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Blessing N. R. Jaja Daniel Attalla R. Loch Macdonald Tom A. Schweizer Michael D. Cusimano Nima Etminan Daniel Hanggi David Hasan S. Claiborne Johnston Peter Le Roux Benjamin Lo Ada Louffat-Olivares Stephan Mayer Andrew Molyneux Adam Noble Audrey Quinn Thomas Schenk Julian Spears Jeffrey Singh Michael Todd James Torner Ming Tseng William van den Bergh Mervyn D. I. Vergouwen George K. C. Wong 《Neurocritical care》2014,21(3):551-559
Researchers and other stakeholders continue to express concern about the failure of randomized clinical trials (RCT) in subarachnoid hemorrhage (SAH) to show efficacy of new treatments. Pooled data may be particularly useful to generate hypotheses about causes of poor outcomes and reasons for failure of RCT in SAH, and strategies to improve them. Investigators conducting SAH research collaborated to share data with the intent to develop a large repository of pooled individual patient data for exploratory analysis and testing of new hypotheses relevant to improved trial design and analysis in SAH. This repository currently contains information on 11,443 SAH patients from 14 clinical databases, of which 9 are datasets of recent RCTs and 5 are datasets of prospective observational studies and hospital registries. Most patients were managed in the last 15 years. Data validation and quality checks have been conducted and are satisfactory. Data is available on demographic, clinical, neuroimaging, and laboratory results and various outcome measures. We have compiled the largest known dataset of patients with SAH. The SAHIT repository may be an important resource for advancing clinical research in SAH and will benefit from contributions of additional datasets. 相似文献
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Injuries to peripheral nerves are common and cause life-changing problems for patients alongside high social and health care costs for society. Current clinical treatment of peripheral nerve injuries predominantly relies on sacrificing a section of nerve from elsewhere in the body to provide a graft at the injury site. Much work has been done to develop a bioengineered nerve graft, precluding sacrifice of a functional nerve. Stem cells are prime candidates as accelerators of regeneration in these nerve grafts. This review examines the potential of adipose-derived stem cells to improve nerve repair assisted by bioengineered nerve grafts. 相似文献
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Candice Alexandra Grzelak Luciano Gastón Martelotto Nicholas David Sigglekow Bramilla Patkunanathan Katerina Ajami Sarah Ruth Calabro Benjamin James Dwyer Janina Elke Eleonore Tirnitz-Parker D. Neil Watkins Fiona Jane Warner Nicholas Adam Shackel Geoffrey William McCaughan 《Journal of hepatology》2014
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