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NEIL SULKE PHYLLIS HOLT JULIAN BOSTOCK ALAN YATES EDGAR SOWTON 《Pacing and clinical electrophysiology : PACE》1990,13(9):1123-1126
Inappropriate shocks were delivered to a patient while in sinus rhythm by an implantable cardioverter defibrillator (ICD) during routine prehospital discharge testing. This was induced by the standard programmer when the "read" telemetry sequence was initiated. The ICD was removed and found to suffer from electrical artifact that was sensed as ventricular tachycardia during telemetry. To avoid inadvertent telemetry-induced shocks during routine testing, all ICDs should be interrogated, using a standard programmer, intraoperatively, with the unit in "defibrillation on" mode. 相似文献
23.
KARUNA CHILUKURI DARSHAN DALAL SHRIRANG GADREY JOSEPH E. MARINE EDWIN MACPHERSON CHARLES A. HENRIKSON ALAN CHENG SAMAN NAZARIAN SUNIL SINHA DAVID SPRAGG RONALD BERGER HUGH CALKINS 《Journal of cardiovascular electrophysiology》2010,21(5):521-525
Effect of Obesity and OSA on Outcomes Post AF Ablation . Background: Obesity and obstructive sleep apnea (OSA) have a strong association with atrial fibrillation (AF). The purpose of this study was to prospectively determine the effects of obesity, assessed by the body mass index (BMI) and OSA on the efficacy of catheter ablation of AF. Methods: The patient population consisted of 109 patients (mean age: 60 ± 10 years, 79% male, 67% paroxysmal, mean BMI 28 ± 5 kg/m2) who underwent catheter ablation of AF. Based on BMI, patients were classified as normal (<25 kg/m2), overweight (≥25 and <30 kg/m2), or obese (≥30 kg/m2). OSA was assessed by the Berlin questionnaire. Clinical success was defined as at least 90% reduction in AF burden after 3‐month blanking period. Mean duration of follow‐up was 11 ± 4 months. Results: Of the 75 patients with clinical success, 25 (33%) had normal BMI, 29 (39%) were overweight, and 21 (28%) were obese. Among the 34 patients with failed outcome, 5 (15%) had normal BMI, 14 (41%) were overweight, and 15 (44%) were obese (P = 0.04). Twenty‐eight of the 48 patients with OSA (58%) had clinical success as opposed to 47 of the 61 patients (77%) without OSA (P = 0.036). On multivariate analysis, only BMI emerged as an independent predictor of procedural failure ((OR 1.11, CI: 1.00–1.21, P = 0.03). Conclusions: The results of this prospective study show that obesity, a modifiable risk factor, is an independent predictor of procedural failure after catheter ablation of AF. Whether treating obesity may improve the results of catheter ablation of AF warrants further investigation. (J Cardiovasc Electrophysiol, Vol. 21, pp. 521‐525, May 2010) 相似文献
24.
Defensive hostility and anger expression: Relationship to additional heart rate reactivity during active coping 总被引:4,自引:0,他引:4
The main purpose of the present study was twofold: (a) to assess the relationship between defensive hostility (high hostility/high defensiveness) and additional heart rate reactivity during active coping and (b) to determine if the construct of anger-out might lend additional, sensitivity to the predictive power of the defensive hostility model. Forty individuals were randomly assigned to complete a mental arithmetic task with or without the threat of shock. Participants also completed the Cook-Medley Hostility Inventory (Ho), the Marlowe-Crowne Social Desirability Scale (MC), and the Spielberger Anger Expression Scale. Defensive hostile subjects (high Ho/high MC) were significantly more reactive than any other subgroup. In addition, the combination of low Ho/high anger-out scores yielded a subgroup significantly less reactive than any other subgroup. These findings clarify the complex relationship of hostility and cardiovascular reactivity. 相似文献
25.
Distribution of matrix metalloproteinases and their inhibitor, TIMP-1, in developing human osteophytic bone 总被引:3,自引:0,他引:3
SHARYN BORD ALAN HORNER ROSALIND M. HEMBRY JOHN J. REYNOLDS JULIET E. COMPSTON 《Journal of anatomy》1997,191(1):39-48
Connective tissues synthesise and secrete a family of matrix metalloproteinases (MMPs) which are capable of degrading most components of the extracellular matrix. Animal studies suggest that the MMPs play a role in bone turnover. Using specific polyclonal antisera, immunohistochemistry was used to determine the patterns of synthesis and distribution of collagenase (MMP-1), stromelysin (MMP-3), gelatinase A (MMP-2) and gelatinase B (MMP-9) and of the tissue inhibitor of metalloproteinases-1 (TIMP-1) within developing human osteophytic bone. The different MMPs and TIMP showed distinct patterns of localisation. Collagenase expression was seen at sites of vascular invasion, in osteoblasts synthesising new matrix and in some osteoclasts at sites of resorption. Chondrocytes demonstrated variable levels of collagenase and stromelysin expression throughout the proliferative and hypertrophic regions, stromelysin showing both cell-associated and strong matrix staining. Intense gelatinase B expression was observed at sites of bone resorption in osteoclasts and mononuclear cells. Gelatinase A was only weakly expressed in the fibrocartilage adjacent to areas of endochondral ossification. There was widespread but variable expression of TIMP-1 throughout the fibrous tissue, cartilage and bone. These results indicate that MMPs play a role in the development of human bone from cartilage and fibrous tissue and are likely to have multiple functions. 相似文献
26.
STEPHEN C. H. SMITH Biochemist ALAN M. BOLD Consultant Chemical Pathologist 《BJOG : an international journal of obstetrics and gynaecology》1983,90(6):532-534
Summary. In-vitro thyroid function tests are difficult to interpret in pregnancy because of, among other things, the effect of oestrogens on thyroid binding globulin (TBG) concentrations. In an attempt to clarify the position, serum concentrations of total thyroxine (T4 ), free T4 , TBG, T4 /TBG ratio, tri-iodothyronine (T3 ) and thyroid stimulating hormone (TSH) were measured. Total T4 and TBG concentrations rose to above the non-pregnant reference range by 20 weeks. The T4 /TBG ratio fell to hypo-thyroid values by 20 weeks but although the free T4 level was lower in the third trimester compared with values in the first and second trimesters, only a few subjects had hypothyroid values. The TSH values remained unchanged throughout pregnancy. The significance of these changes is discussed and reference ranges for these hormones at each trimester are provided. 相似文献
27.
ALAN D. BERNSTEIN A. JOHN CAMM JOHN D. FISHER ROSS D. FLETCHER R. HARDWIN MEAD ANTHONY W. NATHAN VICTOR PARSONNET ANTHONY F. RICKARDS NICHOLAS P.D. SMYTH RICHARD SUTTON PETER P. TARJAN 《Journal of interventional cardiology》1993,6(3):235-239
BERNSTEIN, A.D., et al .: The NASPE/BPEG Defibrillator Code. A new generic code, patterned after and compatible with the NASPE/BPEG Generic Pacemaker Code (NBG Code) was adopted by the NASPE Board of Trustees on January 23, 1993. It was developed by the NASPE Mode Code Committee, including members of the North American Society of Pacing and Electrophysiology (NASPE) and the British Pacing and Electrophysiology Group (BPEG). It is abbreviated as the NBD (for NASPE/BPEG Defibrillator) Code. It is intended for describing the capabilities and operation of implanted cardioverter defibrillators (ICDs) in conversation, record keeping, and device labeling, and incorporates four positions designating: (1) shock location; (2) antitachycardia pacing location; (3) means of tachycardia detection; and (4) antibradycardia pacing location. An additional Short Form, intended only for use in conversation, was defined as a concise means of distinguishing devices capable of shock alone, shock plus antibradycardia pacing, and shock plus antitachycardia and antibradycardia pacing. (PACE, Vol. 16, September 1993) 相似文献
28.
A number of different but complementary approaches have been used to demonstrate the immunogenicity of Necator americanus acetylcholinesterase to infected individuals. Western blotting of parasite somatic extracts with human post-infection sera and a specific rabbit antiserum to AChE resulted in the development of almost identical antigen-recognition profiles. AChE-containing fractions produced by preparative iso-electric focusing were subsequently shown to be antigenic in ELISA using post-infection sera. This preliminary data was reinforced by the affinity-purification of AChE by immobilized post-infection IgG, and the immunoprecipitation of AChE activity from ES by post-infection IgG. Finally, AChE purified by affinity chromatography on edrophonium chloride was shown to be antigenic by Western blotting, and in ELISA, against post-infection sera, although a degree of re-activity was also seen with normal human sera. This data is discussed in the context of the host-parasite relationship. 相似文献
29.
30.
ALAN R. FELTHOUS 《Criminal behaviour and mental health : CBMH》1993,3(1):12-18
For most people most of the time nocturnal dreams seem to have a life of their own with little, if any, recognisable relevance to life in the waking state. Freud and other theorists have attempted to relate nocturnal dreams to underlying impulses and conflicts which also affect one's mental state when awake. In only a few mental disorders has the manifest content of dreams achieved widely accepted diagnostic significance. The case presented here demonstrates that a patient's tenuous hold on reality can allow manifest dream content to direct the patient's waking behaviour. In this case the dream content seemed to identify the potential victim and to prime the patient to take violent action. For the astute clinician, careful attention to violent dreams may help to anticipate both violent acts and specific victims and to make appropriate, preventive interventions. 相似文献