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81.
A multinational observational investigation of illness perceptions and quality of life among patients with a Fontan circulation 下载免费PDF全文
Christina E. Holbein PhD Nicholas D. Fogleman MS Kevin Hommel PhD Silke Apers PhD Jessica Rassart MSc Philip Moons PhD RN Koen Luyckx PhD Maayke A. Sluman MD Junko Enomoto PhD Bengt Johansson MD PhD Hsiao‐Ling Yang PhD RN Mikael Dellborg MD PhD Raghavan Subramanyan MD Jamie L. Jackson PhD Werner Budts MD PhD Adrienne H. Kovacs PhD Stacey Morrison PsyD Martha Tomlin Cnp Kathy Gosney Mssw Alexandra Soufi MD Katrine Eriksen MSc Corina Thomet MSc Malin Berghammer PhD Luis Alday MD Edward Callus PhD Susan M Fernandes PA‐C Maryanne Caruana MD Samuel Menahem MD Stephen C. Cook MD Gwen R. Rempel PhD RN Kamila White PhD Paul Khairy MD PhD Shelby Kutty MD Gruschen Veldtman MBChB Frcp APPROACH‐IS consortium the International Society for Adult Congenital Heart Disease 《Congenital heart disease》2018,13(3):392-400
Objective: First, to compare QOL and illness perceptions between patients with a Fontan circulation and patients with anatomically simple defects (ie, atrial septal defects [ASD] or ventricular
septal defects [VSD]). Second, to explore illness perceptions as a mediator of the association
between congenital heart disease (CHD) diagnosis and QOL.
Design: Cross-sectional observational study.
Setting: Twenty-four cardiology centers from 15 countries across five continents.
Patients: Four hundred thirty-five adult patients with congenital heart disease (177 Fontan and 258 ASD/VSD) ages 18-83 years.
Outcome Measures: QOL and illness perceptions were assessed by the Satisfaction With Life Scale and the Brief Illness Perceptions Questionnaire, respectively.
Results: Patients with a Fontan circulation reported lower QOL (Wald Z = -3.59, p 5 <.001) and more negative perceptions of their CHD (Wald Z = -7.66, p < .001) compared with patients with ASD/VSD. After controlling for demographics, anxiety, depressive symptoms, and New York Heart Association functional class, path analyses revealed a significant mediation model, αβ = 0.15, p = .002, 95% CI = 0.06-0.25, such that CHD diagnosis was indirectly related to QOL through illness perceptions.
Conclusions: The Fontan sample’s more negative perceptions of CHD were likely a reflection of life with a more complex defect. Illness perceptions appear to account for unique differences in QOL between groups of varying CHD complexity. Psychosocial screening and interventions may be important treatment components for patients with CHD, particularly those with Fontan circulations. 相似文献
Design: Cross-sectional observational study.
Setting: Twenty-four cardiology centers from 15 countries across five continents.
Patients: Four hundred thirty-five adult patients with congenital heart disease (177 Fontan and 258 ASD/VSD) ages 18-83 years.
Outcome Measures: QOL and illness perceptions were assessed by the Satisfaction With Life Scale and the Brief Illness Perceptions Questionnaire, respectively.
Results: Patients with a Fontan circulation reported lower QOL (Wald Z = -3.59, p 5 <.001) and more negative perceptions of their CHD (Wald Z = -7.66, p < .001) compared with patients with ASD/VSD. After controlling for demographics, anxiety, depressive symptoms, and New York Heart Association functional class, path analyses revealed a significant mediation model, αβ = 0.15, p = .002, 95% CI = 0.06-0.25, such that CHD diagnosis was indirectly related to QOL through illness perceptions.
Conclusions: The Fontan sample’s more negative perceptions of CHD were likely a reflection of life with a more complex defect. Illness perceptions appear to account for unique differences in QOL between groups of varying CHD complexity. Psychosocial screening and interventions may be important treatment components for patients with CHD, particularly those with Fontan circulations. 相似文献
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厚朴酚抗菌作用的实验观察 总被引:5,自引:0,他引:5
为探讨厚朴酚对口腔致龋菌的抗菌作用、杀菌时间及对双歧杆菌的影响,采用试管法测定了厚朴酚对6种菌的最低杀菌浓度,其中对变链C、g及对青春双歧杆菌的MBC为16μg/ml,对溶血性链球菌和保加利亚乳杆菌的MBC均为4μg/ml;在4倍的MBC浓度下,对变链g的杀菌时间为3分钟。结果提示:厚朴酚长期应用时应注意维护肠道菌群平衡。 相似文献
86.
Comparison of cancer survival trends in the United States of adolescents and young adults with those in children and older adults 下载免费PDF全文
Theresa H.M. Keegan MS PhD Lynn A.G. Ries MS Ronald D. Barr MB ChB MD Ann M. Geiger PhD Deborah Vollmer Dahlke DrPH Bradley H. Pollock MPH PhD W. Archie Bleyer MD for the National Cancer Institute Next Steps for Adolescent Young Adult Oncology Epidemiology Working Group 《Cancer》2016,122(7):1009-1016
87.
Yanada M Takeuchi J Sugiura I Akiyama H Usui N Yagasaki F Nishii K Ueda Y Takeuchi M Miyawaki S Maruta A Narimatsu H Miyazaki Y Ohtake S Jinnai I Matsuo K Naoe T Ohno R;Japan Adult Leukemia Study Group 《Haematologica》2008,93(2):287-290
To identify factors associated with relapse-free survival (RFS), 80 patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia, enrolled in a phase II study of imatinib-combined chemotherapy, were analyzed. The median follow-up of surviving patients was 26.7 months (maximum, 52.5 months). Twenty-eight out of 77 patients who had achieved CR relapsed. The probability of RFS was 50.5% at 2 years. Multivariate analysis revealed that the presence of secondary chromosome aberrations in addition to t(9;22) at diagnosis constitute an independent predictive value for RFS (p=0.027), and increase the risk of treatment failure by 2.8-fold. 相似文献
88.
Mulligan K Zackin R Clark RA Alston-Smith B Liu T Sattler FR Delvers TB Currier JS;AIDS Clinical Trials Group Study Team;National Institute of Allergy Infectious Diseases Adult AIDS Clinical Trials Group 《Archives of internal medicine》2005,165(5):578-585
BACKGROUND: Weight loss is associated with accelerated mortality and disease progression in patients with human immunodeficiency virus (HIV) infection. Although studies have examined a variety of anabolic therapies in HIV-infected men, the safety and efficacy of such treatments in women have not been adequately studied. METHODS: In this randomized, double-blind, placebo-controlled, multicenter, phase I/II study, 38 HIV-infected women with documented weight loss of 5% or greater in the preceding year or a body mass index of less than 20 kg/m(2) were randomized to receive nandrolone decanoate (100 mg) or an equivalent volume of placebo every other week by intramuscular injection. Subjects received blinded treatment for 12 weeks, followed by open-label therapy for 12 weeks. Lean body mass and fat (bioelectrical impedance analysis) and weight were measured at baseline and at weeks 6, 12, 18, and 24. Biochemical assessments of safety (hematologic analyses, liver function tests, and sex hormone measurements) were performed at these same time points. Clinical signs and symptoms were monitored biweekly. RESULTS: Subjects randomized to receive nandrolone had significant increases in weight and lean body mass during blinded treatment (4.6 kg [9.0%] and 3.5 kg [8.6%], respectively; P<.001 vs baseline and placebo in each case). Fat mass did not change statistically significantly in either group. Although there were no statistically significant differences between groups in biochemical measures, the number of grade 3 or greater toxicities, or reports of virilizing effects, a full assessment of safety cannot be made in a trial of this size. CONCLUSION: Nandrolone decanoate therapy may prove to be generally safe and beneficial in reversing weight loss and lean tissue loss in women with HIV infection and other chronic catabolic diseases. 相似文献
89.
Miyawaki S Sakamaki H Ohtake S Emi N Yagasaki F Mitani K Matsuda S Kishimoto Y Miyazaki Y Asou N Matsushima T Takahashi M Ogawa Y Honda S Ohno R;Japan Adult Leukemia Study Group AML Study 《Cancer》2005,104(12):2726-2734
BACKGROUND: A major concern in the treatment of patients with acute myeloid leukemia (AML) is how to prevent disease recurrences. Although intensive consolidation therapy has proven useful, the effectiveness of maintenance therapy remains controversial. METHODS: Seven hundred eighty-nine patients ages 15-64 (median: 45 yrs) with de novo AML received induction therapy, which consisted of cytosine arabinoside (at a dose of 100 mg/m(2) on Days 1-7) and idarubicin (at a dose of 12 mg/m(2) on Days 1-3). The patients who achieved complete remission (CR) were then randomized into groups that received either four courses of standard-dose consolidation therapy without maintenance (Arm A) or three courses of standard-dose consolidation and six courses of maintenance therapy (Arm B). RESULTS: In total, 78.7% of patients achieved CR. The 5-year overall survival (OS) rate for the 789 eligible patients was 46.9%, and the disease-free survival (DFS) rate for the 621 patients who achieved CR was 32.9%. The 5-year OS rate for Arm A was 52.4%, and 58.4% for Arm B (P = 0.599). The 5-year DFS rate for the patients who achieved CR was 35.8% in Arm A and 30.4% in Arm B (P = 0.543). In analyzing the data according to the risk groups, no statistical difference was observed either in the 5-year OS rate or in the 5-year DFS rate between the 2 arms. CONCLUSIONS: In the current study, the Japan Adult Leukemia Study Group's conventional postremission therapy (three courses of standard-dose consolidation and six courses of maintenance therapy) was replaced successfully by a shorter duration of four courses of standard-dose consolidation therapy without the need for additional maintenance therapy. 相似文献
90.
Psychometric performance of the English language six‐item Caring Behaviours Inventory in an acute care context 下载免费PDF全文