虚拟实验室在分子诊断学教学中的应用

虚拟实验室是一个计算机网络化的仿真实验环境,具有沉浸感和交互性的特点。分子诊断学虚拟实验室用于教学,在增强学生学习兴趣、提高教学质量和培养学生综合素质等方面取得了显著效果。     

Adjuvant systemic chemotherapy for Stage II and III colon cancer after complete resection: an updated practice guideline

Aims

The standard adjuvant therapy for resected stage III colon cancer has been intravenous 5-fluorouracil. However, newer chemotherapy agents, such as capecitabine, oxaliplatin and irinotecan, have been investigated in clinical trials since the publication of the original guidelines. The Gastrointestinal Cancer Disease Site Group (DSG) conducted a systematic review of the evidence for the use of adjuvant systemic chemotherapy for patients with resected stage II and III colon cancer and developed an updated practice guideline based on that evidence and expert consensus. The following research questions were addressed: Should patients with stage II or III colon cancer receive adjuvant systemic chemotherapy? What are the preferred adjuvant systemic chemotherapy options for patients with completely resected stage II or III colon cancer? Outcomes of interest were disease-free survival, overall survival, adverse effects and quality of life.

Materials and methods

A systematic search of published studies was conducted for the time period following the publication of the original guidelines to identify relevant randomised trials and syntheses of evidence in the form of meta-analyses. Recommendations were based on that evidence, evidence contained in the original guidelines and consensus of the Gastrointestinal Cancer DSG. The systematic review and practice guideline were externally reviewed through a mailed survey of practitioners in Ontario, Canada.

Results

Recommendations were drafted based on the available evidence and expert consensus.

Conclusions

The routine use of adjuvant chemotherapy for all patients with stage II colon cancer is not recommended. However, a subset of patients with high-risk stage II disease should be considered for adjuvant therapy. Patients with completely resected stage III colon cancer should be offered adjuvant chemotherapy. Treatment should depend on factors such as patient suitability and preference, and patients and clinicians must work together to determine the optimal course of treatment.     

血清CA19-9水平可能做为非小细胞肺癌转移的一个指标(英文)

Objective  

The aim of our study was to evaluate the serum levels of CA19-9 in patients with non-small cell lung cancer (NSCLC) and to analyze the relationship between serum levels of CA19-9 and metastasis.     

病例对照Meta分析显示男性乳腺癌与女性乳腺癌预后相同

Objective: Male breast cancer (MBC) is a rare disease, and studies to compare the prognosis between the MBC and female breast cancer (FBC) available now were case-control studies and population-based studies, however, with controversial outcomes. To further investigate whether sex affects the prognosis of breast cancer, we performed a meta-analysis based on all the peered papers. Methods: The PubMed database was screened. Subsequently, the hazard ratios (HRs) for overall survival (OS) and disease special su...     

42例完全腹腔镜脾切除术患者的护理

自1991年Delaitre等报道首例腹腔镜脾切除术（laparoscopic spleneetomy,LS）后,随着腹腔镜技术的成熟和经验的积累,腹腔镜脾脏手术在世界范围被逐渐推广和普及,LS已成为腹部外科最常见的腹腔镜实质脏器手术,已成为一定范围内脾切除的标准术式。开展初期的腹腔镜脾切除术部分禁忌症,现已成为手术的适应症,手术范围逐步扩大。有研究报道LS的术后并发症低于传统开腹手术。     

9例妊娠合并HIV感染患者母婴阻断措施探讨

目的:探讨妊娠合并HIV感染患者母婴阻断的措施.方法:9例产前常规HIV抗体筛查阳性患者,采取抗病毒药物治疗、选择性剖宫产、人工喂养等母婴阻断措施.结果:7例随访婴儿HIV检测目前均为阴性.结论:产前HIV检测、综合母婴阻断措施是控制儿童艾滋病流行的重要措施.     

老年人髋部骨折的手术治疗

目的 探讨老年髋部骨折的手术治疗效果,减少髋部骨折并发症,降低病残和病死率.方法 总结1999年1月～2007年9月共收治的126例髋部(股骨颈和粗隆间)骨折患者进行手术治疗及围手术期处理的措施.结果 126例中大部分病例髋关节功能恢复满意,优良率为91.2%;术后并发症发生率11.9%,病死率3.9%.结论 老年髋部骨折手术风险大,多伴有内科疾患,老年人代偿能力低,做好术前评估、有效控制并存症、积极围手术期治疗是手术内固定成功的重要条件.髋部骨折行手术治疗是安全有效的.     

Relationship of GSTM1 and GSTT1 genetic variant and markers of oxidative stress and inflammation in smokers with coronary artery disease

Objective:To investigate the role of glutathione S-transferase (GST) genetic variants and markers of oxidative stress and inflammation in smoking-related coronary artery disease (CAD) patients. Methods:Five hundred and thirty-five Chinese CAD patients were successfully genotyped. Plasma total antioxidant status (TAOS), glutathione, C-reactive protein (CRP), fibrinogen(FIB) and white blood cell count (WBC) were determined to evaluate the oxidative stress and inflammatory response. Results: GSTM1-0/GSTT1-0 su...     

以医学模拟教学为辅助平台构建临床基本技能训练整合课程的探索

临床基本技能训练是医学教育的重要内容,由于传统教学模式的局限,医学生临床技能训练受到较多限制。本文对以医学模拟教学为辅助平台的整合的临床基本技能课程的构建进行探讨,使临床基本技能训练贯穿于医学生在校教育的全过程,从而提高医学生的临床基本技能。     

某高校医学院临床带教质量调查分析

临床带教教师的素质高低直接影响到教学质量。目前临床实习教师带教情况不容乐观,结合对临床带教教师和实习生的问卷调查,针对调查结果,分析其原因并提出解决问题的几点建议。