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排序方式: 共有1371条查询结果,搜索用时 15 毫秒
991.
Weber M Daurès JP Fabre N Druais PL Dardenne J Slama A El Hasnaoui A 《Revue neurologique》2002,158(4):439-445
The subjective aspects of the doctor-patient relationship may impact disease management methods applied to migraine patients. This prospective study compared the medical attitudes of doctors towards migraine headache in relationship to their personal sensitivity to this disease. The study concerned data on the health care management of migraine headache by 711 general practitioners, 325 of whom suffer from migraine headache themselves, 227 who do not suffer from migraines, but who have a close family member that does, and 159 who neither suffer from migraine headache, nor have anyone close who does. Each doctor filled out a medical practice questionnaire concerning this pathology and included one migraine patient in the survey. Each patient answered a specific quality of life questionnaire. It was shown that doctors suffering from migraine headache themselves declared having more migraine patients in their practices than the other doctors. Nonetheless, the doctor's sensitivity to migraine headache does not seem to have an impact on the diagnosis and therapeutic care of patients; diagnosis criteria are the same within the three groups and correspond to international headache society criteria. Furthermore, the therapeutic means applied, whether acute first or second intention treatment, or long-term treatment, do not differ amongst the three groups. Quality of life and patients' feelings about medical support were significantly related to the doctor's level of sensitivity towards the disease: they were highest amongst patients treated by doctors suffering from migraines themselves, and lowest amongst patients treated by doctors with no close family members suffering from migraines. Although therapeutical attitudes do not vary, the quality of life perceived by patients is better when the doctors themselves are concerned by the disease. 相似文献
992.
Imen Arfa Abdelmajid Abid Sonia Nouira Houda Elloumi-Zghal Dhafer Malouche Imen Mannai Mohamed Majdi Zorgati Nissaf Ben Alaya Ahmed Rebai Béchir Zouari Slim Ben Ammar Mohamed Chiheb Ben Rayana Slama Hmida Samira Blousa-Chabchoub Sonia Abdelhak 《Journal of the renin-angiotensin-aldosterone system》2008,9(1):32-36
OBJECTIVE: The aim of the present study was to investigate whether the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with diabetic nephropathy and type 2 diabetes in the Tunisian population. DESIGN: A case-control study was conducted among 141 unrelated type 2 diabetic patients with (90 patients) or without nephropathy (51 patients) and 103 non-diabetic controls with normal fasting blood glucose. Genotyping was performed using a nested polymerase chain reaction amplification in order to identify correctly heterozygous individuals. RESULTS: The distribution of DD, ID and II genotypes did not significantly differ between type 2 diabetic patients with or without nephropathy (DD: 44%; ID: 46%; II: 10% vs. DD: 41%; ID: 47 %; II: 12%, respectively). There was also no significant statistical difference between the genotype distribution and allele frequencies of the (I/D) polymorphism in all type 2 diabetic subjects compared to non-diabetic controls with normal fasting blood glucose (DD: 43%; ID: 46%; II: 11% vs. DD: 37%; ID: 48%; II: 15%, respectively). CONCLUSIONS: In the present preliminary study, the (I/D) polymorphism within the ACE gene is likely not associated with diabetic nephropathy nor with type 2 diabetes in the Tunisian studied population. 相似文献
993.
Zmerli S Ayed M Horchani A Chami I El Ouakdi M Ben Slama MR 《World journal of surgery》2001,25(1):68-74
apd: 18 December 2000 相似文献
994.
995.
996.
Massy ZA Mazière C Kamel S Brazier M Choukroun G Tribouilloy C Slama M Andrejak M Mazière JC 《Pediatric nephrology (Berlin, Germany)》2005,20(3):380-382
Vascular and/or valvular calcifications in patients with chronic kidney disease (CKD) appear to indicate a poor prognosis in terms of overall survival and cardiovascular morbidity and mortality. Inflammation and oxidative stress represent new features of the arterial and/or valvular calcification process. However, only limited observational and epidemiological data are available in these areas. Therefore, the link between inflammation, oxidation and vascular and/or valvular calcifications deserves careful consideration in CKD patients, since they may become targets for the development of new therapeutic strategies.This work was presented in part at the IPNA Seventh Symposium on Growth and Development in Children with Chronic Kidney Disease: The Molecular Basis of Skeletal Growth, 1–3 April 2004, Heidelberg, Germany 相似文献
997.
Said G Lacroix C Planté-Bordeneuve V Messing B Slama A Crenn P Nivelon-Chevallier A Bedenne L Soichot P Manceau E Rigaud D Guiochon-Mantel A Matuchansky C 《Journal of neurology》2005,252(6):655-662
We report on four patients
with severe polyneuropathy
associated with intestinal pseudoobstruction
(MNGIE). Three patients
presented characteristic
supranuclear ophthalmoplegia, and
hyperdense signals on T2 weighted
cerebral MRI and dystrophic mitochondria
in Schwann cells and in
endothelial cells in nerve biopsy
specimens. Two of these patients
had a Charcot–Marie–Tooth (CMT)
presentation. All three were heterozygous
for a recessively transmitted
double substitution in the
TP gene: Glu286Lys/Glu289Ala,
Asp156Gly/Leu177Pro and
Glu289Ala/Gly387Asp. The fourth
patient, who was the only patient of
this series with an affected sib, had
no oculomotor manifestations, nor
T2 hyperdense signals on brain
MRI, and no TP gene mutation and
or morphological abnormalities of
mitochondria on electron microscopic
examination. He was the
only patient of this series with an
affected sib. The three patients with
the full MNGIE syndrome died before
the age of 30 years. Detailed
results of nerve pathology show
that severe axonal degeneration is
associated with segmental abnormalities
of the myelin sheath in
this syndrome which appears genetically
heterogeneous. Our findings
suggest that only ophthalmoplegia
and hyperdense signals on
cerebral MRI are directly related to
the mitochondriopathy. 相似文献
998.
Immediate allergy to natural latex has been on the icrease for the last decade in exposed persons and particularly the health personnel. Its prevalence is variable from one study to another. To evaluate the prevalence of later allergy in our nursing staff, we carried out an inguiry in two hospitals in Sousse. It's a prospective study involving 300 subjects and based on an anonymous questionnaire and a cutaneous prik test for latex allergy and atopy. The population was composed of 188 women an 112 men ith an average age of 35 years. There were 97 nurses of either sex, 65 doctors, 58 workers, 30 with technicians, 27 anesthetists, 17 midwives and 6 pharmacists. Sixty subjects (5.3%) showed a positive prick test ot latex: 11 women and 5 mon of different professional groups. The prevalence of atopy in this latex positive population (81%) was greater than in the latex negative population (25%). An associate alimentary allergy was identified in 10 patients allergic to latex. A study of specific immunoglobulins to latex carried out in 12 cases was positive in three patients. The provocation test for gloves was positive in 38% of cases. 相似文献
999.
Slama TG 《The Journal of family practice》2005,(Z1):S15-S17
Identification of risk factors present in the medical history should alert physicians to patients at potentially high risk for drug-induced QT interval prolongation. Careful patient monitoring and treatment adjustment will aid physicians in avoiding the complications of QT interval prolongation. 相似文献
1000.
Influence of paternal age on the risk of spontaneous abortion 总被引:5,自引:0,他引:5
Slama R Bouyer J Windham G Fenster L Werwatz A Swan SH 《American journal of epidemiology》2005,161(9):816-823
The frequency of chromosomal anomalies in spermatozoa appears to increase with male age. Because these anomalies play a role in the etiology of spontaneous abortion, an influence of paternal age on risk of spontaneous abortion is plausible but not established. The aim was to characterize this influence in a prospective study among 5,121 California women, who as members of a prepaid health plan were interviewed in 1990 or 1991 when they were less than 13 weeks' pregnant and who were followed until the end of pregnancy. The risk of spontaneous abortion between weeks 6 and 20 of pregnancy was studied using a Cox model adjusted for maternal age. The adjusted hazard ratio of spontaneous abortion associated with paternal age of 35 years or more, compared with less than 35 years, was 1.27 (95% confidence interval: 1.00, 1.61), with no modification by maternal age. Among women aged less than 30 years, the hazard ratio of spontaneous abortion associated with paternal age of 35 years or more was 1.56 for first trimester spontaneous abortion and 0.87 for early second trimester spontaneous abortion (test of interaction, p = 0.25). In conclusion, the risk of spontaneous abortion increased with increasing paternal age, with a suggestion that the association is stronger for first trimester losses. 相似文献