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21.
Atsushi Takai Yoshihiro Okabe Nobuhiro Aoki Mariko Takada Shuji Yamamoto Naoya Kimoto Mikio Fujita Akihiko Okada Chiharu Kawanami Yukinobu Takimoto Akio Orino 《Nihon Shokakibyo Gakkai zasshi》2007,104(10):1498-1503
A 77-year-old man, who underwent segmental pancreatectomy for intraductal papillary mucinous adenoma in 2001, was referred to our hospital with complaints of hematemesis and melena on January, 2004. Emergency upper gastrointestinal endoscopy showed a pulsating submucosal protrusion in the duodenal bulb, which was identified as a gastroduodenal arterial aneurysm measuring 1.5cm on abdominal CT imaging. Transcatheter arterial embolization of the aneurysm with metallic coils was successfully performed. Periodically repeated endoscopic examination has revealed the coils protruding into the duodenal lumen without any serious complication. 相似文献
22.
23.
Koichi Nishimura Takashi Hajiro Toru Oga Mitsuhiro Tsukino Susumu Sato Akihiko Ikeda 《The Journal of asthma》2005,41(2):141-146
Simple and concise measures for health status are desirable in clinical practice. The Asthma Bother Profile (ABP), which consists of 23 items, has been developed to assess how much asthma bothers patients. The Airways Questionnaire 20 (AQ20) is a simple instrument which consists of 20 items. The purpose of this study was to investigate how the ABP and AQ20 evaluate the health status of patients with asthma. A total of 166 patients with chronic asthma (age: 48 ± 16 yr, 77 males) completed pulmonary function testing, measurement of airway hyperresponsiveness, dyspnea rating, assessments of their anxiety and depression (HADS; Hospital Anxiety and Depression Scale), and assessments of their health status. The health status was assessed using the ABP, AQ20, the short-form 36 health survey questionnaire (SF-36), the Living With Asthma Questionnaire (LWAQ) and the Asthma Quality of Life Questionnaire (AQLQ). The Japanese version of the ABP included only 15 'bother' items out of the original 23 items due to cultural differences. The scores on the ABP were widely distributed, whereas the scores on the AQ20 were skewed towards the milder end of the scale. The ABP had a strong correlation with the Avoidance and Distress constructs on the LWAQ, and Anxiety and Depression on the HADS (Rs = 0.56 ∼ 0.79), and its strongest correlation with the General Health (Rs = - 0.64) scale among the 8 subscales on the SF-36. The AQ20 had a less significant correlation with the LWAQ, AQLQ, and SF-36 than the ABP. The ABP and AQ20 were short and simple to complete, and both measures could easily be used in clinical practice. The ABP can evaluate patients more specifically with respect to distress and bother than the AQ20. 相似文献
24.
25.
Are cytokines possible mediators of cancer cachexia? 总被引:1,自引:0,他引:1
Yoshikazu Noguchi Takaki Yoshikawa Akihiko Matsumoto Gösta Svaninger Johan Gelin 《Surgery today》1996,26(7):467-475
The possible role of cytokines in the development of cancer cachexia was reviewed from the literature. Tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, IL-6, interferon (IFN)-gamma and leukemia inhibitory factor (LIF) can elicit many but not all host changes seen in cancer cachexia, including loss of appetite, loss of body weight, and the induction of acute-phase protein synthesis. However, these cytokines are not always demonstrated in the circulation of the cancer patients. The inability to detect circulating cytokines may be due to their low rate of production, their short half-life and rapid clearance from plasma, or their mode of action (autocrine or paracrine). Different cytokines are induced to stimulate the same response. This is very different from hormonal regulation, where a hormone acts on a cell directly through a specific receptor without depending on other mediators. Specific antibodies including anti-IFN-gamma, anti-TNF and anti-IL-6 antibodies, as well as the cyclooxygenase inhibitor indomethacin, have been used to reverse cancer cachexia. Overlapping physiologic activities make it unlikely that a single substance is the sole cause of cancer cachexia. It is hoped that further investigation on other cytokines and their possible relationships with hormones will help to clarify the mechanisms of cancer cachexia in the near future.This work was supported by a grant from the Japan-Sweden Foundation in 1991. 相似文献
26.
Seiji Kinugasa Shuichi Tachibana Manpei Kawakami Tatsuhiko Orino Ryuichi Yamamoto Shinjiro Sasaki 《Surgery today》1998,28(3):335-338
(Received for publication on Nov. 14, 1996; accepted on May 12, 1997) 相似文献
27.
Keigo Kohara Tomio Ono Keiko Tominaga-Yoshino Tomokazu Shimonaga Seiichi Kawashima Akihiko Ogura 《Brain research》1998,809(2):285
Neurons survive when their activity is maintained. An influential hypothesis on the cellular mechanism underlying this phenomenon is that there is an appropriate range of intracellular Ca2+ concentration ([Ca2+]i) for survival. The rat cerebellar granule neuron in culture serves as the most often used model system for the analysis of activity-dependent survival, since it does not survive unless an excitant (KCl or glutamate) is added to the culture medium. Against the above-mentioned hypothesis, we found in our previous examination no difference between steady-state [Ca2+]i in granule neurons cultured under high KCl (i.e., survival) and low KCl (i.e., death) conditions. In this report, we present the quantitative background of unchanged [Ca2+]i between the two culture conditions. Influx of Ca2+ due predominantly to L-type voltage-dependent calcium channels was higher in high KCl cultures than in low KCl cultures. At the same time, efflux of Ca2+ due to the activity of Ca2+/Na+ antiport was also higher in high KCl cultures. Additionally, we found that the endocytotic activity was greater in high KCl cultures than in low KCl cultures, as monitored by the rate of uptake of horseradish peroxidase added to medium. Since the uptake was blocked by an internal Ca2+ chelator, the increased endocytotic activity in high KCl cultures might be a consequence of the enhanced Ca2+ turnover. 相似文献
28.
Possible involvement of arachidonic acid metabolism in phenobarbital promotion of hepatocarcinogenesis 总被引:8,自引:4,他引:4
Denda Ayumi; Ura Hitoshi; Tsujiuchi Toshifumi; Masahiro Tsutsumi; Eimoto Hiroyuki; Takashima Yoshiharu; Kitazawa Shunji; Kinugasa Tetsuo; Konishi Yoich 《Carcinogenesis》1989,10(10):1929-1935
The effects of inhibitors of arachidonic acid metabolism andantioxidants on the rat liver tumor promotion activity of phenobarbital(PB) were assessed using the enzyme-altered focus as the end-pointlesion. Fischer 344 male rats were initiated with N-nitrosodiethylamine(200 mg/kg) and then divided into five groups placed on basaldiet, diet containing 0.05% PB, diet containing 0.05% PB plus0.75%, 1% or 1.5% levels of various inhibitors of arachidonicacid metabolism or antioxidants, or diet containing 1% or 1.5%inhibitors or antioxidants alone for 10 weeks, and then killed.-Bromo phenacyl bromide, an inhibitor of phospholipase A2 significantly inhibited the promotion activity of PB at dose levelsof 0.75% and 1.5%, reaching plateau at 0.75%. Both quercetin,an inhibitor of lipoxygenase, and morin, a dual inhibitor oflipoxygenase-cyclooxygenase, significantly reduced the promotionactivity of PB at the 1.5% but not 0.75% dose levels. Moreover,acetylsalicylic acid, an inhibitor of cyclooxygenase dose-dependentlyinhibited the promotion activity of PB. Among the antioxidantsinvestigated, vitamin E did not affect, but n-propyl gallateand ethoxyquin exerted a dose-dependent inhibition of PB promotion.These results are strongly suggestive of an involvement of phospholipaseA2 lipoxygenase and cyclooxygenase arachidonic acid metabolicpathways in the mechanisms underlying PB enhancement of hepatocarcinogenesis. 相似文献
29.
T. Sakumoto M. Tohyama K. Satoh Y. Kimoto T. Kinugasa O. Tanizawa K. Kurachi N. Shimizu 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1978,31(1):81-94
Summary Attempts were made to determine the afferent projections to the anterior hypothalamus including the preoptic area from the lower brain stem by means of the horseradish peroxidase method combined with monoamine oxidase staining to identify noradrenaline (NA) neurons. In addition to this technique, a histofluorescence analysis was performed. NA fibers in the medial part of the anterior hypothalamus were mainly supplied by A1 and A2 NA neuron groups, while the lateral part and periventricular zone received NA terminals from both pontine and medulla oblongata NA neuron groups. Furthermore, the present study indicated that there were direct projections to the anterior hypothalamus from non-noradrenergic neurons in the lower brain stem: nuclei raphe dorsalis, centralis superior, cells in the mesencephalic and pontine central gray matter, nuclei parabrachialis lateralis and medialis, cells around fasciculus longitudinalis medialis.Abbreviations CA
Commissura anterior
- CO
Chiasma opticum
- DP
Decussatio pyramidum
- DPCS
Decussatio pedunculorum cerebellarium superiorum
- F
Columna fornicis
- FLM
Fasciculus longitudinalis medialis
- FMT
Fasciculus mamillothalamicus
- GCM
Griseum centrale mesencephali
- GCP
Griseum centrale pontis
- LL
Lemniscus lateralis
- LM
Lemniscus medialis
- PCM
Pedunculus cerebellaris medius
- PCS
Pedunculus cerebellaris superior
- TO
Tractus opticus
- TS
Tractus solitarius
- TVme
Tractus mesencephalicus nervi trigemini
- V
Ventriculus tertius
- VTS
Tractus spinalis nervi trigemini
- am
nucleus ambiguus
- B
Barrington nucleus
- com
nucleus commissuralis
- cp
nucleus caudatus putamen
- cs
nucleus centralis superior
- ct
nucleus corporis trapezoidei
- cu
nucleus cuneatus
- dX
nucleus dorsalis nervi vagi
- Gd
nucleus tegmentalis dorsalis (von Gudden)
- gr
nucleus gracilis
- Gv
nucleus tegmentalis ventralis (von Gudden)
- ha
nucleus hypothalamicus anterior
- hl
nucleus hypothalamicus lateralis
- hpe
nucleus periventricularis (hypothalami)
- hvm
nucleus ventromedialis hypothalami
- lc
nucleus locus coeruleus
- oi
nucleus olivaris inferior
- p
nucleus pontis
- pa
nucleus paraventricularis
- pbl
nucleus parabrachialis lateralis
- pbm
nucleus parabrachialis medialis
- ph
nucleus praepositus hypoglossi
- pol
nucleus preopticus lateralis
- pom
nucleus preopticus medialis
- pop
nucleus preopticus periventricularis
- rd
nucleus raphe dorsalis
- re
nucleus reuniens
- rl
nucleus reticularis lateralis
- rm
nucleus raphe magnus
- ro
nucleus raphe obscrus
- sc
nucleus suprachiasmaticus
- so
nucleus supraopticus
- st
nucleus interstitialis striae terminalis
- td
nucleus tractus diagonalis (Broca)
- ts
nucleus tractus solitarii
- Vme
nucleus mesencephalicus nervi trigemini
- Vmo
nucleus motorius nervi trigemini
- Vts
nucleus tractus spinalis nervi trigemini
- XII
nucleus nervi hypoglossi 相似文献
30.
Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia 总被引:3,自引:0,他引:3
Taketomi T Yoshiga D Taniguchi K Kobayashi T Nonami A Kato R Sasaki M Sasaki A Ishibashi H Moriyama M Nakamura K Nishimura J Yoshimura A 《Nature neuroscience》2005,8(7):855-857
We report here that loss of the Sprouty2 gene (also known as Spry2) in mice resulted in enteric nerve hyperplasia, which led to esophageal achalasia and intestinal pseudo-obstruction. Glial cell line-derived neurotrophic factor (GDNF) induced hyperactivation of ERK and Akt in enteric nerve cells. Anti-GDNF antibody administration corrected nerve hyperplasia in Sprouty2-deficient mice. We show Sprouty2 to be a negative regulator of GDNF for the neonatal development or survival of enteric nerve cells. 相似文献