收费全文 | 1837篇 |
免费 | 110篇 |
国内免费 | 7篇 |
耳鼻咽喉 | 49篇 |
儿科学 | 78篇 |
妇产科学 | 31篇 |
基础医学 | 292篇 |
口腔科学 | 17篇 |
临床医学 | 158篇 |
内科学 | 265篇 |
皮肤病学 | 263篇 |
神经病学 | 143篇 |
特种医学 | 51篇 |
外国民族医学 | 1篇 |
外科学 | 291篇 |
综合类 | 6篇 |
预防医学 | 73篇 |
眼科学 | 30篇 |
药学 | 99篇 |
中国医学 | 1篇 |
肿瘤学 | 106篇 |
2023年 | 13篇 |
2022年 | 29篇 |
2021年 | 75篇 |
2020年 | 38篇 |
2019年 | 69篇 |
2018年 | 88篇 |
2017年 | 41篇 |
2016年 | 43篇 |
2015年 | 41篇 |
2014年 | 62篇 |
2013年 | 86篇 |
2012年 | 152篇 |
2011年 | 135篇 |
2010年 | 71篇 |
2009年 | 63篇 |
2008年 | 99篇 |
2007年 | 96篇 |
2006年 | 82篇 |
2005年 | 78篇 |
2004年 | 47篇 |
2003年 | 45篇 |
2002年 | 55篇 |
2001年 | 32篇 |
2000年 | 35篇 |
1999年 | 43篇 |
1998年 | 17篇 |
1997年 | 8篇 |
1996年 | 12篇 |
1995年 | 18篇 |
1994年 | 13篇 |
1993年 | 8篇 |
1992年 | 24篇 |
1991年 | 25篇 |
1990年 | 19篇 |
1989年 | 19篇 |
1988年 | 22篇 |
1987年 | 20篇 |
1986年 | 13篇 |
1985年 | 12篇 |
1984年 | 16篇 |
1983年 | 8篇 |
1982年 | 15篇 |
1981年 | 4篇 |
1980年 | 9篇 |
1979年 | 14篇 |
1978年 | 5篇 |
1977年 | 10篇 |
1974年 | 5篇 |
1967年 | 3篇 |
1966年 | 2篇 |
Methods
retrospective monocentric study, data of all the patients followed in our unit between January 1st 1984 and April 2014 with the diagnosis or ReA were analyzed (clinical and biological features, management and outcome), and compared between two periods: from January 1984 to December 1993, and from January 2004 to December 2013.Results
Sixty two patients fulfilling international diagnosis criteria were analyzed. There was no significant difference between the two periods in number of new cases, clinical presentation, biological data or outcome. Changes in therapeutic management were obvious with occurrence of anti TNF in the recent period.Conclusion
Reactive arthritis is still a current rheumatologic problem in a developed country, with a need of early and tailored rheumatologic management. 相似文献Background:
In Alzheimer’s disease, growing evidence has shown that uncontrolled glial activation and neuroinflammation may contribute independently to neurodegeneration. Antiinflammatory strategies might provide benefits for this devastating disease. The aims of the present study are to address the issue of whether glial activation and proinflammatory cytokine increases could be modulated by quetiapine in vivo and in vitro and to explore the underlying mechanism.Methods:
Four-month–old amyloid precursor protein (APP) and presenilin 1 (PS1) transgenic and nontransgenic mice were treated with quetiapine (5mg/kg/d) in drinking water for 8 months. Animal behaviors, total Aβ levels, and glial activation were evaluated by behavioral tests, enzyme-linked immunosorbent assay, immunohistochemistry, and Western blot accordingly. Inflammatory cytokines and the nuclear factor kappa B pathway were analyzed in vivo and in vitro.Results:
Quetiapine improves behavioral performance, marginally affects total Aβ40 and Aβ42 levels, attenuates glial activation, and reduces proinflammatory cytokines in APP/PS1 mice. Quetiapine suppresses Aβ1-42-induced activation of primary microglia by decresing proinflammatory cytokines. Quetiapine inhibits the activation of nuclear factor kappa B p65 pathway in both transgenic mice and primary microglia stimulated by Aβ1–42.Conclusions:
The antiinflammatory effects of quetiapine in Alzheimer’s disease may be involved in the nuclear factor kappa B pathway. Quetiapine may be an efficacious and promising treatment for Alzheimer’s disease targeting on neuroinflammation. 相似文献Purpose
Interventional endovascular treatment has become the first line of management in the treatment of peripheral artery disease (PAD). However, contrast and radiation exposure continue to limit the feasibility of these procedures. This paper presents a novel hybrid image fusion system for endovascular intervention of PAD. We present two different roadmapping methods from intra- and pre-interventional imaging that can be used either simultaneously or independently, constituting the navigation system.Methods
The navigation system is decomposed into several steps that can be entirely integrated within the procedure workflow without modifying it to benefit from the roadmapping. First, a 2D panorama of the entire peripheral artery system is automatically created based on a sequence of stepping fluoroscopic images acquired during the intra-interventional diagnosis phase. During the interventional phase, the live image can be synchronized on the panorama to form the basis of the image fusion system. Two types of augmented information are then integrated. First, an angiography panorama is proposed to avoid contrast media re-injection. Information exploiting the pre-interventional computed tomography angiography (CTA) is also brought to the surgeon by means of semiautomatic 3D/2D registration on the 2D panorama. Each step of the workflow was independently validated.Results
Experiments for both the 2D panorama creation and the synchronization processes showed very accurate results (errors of 1.24 and \(2.6 \pm 1.4\) mm, respectively), similarly to the registration on the 3D CTA (errors of \(1.5 \pm 0.7\) mm), with minimal user interaction and very low computation time. First results of an on-going clinical study highlighted its major clinical added value on intraoperative parameters.Conclusion
No image fusion system has been proposed yet for endovascular procedures of PAD in lower extremities. More globally, such a navigation system, combining image fusion from different 2D and 3D image sources, is novel in the field of endovascular procedures.Method: Eight young adults, eight TD 5–8 year-old children, and seven 5–8 year-old children with CIs participated. Labial /ba/–/wa/ and alveolar /da/–/ja/ continua stimuli were presented, with each continuum consisting of nine synthetic stimuli varying in F2 and F3 transition duration. Participants were asked to label the stimuli as either a stop or glide, and responses were analysed for phonetic boundaries and slopes.
Result: For the /ba/–/wa/ contrast, children with CIs required longer transition durations compared to TD children or adults to cross from one phoneme category to another. The children with CIs demonstrated less confidence in labelling the stimuli (i.e. less steep slopes) than the TD children or the adults. For the /da/–/ja/ contrast, the children with CIs showed less steep slope values than adults.
Conclusion: These results suggest that there are differences in the way TD children and children with CIs develop and maintain phonetic categories, perhaps differences in phonetic representation or in linking acoustic and phonetic representations. 相似文献