全文获取类型
收费全文 | 463篇 |
免费 | 34篇 |
专业分类
儿科学 | 28篇 |
妇产科学 | 6篇 |
基础医学 | 49篇 |
口腔科学 | 14篇 |
临床医学 | 65篇 |
内科学 | 93篇 |
皮肤病学 | 14篇 |
神经病学 | 10篇 |
特种医学 | 131篇 |
外科学 | 16篇 |
综合类 | 13篇 |
预防医学 | 18篇 |
眼科学 | 1篇 |
药学 | 18篇 |
肿瘤学 | 21篇 |
出版年
2023年 | 1篇 |
2022年 | 5篇 |
2021年 | 8篇 |
2020年 | 1篇 |
2019年 | 4篇 |
2018年 | 11篇 |
2017年 | 4篇 |
2016年 | 6篇 |
2015年 | 13篇 |
2014年 | 8篇 |
2013年 | 28篇 |
2012年 | 4篇 |
2011年 | 5篇 |
2010年 | 23篇 |
2009年 | 26篇 |
2008年 | 3篇 |
2007年 | 5篇 |
2006年 | 6篇 |
2005年 | 4篇 |
2004年 | 6篇 |
2003年 | 3篇 |
2002年 | 2篇 |
2001年 | 5篇 |
2000年 | 2篇 |
1999年 | 7篇 |
1998年 | 28篇 |
1997年 | 29篇 |
1996年 | 32篇 |
1995年 | 24篇 |
1994年 | 25篇 |
1993年 | 21篇 |
1992年 | 3篇 |
1991年 | 7篇 |
1990年 | 3篇 |
1989年 | 16篇 |
1988年 | 12篇 |
1987年 | 12篇 |
1986年 | 9篇 |
1985年 | 9篇 |
1984年 | 6篇 |
1983年 | 6篇 |
1982年 | 8篇 |
1981年 | 9篇 |
1980年 | 3篇 |
1979年 | 5篇 |
1978年 | 7篇 |
1977年 | 13篇 |
1976年 | 8篇 |
1975年 | 10篇 |
1968年 | 2篇 |
排序方式: 共有497条查询结果,搜索用时 0 毫秒
91.
92.
93.
Schuler PJ Trellakis S Greve J Bas M Bergmann C Bölke E Lehnerdt G Mattheis S Albers AE Brandau S Lang S Whiteside TL Bier H Hoffmann TK 《European journal of medical research》2010,15(8):337-344
Background
Systemic treatment of head and neck squamous cell carcinoma (HNSCC) includes a variety of antineoplastic drugs. However, drug-resistance interferes with the effectiveness of chemotherapy. Preclinical testing models are needed in order to develop approaches to overcome chemoresistance.Methods
Ten human cell lines were obtained from HNSCC, including one with experimentally-induced cisplatin resistance. Inhibition of cell growth by seven chemotherapeutic agents (cisplatin, carboplatin, 5- fluorouracil, methotrexate, bleomycin, vincristin, and paclitaxel) was measured using metabolic MTT-uptake assay and correlated to clinically-achievable plasma concentrations.Results
All drugs inhibited cell growth in a concentration-dependent manner with an IC50 comparable to that achievable in vivo. However, response curves for methotrexate were unsatisfactory and for paclitaxel, the solubilizer cremophor EL was toxic. Cross-resistance was observed between cisplatin and carboplatin.Conclusion
Chemosensitivity of HNSCC cell lines can be determined using the MTT-uptake assay. For DNA-interfering cytostatics and vinca alkaloids this is a simple and reproducible procedure. Determined in vitro chemosensitivity serves as a baseline for further experimental approaches aiming to modulate chemoresistance in HNSCC with potential clinical significance. 相似文献94.
95.
96.
R Mitchell Baldwin Gordon M Barrett Doris AE Parolin Jana K Gillies Judith A Paget Sylvie J Lavictoire Douglas A Gray Ian AJ Lorimer 《Molecular cancer》2010,9(1):233
Background
Glioblastoma is one of the deadliest forms of cancer, in part because of its highly invasive nature. The tumor suppressor PTEN is frequently mutated in glioblastoma and is known to contribute to the invasive phenotype. However the downstream events that promote invasion are not fully understood. PTEN loss leads to activation of the atypical protein kinase C, PKCι. We have previously shown that PKCι is required for glioblastoma cell invasion, primarily by enhancing cell motility. Here we have used time-lapse videomicroscopy to more precisely define the role of PKCι in glioblastoma. 相似文献97.
98.
Osteoprotegerin: A novel biomarker for inflammatory bowel disease and gastrointestinal carcinoma
下载免费PDF全文
![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Floris AE De Voogd Richard B Gearry Christopher J Mulder Andrew S Day 《Journal of gastroenterology and hepatology》2016,31(8):1386-1392
Osteoprotegerin (OPG) is a member of the tumor necrosis factor receptor superfamily of proteins. Although initial data illustrated the key role that OPG plays in bone turnover, numerous recent reports indicate that OPG is also an important factor in inflammatory pathways and tumor cell survival. OPG contributes directly to inflammatory processes and has been evaluated as a novel non‐invasive biomarker of gut inflammation. Furthermore, OPG affects cell turn‐over, differentiation, death, and survival via extracellular pathways, correlating with worse prognosis in inflammatory bowel diseases and several gastrointestinal carcinomas. It is now clear that OPG has multiple functions and characteristics. This review gives an overview of OPG, highlights its roles in different extracellular pathways, and outlines how OPG could be used as a novel non‐invasive biological marker in inflammatory bowel diseases and gastrointestinal carcinomas. 相似文献
99.
100.