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Aitziber Elvira Urdampilleta Miren Arrue GabilondoBorja Rivero Torrejón Enrique RuizAmaia Oyarzabal Urkiola Arantzazu Murgiondo de SarachoMaría Belar 《Progresos de Obstetricia y Ginecología》2009
Uterine smooth-muscle tumors are not easy to classify. We report a case of uterine smooth-muscle tumor of uncertain malignant potential, which metastasized to retroperitoneal leiomyosarcoma in the left obturator cavity. 相似文献
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Aitziber Elvira Urdampilleta Amaia Oyarzabal UrkiolaJosé Ramón Cortaberria Ibarluzea Iurdana Aizpitarte GorrotxategiBorja Rivero Torrejón 《Progresos de Obstetricia y Ginecología》2009
We report two cases of uterine papillary serous carcinoma in endometrial polyps, which were diagnosed and treated in Donostia Hospital in San Sebastián, Spain. Although the tumors were classified as early stage, both patients suffered disease relapse and progression. 相似文献
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Jose L. Del Pozo Marta Alonso Alicia Serrera Silvia Hernaez Aitziber Aguinaga Jose Leiva 《Diagnostic microbiology and infectious disease》2009
Objective
The purpose of this study is to evaluate the efficacy of antibiotic lock therapy to treat port-related enterococci, Gram-negative, or Gram-positive bacilli bloodstream infections.Patients and Methods
We conducted a prospective observational study including all patients with port-related bacteremia diagnosed at the Clinica Universitaria de Navarra, Pamplona, Spain. During a 36-month period, 110 patients were diagnosed with port-related bacteremia. Of these patients, 18 met criteria to be enrolled in the study. They were treated with a combination of systemic and antibiotic lock therapy (12–24 h/day during 7–14 days). Treatment effectiveness was assessed by clinical and microbiologic criteria.Results
Treatment was associated with clinical and microbiologic success in 88.8% of our patients (2/2 of the Propionibacterium acnes, 5/5 of the Corynebacterium spp., 6/7 of the Gram-negative bacillus, and 3/4 of the Enterococcus faecium port-related bloodstream infections). Mean increase of port life span for all patients after bacteremia was 288 days (range, 0–1403 days).Conclusion
Antibiotic lock therapy combined with systemic antibiotics appears to be a safe and effective treatment of port-related bacteremia caused by enterococci, Gram-negative, or Gram-positive bacilli if the patient is stable and no septic syndrome is associated. 相似文献56.
Leticia Fernández-Friera Valentín Fuster Beatriz López-Melgar Belén Oliva Javier Sánchez-González Angel Macías Braulio Pérez-Asenjo Daniel Zamudio Juan C. Alonso-Farto Samuel España José Mendiguren Héctor Bueno Jose M. García-Ruiz Borja Ibañez Antonio Fernández-Ortiz Javier Sanz 《Journal of the American College of Cardiology》2019,73(12):1371-1382
Background
Atherosclerosis is a chronic inflammatory disease, but data on arterial inflammation at early stages is limited.Objectives
The purpose of this study was to characterize vascular inflammation by hybrid 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/magnetic resonance imaging (PET/MRI).Methods
Carotid, aortic, and ilio-femoral 18F-FDG PET/MRI was performed in 755 individuals (age 40 to 54 years; 83.7% men) with known plaques detected by 2-/3-dimensional vascular ultrasound and/or coronary calcification in the PESA (Progression of Early Subclinical Atherosclerosis) study. The authors evaluated the presence, distribution, and number of arterial inflammatory foci (increased 18F-FDG uptake) and plaques with or without inflammation (coincident 18F-FDG uptake).Results
Arterial inflammation was present in 48.2% of individuals (24.4% femorals, 19.3% aorta, 15.8% carotids, and 9.3% iliacs) and plaques in 90.1% (73.9% femorals, 55.8% iliacs, and 53.1% carotids). 18F-FDG arterial uptakes and plaques significantly increased with cardiovascular risk factors (p < 0.01). Coincident 18F-FDG uptakes were present in 287 of 2,605 (11%) plaques, and most uptakes were detected in plaque-free arterial segments (459 of 746; 61.5%). Plaque burden, defined by plaque presence, number, and volume, was significantly higher in individuals with arterial inflammation than in those without (p < 0.01). The number of plaques and 18F-FDG uptakes showed a positive albeit weak correlation (r = 0.25; p < 0.001).Conclusions
Arterial inflammation is highly prevalent in middle-aged individuals with known subclinical atherosclerosis. Large-scale multiterritorial PET/MRI allows characterization of atherosclerosis-related arterial inflammation and demonstrates 18F-FDG uptake in plaque-free arterial segments and, less frequently, within plaques. These findings suggest an arterial inflammatory state at early stages of atherosclerosis. (Progression of Early Subclinical Atherosclerosis [PESA]; NCT01410318) 相似文献57.
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Susanne Kossatz Julia Grandke Pierre Couleaud Alfonso Latorre Antonio Aires Kieran Crosbie-Staunton Robert Ludwig Heidi D?hring Volker Ettelt Ana Lazaro-Carrillo Macarena Calero Maha Sader José Courty Yuri Volkov Adriele Prina-Mello Angeles Villanueva álvaro Somoza Aitziber L Cortajarena Rodolfo Miranda Ingrid Hilger 《Breast cancer research : BCR》2015,17(1)
Introduction
Tumor cells can effectively be killed by heat, e.g. by using magnetic hyperthermia. The main challenge in the field, however, is the generation of therapeutic temperatures selectively in the whole tumor region. We aimed to improve magnetic hyperthermia of breast cancer by using innovative nanoparticles which display a high heating potential and are functionalized with a cell internalization and a chemotherapeutic agent to increase cell death.Methods
The superparamagnetic iron oxide nanoparticles (MF66) were electrostatically functionalized with either Nucant multivalent pseudopeptide (N6L; MF66-N6L), doxorubicin (DOX; MF66-DOX) or both (MF66-N6LDOX). Their cytotoxic potential was assessed in a breast adenocarcinoma cell line MDA-MB-231. Therapeutic efficacy was analyzed on subcutaneous MDA-MB-231 tumor bearing female athymic nude mice.Results
All nanoparticle variants showed an excellent heating potential around 500 W/g Fe in the alternating magnetic field (AMF, conditions: H = 15.4 kA/m, f = 435 kHz). We could show a gradual inter- and intracellular release of the ligands, and nanoparticle uptake in cells was increased by the N6L functionalization. MF66-DOX and MF66-N6LDOX in combination with hyperthermia were more cytotoxic to breast cancer cells than the respective free ligands. We observed a substantial tumor growth inhibition (to 40% of the initial tumor volume, complete tumor regression in many cases) after intratumoral injection of the nanoparticles in vivo. The proliferative activity of the remaining tumor tissue was distinctly reduced.Conclusion
The therapeutic effects of breast cancer magnetic hyperthermia could be strongly enhanced by the combination of MF66 functionalized with N6L and DOX and magnetic hyperthermia. Our approach combines two ways of tumor cell killing (magnetic hyperthermia and chemotherapy) and represents a straightforward strategy for translation into the clinical practice when injecting nanoparticles intratumorally.Electronic supplementary material
The online version of this article (doi:10.1186/s13058-015-0576-1) contains supplementary material, which is available to authorized users. 相似文献60.
Silvia Locarno Aitziber Eleta-Lopez Maria Giovanna Lupo Maria Luisa Gelmi Francesca Clerici Alexander M. Bittner 《RSC advances》2019,9(36):20565
We investigate the electrospinning of small molecules, specifically designed peptide derivatives of the pyrazole-isothiazole scaffold. Such non-natural peptides enhance the spectrum of fundamental materials used for electrospinning. Unlike standard electrospun materials, our peptides are not polymeric, but able to aggregate in solution and especially during processing. They contain donor/acceptor groups that can form hydrogen bonds, and groups that are able to generate π-stacking interactions, which are known as important requirements for assembly processes. The pyrazole-isothiazole derivatives were synthesized by means of a 1,3-dipolar cycloaddition reaction, which is completely regioselective, affording only one isomer. We demonstrate that our compounds can be electrospun from fluoroalcohol solution into solid, quasi-endless micro- and nanofibers. The electrospinnability varies substantially, depending on the amino acids linked to the scaffold. Some compounds provide only short fibers, while Fmoc-glycyl-(N-benzyl)-pyrazole-isothiazole-tert-butyl carboxylate-1,1-dioxide forms continuous, homogenous, and bead-free fibers (droplet-like beads are a common problem in electrospinning). We analyzed the compounds and the fibers with various spectroscopic techniques (MS, IR and Raman). Electrospinning does not change chemical composition and configuration, suggesting the monomeric form of the compounds even in the fibers. Interestingly, we found that the stereochemistry of the scaffold can affect the ability of the peptide to be electrospun.Pyrazole-isothiazole monomers are electrospun from solution into solid, quasi-endless micro- and nanofibers. 相似文献