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Objective To retrospectively analyze the therapeutic results of patients with initially di-agnosed metastatic nasopharyngeal carcinoma (NPC). Methods From January 1995 to December 1998, 46 NPC patients with distant metastases were treated in Fujian provincial cancer hospital. Among these pa-tients, 43 were single site metastasis and 3 were multiple sites metastases;The site of metastasis were 19 pa-tients in the liver, 11 in the bone, 7 in the lung, 1 in the brain, 6 in mediastinal nodes and 6 in axillary lymph nodes. All patients received standard radiotherapy to the primary site and cervical node region with a median dose of 72 Gy. Forty-one patients (89%) received 1-5 cycles chemotherapy (cisplatin and 5-flu-orouracil), and 23 (50%) received palliative irradiation to the metastatic site. Results The median surviv-al time was 20 months. The 1-, 2-, 3-year and 5-year overall survival rates were 66%, 47%, 30% and 19%, respectively. Irradiation to the metastatic sites and KPS were the significant prognostic factors. Pa-tients with palliative irradiation to the metastatic site had longer survival than those without (39 months vs. 13 months, X2=8.63, P=0.012). Patients with good performance status (KPS≥80) had better outcomes thanthose with poor performance status (26 months vs. 12 months, X2= 3.95, P=0.035) . Conclusions Active therapy may prolong the survival of patients with initially diagnosed metastatic NPC, especially for those who have good performance status. Under systematic chemotherapy, radiotherapy to the primary site and supportive care, the palliative irradiation to the metastatic site may also yield a good result. 相似文献
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Objective To retrospectively analyze the therapeutic results of patients with initially di-agnosed metastatic nasopharyngeal carcinoma (NPC). Methods From January 1995 to December 1998, 46 NPC patients with distant metastases were treated in Fujian provincial cancer hospital. Among these pa-tients, 43 were single site metastasis and 3 were multiple sites metastases;The site of metastasis were 19 pa-tients in the liver, 11 in the bone, 7 in the lung, 1 in the brain, 6 in mediastinal nodes and 6 in axillary lymph nodes. All patients received standard radiotherapy to the primary site and cervical node region with a median dose of 72 Gy. Forty-one patients (89%) received 1-5 cycles chemotherapy (cisplatin and 5-flu-orouracil), and 23 (50%) received palliative irradiation to the metastatic site. Results The median surviv-al time was 20 months. The 1-, 2-, 3-year and 5-year overall survival rates were 66%, 47%, 30% and 19%, respectively. Irradiation to the metastatic sites and KPS were the significant prognostic factors. Pa-tients with palliative irradiation to the metastatic site had longer survival than those without (39 months vs. 13 months, X2=8.63, P=0.012). Patients with good performance status (KPS≥80) had better outcomes thanthose with poor performance status (26 months vs. 12 months, X2= 3.95, P=0.035) . Conclusions Active therapy may prolong the survival of patients with initially diagnosed metastatic NPC, especially for those who have good performance status. Under systematic chemotherapy, radiotherapy to the primary site and supportive care, the palliative irradiation to the metastatic site may also yield a good result. 相似文献
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腕舟骨骨折是常见的骨折,由于其特殊的血供特点及解剖位置,骨不愈合的发生率为5%~10%,治疗较困难[1-2].2007年2月至2010年8月,我院采用带桡动脉茎突支桡骨骨瓣移植治疗腕舟骨骨折不愈合19例,疗效满意.资料与方法本组男12例,女7例.年龄21 ~ 45岁.病程8个月~12年.骨折部位:舟骨腰部骨折17例、近侧t/3骨折2例,其中3例近端缺血性坏死.临床表现:腕关节酸疼,持物时明显,握力下降,鼻烟窝区压痛.X线片显示:骨折线清晰,骨折断端硬化,断端骨吸收.近折端呈囊性变3例. 相似文献
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韩露 《中国药理学与毒理学杂志》2018,(11):852-854
网络药理学的提出是药理学的一大进步,它标志着药理学的研究从传统的一药一靶,一钥匙一锁的研究思想走向了系统化的研究模式[1]。在过去十年的网络药理学研究中,网络及网络科学中的多种度量指标成为了药理研究中的描述和研究工具,为药物新用途发现及药物治疗理论的完善提供了全新视角。 相似文献
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2021年7月29日,中国工程院重点咨询项目“中西医结合疾病防控人才学科体系建设”课题组对吴以岭院士进行了专访,访谈的核心内容是中医治未病与建立中西医结合疾病防控体系。吴院士表示:中医治未病和中西医结合防控体系的建立,对推进健康中国建设,提高人民健康水平发挥着至关重要的作用。其关键是找到学科的交叉点,即中西医结合。 相似文献
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乳头状和滤泡状甲状腺癌的处理 总被引:2,自引:0,他引:2
韩露 《国外医学:内分泌学分册》2001,21(2):81-82
由于乳头状和滤泡状甲状腺癌确诊时病人的年龄,癌瘤所长的阶段和初期治疗的不同,其预后有很大别。及时、合理的初期治疗及长期密切的随访,可使90%的病人人长期存活,最佳的治疗方案是甲状腺近全切和术后及时的I^131治疗。随访分为3期,主要的临床测指标是全身扫描和血清Tg测定。 相似文献
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目的 研究不同剂量羊瘙痒因子263 K经颅内注射感染仓鼠后,在发病的终末期星形胶质细胞增生程度是否与注射剂量及潜伏期长短有关.方法 以胶质纤维酸性蛋白(glial fibrill aryacidic protein,GFAP)作为星形胶质细胞增生的分子标志物,采用Western Blot和免疫组化方法检测感染仓鼠终末期脑匀浆和脑组织病理切片中的GFAP表达,经定量分析比较各感染剂量组间是否存在差异.结果与正常对照相比,不同剂量感染仓鼠发病终末期脑组织GFAP阳性细胞数量和总GFAP含量均明显升高,但各感染剂量组间无显著差异.结论 不同感染剂量羊瘙痒因子263K经颅内注射感染仓鼠在发病终末期脑中星形胶质细胞的增生程度相似,与感染剂量及潜伏期无关联性. 相似文献
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