamada Taketoshi Kushiyama Keishi Higashi Naomi Hyodo Kojiro Yamamoto Takashi Oda Shigenobu Suzuki Soichiro Miura 《Hypertension research》2007,30(7):635-642
The mechanisms of hypertensive nephrosclerosis are not fully understood. In experimental models of the disease, inflammatory reactions such as macrophage infiltration play an important role. In human hypertensive nephrosclerosis, however, there have been few studies examining the role of inflammation histologically. We investigated whether the number of infiltrating macrophages was increased in human hypertensive nephrosclerosis, and evaluated the effects of a blockade of the renin-angiotensin system on clinical and histological findings. We examined macrophage infiltration using immunohistochemistry in renal biopsy specimens obtained from 16 patients with hypertensive nephrosclerosis, 5 patients with IgA nephropathy, 5 patients with membranous nephropathy, and 5 patients with minimal change nephrotic syndrome. The number of infiltrating macrophages in glomeruli was significantly larger in the patients with hypertensive nephrosclerosis than in those with minimal change nephrotic syndrome. The patients with hypertensive nephrosclerosis were divided into groups based on their use of antihypertensive agents at the time of renal biopsy. We investigated the effects of antihypertensive agents on clinical findings, macrophage infiltration, and monocyte chemoattractant protein-1 expression. There was no difference in clinical findings between the hypertensive groups. The numbers of infiltrating macrophages and monocyte chemoattractant protein-1-positive cells in glomeruli were significantly smaller in patients treated with an angiotensin-converting enzyme inhibitor or angiotensin II type 1 receptor blocker, whereas calcium channel blockers had no influence on histological findings. In conclusion, inflammation is involved in the progression of human hypertensive nephrosclerosis and the inflammatory process is inhibited by blocking the renin-angiotensin system. 相似文献
102.
Mikio Mikami Chisei Tei Kyoko Takehara Shinichi Komiyama Atsushi Suzuki Takanori Hirose 《International journal of gynecological pathology》2003,22(2):205-208
A 38-year-old female presented with a lower abdominal mass. During the operation the mass was found to be retroperitoneal and was excised. Gross examination revealed a mucin-containing cystic lesion with a mural nodule. On microscopic examination, the cystic areas were lined by an invasive mucinous adenocarcinoma and the nodule was composed of an anaplastic sarcomatoid tumor that was immunoreactive for cytokeratin. This present case is the 21st example of a retroperitoneal primary mucinous cystadenocarcinoma and the fourth with a mural nodule. Three of four cases with a mural nodule, including our case, had a rapidly fatal outcome. 相似文献
103.
Takuro Yoshikawa Yasuyuki Suzuki Yasuhiro Fujino Keitaro Kakinoki Shiri Li Tadahiro Goto Tomohiro Tanaka Ippei Matsumoto Tetsuya Sakai Yasuki Tanioka Hiroshi Yokozaki Yoshikazu Kuroda 《American journal of transplantation》2005,5(9):2135-2142
Small bowel transplantation (SBT) is associated with a high incidence of infectious complications because of ischemia/reperfusion (I/R) mucosal injury concomitant with potent immunosuppression. In this study, we evaluated whether the cavitary two-layer method (cTLM) could reduce I/R injury and allow early mucosal restoration, particularly after prolonged preservation and transplantation. Canine heterotopic segmental SBT was performed immediately without preservation (group 1), after 24-h preservation in UW solution (group 2) or by the cTLM (group 3). The graft samples were taken 1 h after reperfusion and on days 1, 4 and 7. We assessed graft mucosa with detailed microscopic and electromicroscopic analyses. In Group 3, histological injury and cell apoptosis after transplantation were significantly alleviated and rapidly recovered to a similar level of group 1. The mucosal restoration was morphologically completed within 4 days. In contrast, in group 2, more pronounced mucosal injury and delayed recovery were noted. Crypt cell proliferation activity was well maintained in groups 1 and 3 throughout the experimental period. Our ultrastructural analysis suggested that mitochondrial integrity achieved by the cTLM was a basal mechanism under the prompt mucosal restoration. The cTLM could reduce I/R injury, facilitate mucosal regeneration and restore the nearly normal structure early after SBT. 相似文献
104.
105.
Yasuhiro Takikawa Yuki Yasumi Akihiro Sato Ryujin Endo Kazuyuki Suzuki Yasuki Mori Hidetoshi Akasaka Yasuhiro Miura Takashi Sawai Hiroaki Okamoto 《Hepatology research》2007,37(2):158-165
A 65-year-old Japanese man was hospitalized because of acute hepatitis and severe cholestasis due to hepatitis E virus (HEV) infection combined with a drug reaction to a cold preparation. He died of disseminated intravascular coagulation and severe intestinal bleeding due to systemic cytomegalovirus reactivation following the development of severe eruptions with marked eosinophilia due to drug hypersensitivity to taurine and ursodeoxycholate preparations. The close interaction between viral infection or reactivation and drug hypersensitivity was considered as a pathophysiology in this case, which emphasizes the need for further study of the immunological mechanism of the interaction. 相似文献
106.
D Craig Willcox Bradley J Willcox Sanae Shimajiri Sayuri Kurechi Makoto Suzuki 《The American journal of geriatric psychiatry》2007,15(3):252-256
OBJECTIVE: This study retrospectively explored the late-life functional status of Okinawan centenarians. METHODS: Activities of daily living were measured retrospectively at five time points (10, 5, 3, and 1 year prior and present) for 22 centenarians in relation to seven physical, two sensory, and two cognitive functions using the Inoue Index. RESULTS: In all, 82% of individuals were still functioning independently at a mean age of 92 years and almost two-thirds were still functioning independently at a mean age of 97 years. CONCLUSION: Preliminary analyses suggest high functional status in Okinawan centenarians throughout their 90 s. The genetic and environmental factors contributing to this successful aging phenomenon deserve further investigation. 相似文献
107.
108.
Makiho Sekiuchi Kimimasa Nakabayashi Tomohumi Marumo Yoshihiro Arimura Akira Yamada 《Ryūmachi》2003,43(4):696-702
A 65-year old female, who had been suffered from rheumatoid arthritis, was admitted to our hospital because of fever, oral ulcers, perianal skin ulcers, petechiae in the both legs, hepatosplenomegaly and cervical lymphadenopathy. Her laboratory data showed severe anemia, leukocytopenia, and thrombocytopenia as well as low PT activity, prolonged APTT, decreased fibrinegen and elevated FDP. In addition to raised values of liver enzymes and triglyceride, marked elevation of several cytokines were found. IgM and IgG class antibodies to cytomegalovirus were demonstrated positive and their titers were 2.60 and 938.0, respectively. The study for the aspiration of bone marrow revealed hemophagocytosis of erythrocytes, leukocytes and thrombocytes. Based upon these findings, she was diagnosed as having hemophagocytic syndrome associated with cytomegalovirus infection. Steroid treatment inducing mini-pulse therapy was introduced to her and bought full recovery from the illness. The association of hemophagocytic syndrome to rheumatoid arthritis was reviewed in the literature and five cases were documented to have good prognosis with steroid treatment. 相似文献
109.
Takuya Toyama Norihiko Ohura Masakazu Kurita Akira Momosawa Kiyonori Harii 《Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi》2006,40(6):329-334
We have investigated the effects of short-contact topical application of tretinoin using 16 male db/db mice by creating two full-thickness wounds on the skin of the back. A 0.1% tretinoin aqueous gel was applied to one wound for five minutes daily for five successive days while only aqueous gel was applied to the other (control). The mean (SD) percentage surface area unhealed before and after treatment were 0.88 (0.3) and 0.64 (0.15). In tretinoin-treated mice and non-treated mice (controls), the mean (SD) thicknesses of granulation were 1.383 (697) micro m and 683 (413) micro m, the density of capillary vessels in granulation was 12.2 (5.5)% and 5.7 (3.9)%, respectively. Differences between the two groups were significant for each variable. Wound healing was accelerated with short-contact topical application of tretinoin in db/db mice. 相似文献
110.
Positron emission tomography was performed on six patients with Rett syndrome to investigate cerebral blood flow and oxygen metabolism, and the results were compared with the concurrent clinical status of the patients. The cerebral metabolic rate of oxygen (CMRO2) was low in five patients, and oxygen extraction fraction was low in four patients; both had a tendency to decline with advancing age. Although the cause is unknown, it is suggested that impaired oxidative metabolism exists in Rett syndrome. An analysis of the distribution among brain regions showed that the ratios of values for the frontal cortex to those for the temporal cortex for both cerebral blood flow and CMRO2 were lower than those for the controls, which may indicate the loss of hyperfrontality in Rett syndrome. 相似文献