全文获取类型
收费全文 | 287744篇 |
免费 | 13374篇 |
国内免费 | 598篇 |
专业分类
耳鼻咽喉 | 3722篇 |
儿科学 | 8921篇 |
妇产科学 | 6270篇 |
基础医学 | 40880篇 |
口腔科学 | 6449篇 |
临床医学 | 22715篇 |
内科学 | 64036篇 |
皮肤病学 | 7414篇 |
神经病学 | 25893篇 |
特种医学 | 9028篇 |
外国民族医学 | 131篇 |
外科学 | 35868篇 |
综合类 | 1285篇 |
一般理论 | 73篇 |
预防医学 | 26033篇 |
眼科学 | 5443篇 |
药学 | 19953篇 |
中国医学 | 843篇 |
肿瘤学 | 16759篇 |
出版年
2023年 | 1489篇 |
2022年 | 1669篇 |
2021年 | 4948篇 |
2020年 | 2801篇 |
2019年 | 5085篇 |
2018年 | 10006篇 |
2017年 | 6491篇 |
2016年 | 5970篇 |
2015年 | 6500篇 |
2014年 | 7342篇 |
2013年 | 11474篇 |
2012年 | 18907篇 |
2011年 | 18987篇 |
2010年 | 9777篇 |
2009年 | 7718篇 |
2008年 | 16333篇 |
2007年 | 17300篇 |
2006年 | 16042篇 |
2005年 | 15922篇 |
2004年 | 14952篇 |
2003年 | 13808篇 |
2002年 | 13059篇 |
2001年 | 7588篇 |
2000年 | 7774篇 |
1999年 | 6804篇 |
1998年 | 1429篇 |
1997年 | 1104篇 |
1996年 | 1035篇 |
1995年 | 958篇 |
1992年 | 3922篇 |
1991年 | 3497篇 |
1990年 | 3380篇 |
1989年 | 3094篇 |
1988年 | 2855篇 |
1987年 | 2720篇 |
1986年 | 2536篇 |
1985年 | 2321篇 |
1984年 | 1711篇 |
1983年 | 1434篇 |
1979年 | 1450篇 |
1978年 | 1014篇 |
1977年 | 950篇 |
1975年 | 955篇 |
1974年 | 1172篇 |
1973年 | 1189篇 |
1972年 | 1118篇 |
1971年 | 1106篇 |
1970年 | 1016篇 |
1969年 | 1075篇 |
1968年 | 959篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
Lipid peroxidation, occupational stress and aging in workers of a prehospital emergency service. 总被引:2,自引:0,他引:2
Angela Casado Nieves De Lucas Encarnación López-Fernández Alberto Sánchez José-Antonio Jimenez 《European journal of emergency medicine》2006,13(3):165-171
BACKGROUND: Stressful conditions lead to formation of excessive free radicals, and lipid peroxidation is one of the major outcomes of free radical-mediated injury that directly damages membranes and generates a number of secondary products. OBJECTIVES: To determine the levels of malondialdehyde, an end product of lipid peroxidation, according to demographic and occupational variables in workers of a prehospital emergency service and to analyse the relationship between malondialdehyde levels and burnout. MATERIAL AND METHODS: One hundred and eleven healthy workers of a prehospital emergency service and eighty aged-matched healthy individuals of both sexes as a control group were surveyed. Malondialdehyde levels were measured by the Bull and Marnett method. To measure burnout, the Maslach Burnout Inventory was used. RESULTS: Professional category is associated with lipid peroxidation and burnout levels (Malondialdehyde levels were: physicians 338.10+/-14.47, nurses 329.17+/-12.62 and technicians 296.74+/-14.28; burnout levels were: physicians 41.29+/-3.59, nurses 37.38+/-6.05 and technicians 35.33+/-5.87). Working at night and in the evening increased malondialdehyde and burnout levels. Malondialdehyde levels increase with age. No significant variations with respect to sex were detected. Significant variations in malondialdehyde levels were detected between singles (303.13+/-12.74) and married people (344.43+/-13.43) but not with respect to divorcees (326.44+/-11.74). Significant differences were detected in erythrocyte malondialdehyde levels between smokers (341.37+/-17.09) and nonsmokers (302.21+/-12.38), but not for alcohol consumption. CONCLUSIONS: These findings suggest a positive correlation between malondialdehyde, a biomarker of lipid peroxidation and occupational stress, as estimated by elements of the Maslach Burnout Inventory, and oxidative stress. 相似文献
92.
93.
94.
Victor Aboyans Louis Labrousse Philippe Lacroix Jér?me Guilloux Seifeddine Sekkal Alexandre Le Guyader Elisabeth Cornu Marc Laskar 《European journal of cardio-thoracic surgery》2006,30(2):300-304
BACKGROUND: Despite major improvement in surgical techniques and intensive care management, stroke remains one of the most devastating complications of coronary artery bypass grafting (CABG). We aimed to determine factors predicting the occurrence of stroke during CABG. A special interest was focused on preoperative therapies. METHODS: We prospectively enrolled 810 consecutive candidates for CABG alone in a specific database, including all pre- and perioperative data (history, clinical, therapeutic, cardiac catheterization, surgical and intensive care data). Univariate tests and then multiple logistic regression analysis were used to determine independent predictive factors. RESULTS: During the first postoperative month, stroke occurred in 11 cases and transient ischemic attack (TIA) in 4 additive cases (cumulative rate: 1.85%). After the multivariate analysis, the following factors remained significant (p<0.05) in the predictive model, with corresponding odds ratios between brackets: redo cardiac surgery (7.45), unstable cardiac status (4.74), past history of cerebrovascular disease (4.14), past history of peripheral arterial disease (3.55), whereas the presence of preoperative statins was protective (0.24, 95% IC: 0.07-0.78). The addition of perioperative data (aortic calcification, postoperative arrhythmia, on/off-pump surgery) did not change the final predictive model. CONCLUSION: To our knowledge, this is the first real-world observational report highlighting the interest of statins for the prevention of stroke in the very special situation of CABG. Even though according to randomized trials coronary patients have a benefit from these drugs, a special level of interest should be directed towards those presenting the above-mentioned risk factors. 相似文献
95.
96.
97.
Jean-Sébastien Fallu Jürgen Rehm Emmanuel N. Kuntsche Esther Grichting Neerav Monga Edward M. Adlaf Susan J Bondy Gerhard Gmel 《Sozial- und Pr?ventivmedizin》2006,8(1):363-372
Volume and profile of alcohol consumption among students and classmates as predictors of aggression and victimization: a multilevel
analysis among Swiss adolescents
Objective:
To test the effects of the volume of alcohol consumption and drinking patterns on alcohol-related aggression and victimization, both at the individual and class levels. 相似文献98.
Jér?me Dumortier Marie-Claude Gagnieu Janine Salandre Olivier Guillaud Philipe Guillem Mustapha Adham Olivier Boillot 《Liver transplantation》2006,12(9):1342-1346
Gastrointestinal (GI) disorders are one of the main adverse events in patients treated by mycophenolic acid (MPA). The aim of this prospective study was to evaluate the effect of conversion from mycophenolate mofetil (MMF) to enteric-coated mycophenolate sodium (EC-MPS) in liver transplant patients presenting GI side-effects Since January 2003, stable liver transplant patients receiving MMF and presenting GI disorders, without evidence of other origin than MMF were enrolled. Conversion was performed without a washout period at an equimolar daily dosage. Thirty-six patients were included after a median delay of 45 months after liver transplantation (LT) (16 women and 20 men, median age of 47 years). Diarrhoea was the main clinical symptom (n = 28, 77.7%). At the time of inclusion, patients were treated with MMF since 18 months (range 3-28) and GI disorders were known for 9 months (range 3-12). After a median follow-up of 12 months after conversion, GI disorders were resolved in 20 patients (55%), improved in 6 patients (17%) and not modified or worsened in 10 patients (28%). Our results strongly suggest that conversion from MMF to EC-MPS in liver transplant patients can improve gastrointestinal disorders in a majority of the patients, and therefore might be considered as the best therapeutic option. 相似文献
99.
L González-Bayón S González-Moreno G Ortega-Pérez 《European journal of surgical oncology》2006,32(6):619-624
The new treatment strategy for Peritoneal Surface Malignancy combines a cytoreductive surgery and perioperative intraperitoneal chemotherapy. Cytoreduction removes all macroscopic tumor. Intraperitoneal chemotherapy avoids implantation of microscopic residual tumor cells on intra-abdominal surfaces when it is administered intraoperatively and/or early in the postoperative period. Delivering cytotoxic drugs directly into the peritoneal cavity maximizes dose intensity and minimizes systemic toxicity. Hyperthermia is selectively cytotoxic for malignant cells and potentiates the effect of chemotherapy. Implementation of this procedure makes the perioperative personnel to face a risk of exposure to cytotoxic agents. Furthermore, peritonectomies and electro-evaporation of tumor nodules are performed with high voltage electrocautery, generating a large amount of surgical smoke during several hours. Inhalation of these fumes may be also a risk for healthcare workers. In this article, we analyse in depth these new risks of the operating room personnel, we review the literature, and we give guidelines for secure performance of cytoreductive surgery and hyperthermic intraoperative intraperitoneal chemotherapy, as well as for early postoperative intraperitoneal chemotherapy administration. These new procedures are safe techniques for patients and healthcare workers provided adequate policies are adopted to avoid occupational exposure. 相似文献
100.