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61.
Laribière A Miremont-Salamé G Reyre H Abouelfath A Liège L Moore N Haramburu F 《European journal of clinical pharmacology》2005,61(12):907-911
Objective To describe adverse events occurring after mass vaccination with conjugate and nonconjugate vaccines and to assess the incidence
of serious adverse effects.
Methods A mass immunisation campaign against meningococcal C disease was conducted in two French administrative areas, Landes and
Pyrénées atlantiques, for 2 months (from October to December 2002). Adverse events were reported by families and physicians
by means of a specific reporting form returned to the pharmacovigilance centre 15 days after vaccination.
Results The target population was 260,630 individuals aged between 2 months and 24 years. About 179,000 children and young adults
were vaccinated. A total of 92,711 report forms were received by the pharmacovigilance centre, and 12,695 subjects presented
at least one adverse event. The most frequently involved systems/disorders were application site disorders (48.4%), whole-body
general disorders (21.8%), central and peripheral nervous system disorders (14.6%), and gastrointestinal system disorders
(4.7%). Most of these adverse events were transient and not serious. There were 13 serious adverse events: one each of syncope,
fever, headache with fever, neuralgia, serum sickness, arthritis, purpura, facial paralysis, multiple sclerosis, lipoma, and
meningism, and two cases of bronchospasm. No significant difference was found in rates of adverse event reports between both
vaccines. The estimated incidence of serious adverse effect reports was 7 per 100,000.
Conclusions This campaign was the second immunisation campaign undertaken in France involving both physicians and families as reporters.
Although unlabeled adverse effects were identified during this campaign, they were mostly nonserious and have been known to
occur with other vaccines. 相似文献
62.
Bégaud B Martin K Abouelfath A Tubert-Bitter P Moore N Moride Y 《European journal of epidemiology》2005,20(3):213-216
Despite the ever larger choice of softwares and statistical packages allowing fast and accurate computation of binomial and Poisson confidence limits, there is always a need for a simple and reliable formula allowing non-computerized computations. The method proposed in this paper is derived from the Freeman and Tukeys variance stabilizing transformation for a random Poisson variable and adjusted for giving the best fit with the exact Poisson values. Despite its simplicity, allowing its use in any circumstances, this method provides very satisfactory results and a much better fit than classical formula based on the normal approximation, even if a continuity correction is used. It allows computation of Poisson confidence limits both for count or rates and proportions. 相似文献
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Meriem Boui Hammoune Nabil Slioui Badr BenElhend Salah Zouaki Zakaria Bellasri Salah Atmane Mehdi Mouhsine Abdelilah Akka Rachid Raissi Abderrahim 《Radiology Case Reports》2021,16(11):3589
Obesity is a real public health problem and is of growing concern. People are resorting to surgical or endoscopic means to fight against overweight and obesity. In recent years, there has been a marked increase in the use of these means and in particular the insertion of a gastric balloon which seems to present less risk than surgical methods. Renal complications from intragastric balloon placement are extremely rare. We report here the case of compression of the left renal vein revealed by lumbar pain and hematuria in an overweight 39-year-old woman who benefited from the balloon gastric placement one month before symptoms. The scanner made the diagnosis and showed a good evolution after the withdrawal of the balloon. 相似文献
65.
Fanny Depont Elke Hunsche Abdelilah Abouelfath Thierno Diatta Isabelle Addra Angela Grelaud Rajaa Lagnaoui Mathieu Molimard Nicholas Moore 《Fundamental & clinical pharmacology》2010,24(1):101-108
A retrospective, observational, cohort study in primary care. To determine the total direct medical and non-medical cost of chronic low back pain (LBP) in France and its associated factors. Chronic LBP affects 5–10% of the population its burden in France is unknown. Ninety-eight randomly selected general practitioners included 796 adult patients with chronic LBP between October 2001 and December 2002. Direct costs due to physician visits, investigations, medications, hospitalizations, and other medical and non-medical resource use were collected for the 6 months prior to study visit. Costs both reimbursed and not by the French health insurance system were considered. Quality of life (QoL) and disease severity were measured using Short Form (SF)-8 and Roland-Morris disability questionnaire (RMDQ), respectively. Costs were updated to represent 2007 prices. Men represented 50.6% of the 796 patients, mean age was 53 ± 11.3 years, and the duration of LBP was more than 1 year in 80.9% of patients. The total mean cost per patient over six months was 715.6€ (95% CI: 644.2–797.8). Of these costs, 22.9% related to care provided by physiotherapists and allied specialists, 19.5% to medications, 17.4% to hospitalizations, 9.6% to investigations, and 12.5% to physician fees. In multivariate analysis, the factors associated with the cost of chronic LBP were disease severity (RMDQ score) and age of the patients. LBP is a disease that is both common and costly. 相似文献
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L Laraqui A Amarti F Zouaidia M Maher F Kettani A Saidi 《Revue de pneumologie clinique》2001,57(3):225-228
Glioblastoma is a primary malignant astrocyte tumor of the central nervous system. Extraneural metastasis is uncommon. We report a case of spontaneous lung metastasis from a glioblastoma without prior surgery. Positive diagnosis was achieved from histology and immunohistochemistry 相似文献