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981.
Maria Luz Gonzalez-Gadea Sandra Baez Teresa Torralva Francisco Xavier Castellanos Alexia Rattazzi Victoria Bein Katharina Rogg Facundo Manes Agustin Ibanez 《Research in developmental disabilities》2013,34(2):817-830
Attention-deficit/hyperactivity disorder (ADHD) and Asperger's Syndrome (AS) share a heterogeneous cognitive profile. Studies assessing executive functions (EF) and social cognition in both groups have found preserved and impaired performances. These inconsistent findings would be partially explained by the cognitive variability reported in these disorders. First, the present study explored the inter-individual variability in EF and social cognition in both patient groups. Second, we compared differential characteristics and commonalities in the cognitive profiles of EF and social cognition between ADHD, AS and control adults. We assessed 22 patients with ADHD, 23 adults with AS and 21 matched typically developing subjects using different measures of EF (working memory, cognitive flexibility and multitasking) and social cognition (theory of mind and decision-making). Group comparisons and multiple case series analyses (MCSA) were conducted. The between-group comparisons showed an EF deficit in working memory in ADHD and a theory of mind (ToM) impairment in AS. The MCSA evidenced that, compared to controls, ADHD patients had a higher inter-individual variability in EF, while individuals with AS had a more heterogeneous profile in social cognition tasks compared to both groups. Finally, the AS and ADHD groups presented higher task-related variability compared to controls and shared a common heterogeneous profile in EF. This is the first study to compare variability in EF and social cognition profiles of ADHD and AS. We propose that heterogeneity in EF performance is a link between ADHD and AS which may explain the overlap of symptomatology between both diagnoses. In addition, patients with AS seem to show a unique heterogeneous profile in ToM which may explain the low probability of finding AS symptoms in patients with ADHD. 相似文献
982.
983.
Yaping Liu MD PhD Michael A. Lawton MPhil Christine Lo DPhil MRCP Francesca Bowring M.Sc Johannes C. Klein MD PhD Agustin Querejeta-Coma MD Sangeeta Scotton MBBS MRCP Jessica Welch M.Sc Jamil Razzaque M.Sc Thomas Barber DPhil MRCP Yoav Ben-Shlomo PhD MRCP Michele T. Hu PhD FRCP 《Movement disorders》2021,36(12):2821-2832
984.
Marcia Janneth Bermeo Cabrera Pablo Roberto Ordoez Chacha Alfredo Adolfo RezaAlbarrn Ana Karina Ordoez Chacha Marcy Acosta Acero Agustin Rodas Serrano 《Clinical Case Reports》2022,10(8)
X‐linked hypophosphatemia (XLH) is a rare disexase in which patients present with severe bowing of the legs, joint pain, and mobility problems. XLH has major adverse repercussions on the quality of life. 相似文献
985.
Dennis Deafen Agustin Escalante Lisa Weinrib David Horwitz Barbara Bachman Pradip Roy-Burman Ann Walker Thomas M. Mack 《Arthritis \u0026amp; Rheumatology》1992,35(3):311-318
Objective. Based on a small clinical series and previously published case reports, concordance for systemic lupus erythematosus (SLE) among monozygous (MZ) twins has been reported to be as high as 69%. Using a larger and less biased sample, we provide another estimate of this percentage. Methods. We established a registry of twins with SLE, based upon self-reports and information provided by the patients' physicians. We used DNA fingerprinting to validate the reported zygosity in a sample of these twins. Results. Of 107 twin pairs meeting the American College of Rheumatology 1982 revised criteria for the diagnosis of SLE, 24% of 45 MZ pairs and 2% of 62 dizygous (DZ) pairs were concordant. The frequency distributions of diagnostic criteria and disease symptoms in the SLE patients were similar to those in other published reports of SLE patients. Zygosity was confirmed by DNA fingerprinting in a subsample of 15 self-described MZ twins and 7 self-described DZ twins. AH individuals had correctly predicted their zygosity. Conclusion. MZ concordance for SLE is similar to that for other autoimmune diseases and is much lower than previously believed. 相似文献