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排序方式: 共有462条查询结果,搜索用时 15 毫秒
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TAM Kaandorp JJ Bax SE Bleeker J Doornbos EP Viergever D Poldermans EE van der Wall A de Roos HJ Lamb 《Journal of cardiovascular magnetic resonance》2010,12(1):7
Background
To assess the relationship between improved regional and global myocardial function in patients with ischemic cardiomyopathy in response to β-blocker therapy or revascularization.Materials and methods
Cardiovascular Magnetic Resonance (CMR) was performed in 32 patients with ischemic cardiomyopathy before and 8 ± 2 months after therapy. Patients were assigned clinically to β-blocker therapy (n = 20) or revascularization (n = 12). CMR at baseline was performed to assess regional and global LV function at rest and under low-dose dobutamine. Wall thickening was analyzed in dysfunctional, adjacent, and remote segments. Follow-up CMR included rest function evaluation.Results
Augmentation of wall thickening during dobutamine at baseline was similar in dysfunctional, adjacent and remote segments in both patient groups. Therefore, baseline characteristics were similar for both patient groups. In both patient groups resting LV ejection fraction and end-systolic volume improved significantly (p < 0.05) at follow-up. Stepwise multivariate analysis revealed that improvement in global LV ejection fraction in the β-blocker treated patients was significantly related to improved function of remote myocardium (p < 0.05), whereas in the revascularized patients improved function in dysfunctional and adjacent segments was more pronounced (p < 0.05).Conclusion
In patients with chronic ischemic LV dysfunction, β-Blocker therapy or revascularization resulted in a similar improvement of global systolic LV function. However, after β-blocker therapy, improved global systolic function was mainly related to improved contraction of remote myocardium, whereas after revascularization the dysfunctional and adjacent regions contributed predominantly to the improved global systolic function. 相似文献104.
Kathleen F. Benson David M. Ager Bernie Landes Okezie I. Aruoma Gitte S. Jensen 《Preventive medicine》2012
ObjectiveTo evaluate anti-inflammatory properties of a nutraceutical blend containing L-ergothioneine in concert with other anti-inflammatory and analgesic ingredients, combined with nutritional cartilage support.MethodologyTwelve human subjects were tested over a 6-week period of product consumption followed by a 6-week wash-out period, conducted at NIS Labs during late fall/early winter 2010. Range of motion (ROM) assessment of joint motility was performed using JTECH dual digital inclinometry and included flexion, extension, and rotation through the vertical weight-bearing column (neck, thorax, lumbar, hip, knees) and shoulders. Pain evaluation included questionnaires and Visual Analogues Scales regarding primary and secondary pain complaints at rest and at use.ResultsROM improvements were seen after 1 week, and further improved at 6 weeks (primary pain area P < 0.2, secondary pain area P < 0.03). Pain in primary and secondary areas at use was significantly reduced already at 1 week, compared to baseline (P < 0.05). Pain reduction for both primary and secondary pain areas during use reached a high level of statistical significance at 6 weeks (P < 0.004), and remained highly significant after the 6-week wash-out period.ConclusionPain reduction and improved ROM were observed during the 6-week consumption. Residual effects were seen 6 weeks after stopping consumption of the ergothioneine supplement. 相似文献
105.
A mouse mAb, CT-3, recognizes on chicken T cells a complex of three polypeptides, Mr 20,000, 19,000, and 17,000, two of which are N-glycosylated. The CT-3 antibody is mitogenic for chicken T cells, and it coprecipitates two additional polypeptides of Mr 49,000 and 38,000 in lysates of T cell membranes. Ontogeny studies revealed that 5-6 d after thymic influx of hemopoietic stem cells, their thymocyte progeny begin to express the T3/TCR complex. After hatching 1 wk later, the CT-3+ cells begin splenic migration in large numbers. 相似文献
106.
Cerebral vasculitis--recognition, diagnosis and management 总被引:1,自引:0,他引:1
Scolding NJ; Jayne DR; Zajicek JP; Meyer PA; Wraight EP; Lockwood CM 《QJM : monthly journal of the Association of Physicians》1997,90(1):61-73
Cerebral vasculitis is a serious but uncommon condition which presents
considerable difficulties in recognition, diagnosis and treatment. We
studied eight consecutive patients in whom this diagnosis was made. Despite
the great diversity of symptoms and signs, we noted three clinical
patterns: (i) acute or sub-acute encephalopathy, (ii) a picture with some
similarities to multiple sclerosis ('MS-plus'), and (iii) features of a
rapidly progressive space-occupying lesion. The identification of these
patterns may help recognition of cerebral vasculitis. The diagnostic value
of four investigative procedures not previously studied in cerebral
vasculitis was assessed: ophthalmological examination using low-dose
fluorescein angiography with slit-lamp video microscopy of the anterior
segment (abnormal in 4/5 patients); spinal fluid oligoclonal band analysis
(abnormal in 3/6 patients); anti-neutrophil cytoplasmic antibody assay
(abnormal in 3/8 patients); and indium-labelled white-cell cerebral imaging
(positive in only one patient). Treatment was with steroid alone (n = 2) or
steroid with cyclophosphamide (n = 6). Seven patients responded clinically.
相似文献
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109.
The binding of bovine factor XII to kaolin 总被引:7,自引:0,他引:7
Purified bovine factor XII was radiolabeled with iodine-125 and its binding to kaolin studied. Binding was rapid and was not readily reversible upon adding unlabeled factor XII. The optimum pH for binding was in the region of pH 5-7. The isoelectric point of factor XII was pH 5.7. High concentrations of urea or increasing the ionic strength of the medium did not inhibit binding. Polyvalent macromolecules, such as Polybrene and polylysine, were effective inhibitors of factor XII binding to kaolin. Polylysine caused the release of factor XII that had bound to the kaolin surface. 相似文献
110.
Claire B. Ernhart Tom Greene Robert J. Sokol Susan Martier Thomas A. Boyd Joel Ager 《Alcoholism, clinical and experimental research》1995,19(6):1550-1557
A neonatal examination for fetal alcohol syndrome (FAS) should promote the guidance of parents, the planning of remediation for affected children, and the collection of prevalence data. A blinded examination of FAS characteristics conducted as part of a large prospective study of disadvantaged alcohol-exposed infants identified eight neonates who met the published criteria for FAS. These children were followed through the preschool years with a blinded assessment protocol. Seven of these children were found to have no impairment in cognitive and language development, when compared with their peers, and to be of average size. The one child who was mentally and growth retarded at follow-up who had been diagnosed as FAS might not have been diagnosed FAS using clinical criteria (as opposed to blinded research criteria), because his mother provided in-pregnancy reports of only low alcohol intake; she later acknowledged drinking an average of over 21 drinks/week during the pregnancy. The findings are positive in that they provide hope for children who present FAS at birth, although concern with adverse outcomes is certainly not dispelled. In particular, the possibility of later-emerging impairment in more complex tasks is not ruled out. 相似文献