全文获取类型
收费全文 | 3114篇 |
免费 | 173篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 60篇 |
儿科学 | 48篇 |
妇产科学 | 20篇 |
基础医学 | 302篇 |
口腔科学 | 51篇 |
临床医学 | 183篇 |
内科学 | 730篇 |
皮肤病学 | 29篇 |
神经病学 | 174篇 |
特种医学 | 96篇 |
外科学 | 918篇 |
综合类 | 17篇 |
预防医学 | 87篇 |
眼科学 | 60篇 |
药学 | 137篇 |
中国医学 | 4篇 |
肿瘤学 | 383篇 |
出版年
2023年 | 22篇 |
2022年 | 40篇 |
2021年 | 65篇 |
2020年 | 54篇 |
2019年 | 60篇 |
2018年 | 60篇 |
2017年 | 70篇 |
2016年 | 64篇 |
2015年 | 77篇 |
2014年 | 101篇 |
2013年 | 97篇 |
2012年 | 143篇 |
2011年 | 183篇 |
2010年 | 92篇 |
2009年 | 102篇 |
2008年 | 174篇 |
2007年 | 133篇 |
2006年 | 128篇 |
2005年 | 124篇 |
2004年 | 107篇 |
2003年 | 113篇 |
2002年 | 131篇 |
2001年 | 92篇 |
2000年 | 79篇 |
1999年 | 86篇 |
1998年 | 39篇 |
1997年 | 35篇 |
1996年 | 35篇 |
1995年 | 38篇 |
1994年 | 31篇 |
1993年 | 18篇 |
1992年 | 59篇 |
1991年 | 76篇 |
1990年 | 83篇 |
1989年 | 68篇 |
1988年 | 67篇 |
1987年 | 60篇 |
1986年 | 62篇 |
1985年 | 46篇 |
1984年 | 43篇 |
1983年 | 41篇 |
1982年 | 9篇 |
1981年 | 9篇 |
1979年 | 20篇 |
1978年 | 12篇 |
1977年 | 13篇 |
1975年 | 3篇 |
1972年 | 3篇 |
1967年 | 4篇 |
1966年 | 9篇 |
排序方式: 共有3299条查询结果,搜索用时 0 毫秒
61.
Hisashi Kaneda Masaki Shimizu Kazuhide Ohta Katsumi Ushijima Yoshimitsu Gotoh Kenichi Satomura Takuhito Nagai Mikiya Fujieda Masashi Morooka Takuji Yamada Masayoshi Yamada Naohiro Wada Mari Takaai Yukiya Hashimoto Osamu Uemura 《Clinical and experimental nephrology》2016,20(5):757-763
Background
The present study aimed to obtain information enabling optimisation of the clinical effect of mizoribine (MZR) in pediatric patients with kidney disease.Methods
A total of 105 pediatric patients with kidney disease treated at our institutions were enrolled. Kidney transplant patients were excluded. Population pharmacokinetic analysis of MZR was performed based on serum concentration data. Area under the curve from time zero to infinity (AUC∞) and maximal concentration (C max) were calculated by Bayesian analysis.Results
In children, the appearance of MZR in the blood tended to be slower and the subsequent rise in blood concentration tended to be more sluggish, compared to healthy adults. Apparent volume of distribution and oral clearance were also higher in children compared to adults. A significant positive correlation was observed between patient age and AUC∞. There were significant differences of AUC∞ and C max by age group. No relationship was observed between the administration method of MZR and serum concentration.Conclusion
The pharmacokinetics of MZR was different in children compared to adults. To obtain the expected clinical efficacy, the regular MZR dosage schedule (2–3 mg/kg/day) might be insufficient for pediatric patients. In particular, younger patients might require a higher dosage of MZR per unit body weight.62.
Matsuura K Tanaka Y Takagi K Hiramatsu K Kani S Gotoh T Wakimoto Y Joh T Mizokami M 《Rinsho byori. The Japanese journal of clinical pathology》2007,55(11):983-988
The Abbott Real Time HCV assay (lower limit of detection 12 IU/ml) was developed as a highly sensitive HCV RNA quantitative assay using real-time detection PCR(RTD-PCR). We assessed whether the new assay more effectively predicts sustained virological response (SVR) than conventional PCR (PCR) in 38 chronic hepatitis patients infected with HCV genotype 1b and treated with pegylated interferon alpha2b plus ribavirin. Sixteen patients reached SVR, 10 patients relapsed, 9 patients did not respond, 3 patients discontinued treatment. Positive predictive value (PPV) for SVR of undetectable HCV RNA at W4, 8, 12 by RTD-PCR and PCR was (100% vs. 100% at W4), (100% vs. 100% at W8), (83.3% vs. 72.7% at W12). HCV RNA undetectable at W12 had a higher PPV for SVR when measured by RTD-PCR than by conventional PCR. 相似文献
63.
64.
65.
66.
67.
Daisuke Gotoh MD PhD Nobutaka Shimizu MD PhD Naoki Wada MD PhD Katsumi Kadekawa MD PhD Tetsuichi Saito MD Shinsuke Mizoguchi MD PhD Yosuke Morizawa MD PhD Shunta Hori MD PhD Makito Miyake MD PhD Kazumasa Torimoto MD PhD William C. de Groat PhD Kiyohide Fujimoto MD PhD Naoki Yoshimura MD PhD 《Neurourology and urodynamics》2020,39(8):2120-2127
68.
69.
Ohira Masafumi Yoshizumi Tomoharu Yugawa Kyohei Kosai-Fujimoto Yukiko Inokuchi Shoichi Motomura Takashi Mano Yohei Toshima Takeo Itoh Shinji Harada Noboru Ikegami Toru Soejima Yuji Taketomi Akinobu Mori Masaki 《Surgery today》2020,50(4):379-388
Surgery Today - Inflammatory biomarkers such as the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) are reportedly predictive of the... 相似文献