全文获取类型
收费全文 | 4520篇 |
免费 | 205篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 105篇 |
儿科学 | 196篇 |
妇产科学 | 216篇 |
基础医学 | 691篇 |
口腔科学 | 33篇 |
临床医学 | 280篇 |
内科学 | 1000篇 |
皮肤病学 | 71篇 |
神经病学 | 423篇 |
特种医学 | 76篇 |
外科学 | 221篇 |
综合类 | 28篇 |
预防医学 | 375篇 |
眼科学 | 120篇 |
药学 | 594篇 |
中国医学 | 13篇 |
肿瘤学 | 297篇 |
出版年
2024年 | 2篇 |
2023年 | 24篇 |
2022年 | 157篇 |
2021年 | 305篇 |
2020年 | 105篇 |
2019年 | 138篇 |
2018年 | 148篇 |
2017年 | 129篇 |
2016年 | 157篇 |
2015年 | 159篇 |
2014年 | 201篇 |
2013年 | 294篇 |
2012年 | 368篇 |
2011年 | 380篇 |
2010年 | 201篇 |
2009年 | 151篇 |
2008年 | 239篇 |
2007年 | 312篇 |
2006年 | 280篇 |
2005年 | 266篇 |
2004年 | 197篇 |
2003年 | 196篇 |
2002年 | 155篇 |
2001年 | 19篇 |
2000年 | 16篇 |
1999年 | 14篇 |
1998年 | 7篇 |
1997年 | 12篇 |
1996年 | 10篇 |
1995年 | 6篇 |
1992年 | 7篇 |
1991年 | 4篇 |
1990年 | 7篇 |
1989年 | 6篇 |
1988年 | 8篇 |
1987年 | 5篇 |
1986年 | 6篇 |
1984年 | 2篇 |
1983年 | 8篇 |
1982年 | 5篇 |
1981年 | 2篇 |
1979年 | 3篇 |
1978年 | 7篇 |
1977年 | 5篇 |
1976年 | 2篇 |
1975年 | 3篇 |
1974年 | 6篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有4739条查询结果,搜索用时 31 毫秒
91.
Ecotoxicological characteristics and ecological risk assessment of trace elements in the bottom sediments of the Rożnów reservoir (Poland) 总被引:1,自引:0,他引:1
Szara Magdalena Baran Agnieszka Klimkowicz-Pawlas Agnieszka Tarnawski Marek 《Ecotoxicology (London, England)》2020,29(1):45-57
Ecotoxicology - The bottom sediments in catchment areas behind dams play a significant role in water ecosystems. On the other hand, the structure of sediments makes them a natural geosorbent, in... 相似文献
92.
Izabela Szczygielska El?bieta Hernik Ma?gorzata Kwiatkowska Lidia Rutkowska-Sak Beata Ko?odziejczyk Agnieszka Gazda 《Reumatologia》2015,53(2):56-60
Objectives
Protective vaccinations are the most effective method of prevention of type B virus hepatitis. The aim of the study was to determine whether in children receiving immunosuppressive therapy due to inflammatory systemic connective tissue diseases the protective concentration of the anti-HBs antibodies produced after vaccination against type B virus hepatitis in infancy is maintained.Material and methods
The concentration of anti-HBs antibodies was assessed in the sera of 50 children with inflammatory connective tissue diseases – 37 girls (74%) and 13 boys (26%), aged 1.5–17.5 years – during the immunosuppressive treatment, which lasted at least 6 months. The control group consisted of 50 healthy children – 28 girls (56%) and 22 boys (44%) aged 2–17 years. All children were vaccinated in infancy with Engerix B vaccine according to the 0–1–6 months schedule. The antibody concentration of ≥ 10 mIU/ml in patients is regarded as protective.Results
No protective antibody concentrations were found in 25 cases (50%) in the group of diseased children and only in 2 children in the control group (4%).Conclusions
The concentration of vaccine-induced antibodies should be assessed in children with inflammatory systemic connective tissue diseases and, in case of the absence of a protective concentration, revaccination should be started. The use of glucocorticosteroids, synthetic and biological disease-modifying antirheumatic drugs is no contraindication to vaccination against hepatitis B. 相似文献93.
Longitudinal variations of laryngeal overpressure and voice‐related quality of life in spasmodic dysphonia
下载免费PDF全文
![点击此处可从《The Laryngoscope》网站下载免费的PDF全文](/ch/ext_images/free.gif)
94.
Genotype-phenotype assessment of common genotypes among patients with familial Mediterranean fever 总被引:2,自引:0,他引:2
Shinar Y Livneh A Langevitz P Zaks N Aksentijevich I Koziol DE Kastner DL Pras M Pras E 《The Journal of rheumatology》2000,27(7):1703-1707
OBJECTIVE: To study genotype-phenotype correlation for the 4 most common genotypes found among patients with familial Mediterranean fever (FMF). METHODS: Thirty patients with the M694V/M694V genotype, 32 with M694V/V726A genotype, 25 with M694V/E 148Q genotype, and 21 with V726A/V726A genotype were assessed for various clinical manifestations of FMF, and overall disease severity. RESULTS: Patients with the M694V/M694V genotype were found to have an earlier age of onset, higher frequency of joint involvement, higher frequency of erysipelas-like erythema, and required higher doses of colchicine to control the disease compared to the other 3 genotypes. CONCLUSION: The M694V/M694V genotype is associated with more severe disease compared to other common genotypes in patients with FMF. 相似文献
95.
Agnieszka Szypowska Lidia Groele Marta Wysocka-Mincewicz Artur Mazur Lucyna Lisowicz Iwona Ben-Skowronek Joanna Sieniawska Bożenna Klonowska Dorota Charemska Jolanta Nawrotek Irena Jałowiec Artur Bossowski Klaudyna Noiszewska Beata Pyrżak Izabela Rogozińska Mieczysław Szalecki 《Journal of diabetes and its complications》2018,32(6):570-574
Aims
The level of C-peptide can identify individuals most likely to respond to immune interventions carried out to prevent pancreatic β-cell damage.The aim of the study was to evaluate factors associated with C-peptide levels at type 1 diabetes (T1D) diagnosis.Methods
This study included 1098 children aged 2-17 with newly recognized T1D. Data were collected from seven Polish hospitals. The following variables were analyzed: date of birth, fasting C-peptide, HbA1c, sex, weight, height, pH at diabetes onset.Results
A correlation was observed between fasting C-peptide level and BMI-SDS (p?=?0.0001), age (p?=?0.0001), and HbA1c (p?=?0.0001). The logistic regression model revealed that fasting C-peptide ≥0.7 ng/ml at diabetes diagnosis was dependent on weight, HbA1c, pH and sex (p?<?0.0001).Overweight and obese children (n?=?124) had higher fasting C-peptide (p?=?0.0001) and lower HbA1c (p?=?0.0008) levels than other subjects. Girls had higher fasting C-peptide (p?=?0.036) and higher HbA1c (p?=?0.026) levels than boys.Conclusion
Obese and overweight children are diagnosed with diabetes at an early stage with largely preserved C-peptide levels. Increased awareness of T1D symptoms as well as improved screening and diagnostic tools are important to preserve C-peptide levels. There are noticeable gender differences in the course of diabetes already at T1D diagnosis. 相似文献96.
C-reactive protein as a marker of heart failure 总被引:1,自引:0,他引:1
Nessler J Nessler B Piwowarska W Skrzypek A Kitliński M Stepniewski M 《Acta cardiologica》2004,59(2):217-218
97.
Sandeep K. Mallipattu Sylvia J. Horne Vivette D’Agati Goutham Narla Ruijie Liu Michael A. Frohman Kathleen Dickman Edward Y. Chen Avi Ma’ayan Agnieszka B. Bialkowska Amr M. Ghaleb Mandayam O. Nandan Mukesh K. Jain Ilse Daehn Peter Y. Chuang Vincent W. Yang John C. He 《The Journal of clinical investigation》2015,125(3):1347-1361
98.
Jamese J. Hilliard Vivekananda Datta Christine Tkaczyk Melissa Hamilton Agnieszka Sadowska Omari Jones-Nelson Terrence O'Day William J. Weiss Szabolcs Szarka Vien Nguyen Laszlo Prokai JoAnn Suzich C. Kendall Stover Bret R. Sellman 《Antimicrobial agents and chemotherapy》2015,59(1):299-309
Alpha-toxin (AT) is a major virulence determinant in Staphylococcus aureus skin and soft tissue infection models. We previously demonstrated that prophylactic administration of 2A3, an AT-neutralizing monoclonal antibody (MAb), prevents S. aureus disease in a mouse dermonecrosis model by neutralizing AT-mediated tissue necrosis and immune evasion. In the present study, MEDI4893*, an affinity-optimized version of 2A3, was characterized for therapeutic activity in the dermonecrosis model as a single agent and in combination with two frontline antibiotics, vancomycin and linezolid. MEDI4893* postinfection therapy was found to exhibit a therapeutic treatment window similar to that for linezolid but longer than that for vancomycin. Additionally, when combined with either vancomycin or linezolid, MEDI4893* resulted in reduced tissue damage, increased neutrophil and macrophage infiltration and abscess formation, and accelerated healing relative to those with the antibiotic monotherapies. These data suggest that AT neutralization with a potent MAb holds promise for both prophylaxis and adjunctive therapy with antibiotics and may be a valuable addition to currently available options for the treatment of S. aureus skin and soft tissue infections. 相似文献
99.
Jacek Polechoński W?adys?aw Mynarski Agnieszka Nawrocka 《Journal of Physical Therapy Science》2015,27(11):3525-3527
[Purpose] The objective of this study was to evaluate the usefulness of pedometry and
accelerometry in the measurement of the energy expenditures in Nordic walking and
conventional walking as diagnostic parameters. [Subjects and Methods] The study included
20 female students (age, 24 ± 2.3 years). The study used three types of measuring devices,
namely a heart rate monitor (Polar S610i), a Caltrac accelerometer, and a pedometer (Yamax
SW-800). The walking pace at the level of 110 steps/min was determined by using a
metronome. [Results] The students who walked with poles covered a distance of 1,000 m at a
speed 36.3 sec faster and with 65.5 fewer steps than in conventional walking. Correlation
analysis revealed a moderate interrelationship between the results obtained with a
pedometer and those obtained with an accelerometer during Nordic walking
(r = 0.55) and a high correlation during conventional walking
(r = 0.85). [Conclusion] A pedometer and Caltrac accelerometer should
not be used as alternative measurement instruments in the comparison of energy expenditure
in Nordic walking.Key words: Nordic walking, Accelerometer, Energy expenditure 相似文献
100.