电化学治疗肺癌的临床观察

电化学治疗肺癌的临床观察辛育龄薛复舟葛炳生赵风瑞宋玉忱权宽宏石彬张伟中日友好医院胸外科（北京１０００２９）１９８７年～１９８９年我们应用电化学疗法治疗中晚期肺癌３８６例，其中男性２８７例，女性９９例，男女之比为３∶１，最大年龄７８岁，最小年龄２５岁，...     

推拿配合刺络拔罐治疗胫骨疲劳性骨膜炎33例

目的:观察推拿配合刺络拔罐治疗胫骨疲劳性骨膜炎的疗效。方法:运用推拿配合刺络拔罐治疗,用长海痛尺评估法进行疼痛评估。结果:连续治疗2个疗程(20天,每天1次)后,患者疼痛显著减轻。结论:推拿配合刺络拔罐治疗胫骨疲劳性骨膜炎有显著疗效。     

肺透明膜病早产儿尸检肺组织肺表面活性蛋白-C及Ki67的表达

Objective To determine the expression of surfactant protein-c (SP-C) and Ki67 in autopsy lung tissues of premature infants died of hyaline membrane disease (HMD) who were exposed to mechanical ventilation and high oxygen concentrations/pulmonary surfactant (PS). The possible influence of surfactant on the expression of SP-C and Ki67 was also investigated. Methods Thirty preterm infants diagnosed as HMD by clinical data and pathology were selected. Mechanical ventilation and supplemental oxygen (FiO2 0.6-1.0) were given to these infants within 6 hours after birth. According to the duration of ventilation at high oxygen concentrations, all subjects were diveded into four groups: ventilation for 1-3 days, 4-8 days, 9-16 days and >16 days. Five premature infants died within 1 day after delivery for none pulmonary reasons served as controls. The expression of SP-C and Ki67 in lungs were detected by immunobistochemistry. Results The pulmonary pathology in these HMD infants at different phases was consisitent with the main features of different stages during the progress from HMD towards bronchopulmonary dysplasia. The positive staining of SP-C was restricted to type Ⅱ alveolar epithelial cells, and Ki67 positive were preferentially localized in nuclei of alveolar and bronchiolar epithelial cells and fihroblasts. Compared with the control group, the expression of SP-C and Ki67 in HMD infants decreased significantly after 1-3 days of ventialation, but increased after 4 days and reached the peak value after 9-16 days. The expression of SP-C and Ki67 in control group, 1-3 days and 9-16 days of ventialation were 0. 1891±0. 0253, 0. 1576±0. 0327 and 0. 2271±0. 0238 for SP-C and 0. 2297±0. 0380, 0.1929±0. 0403 and 0. 2849±0. 0368 for Ki67, respectively. No significant difference in the expression of SP-C and Ki67 was found between infants treated with PS and those without (P>0.05). Conclusions SP-C and Ki67 may have participated in the pulmonary pathological process in ventilated/oxygen treated preterm infants with HMD, and exogenous surfactant had no effect on the expression of SP-C and Ki67.     

艾滋病感染者抗病毒治疗的服药依从性及其相关因素的研究

目的 了解河南省艾滋病病毒感染者／艾滋病患者(HIV／AIDS）高效联合抗病毒疗法(HAART)的服药依从性及其相关因素。方法 抽取了2个AIDS综合防治示范区、1个AIDS高发县。未服药和服药在2—12个月的HIV感染者作为被调查对象，分别对服药依从性、不良反应及临床表现，治疗前后临床症状改善状况及治疗保障措施等项目，通过访谈问卷调查；同时抽取静脉血，测定评价服药者CD4^ T淋巴细胞，病毒载量，用逆转录聚合酶链反应(RT-PCR)方法扩增HIV-1 POL区基因，进行基因型耐药性分析。结果 治疗组治疗时间在4—8个月的人数最多占78．24％，服药依从性达到90％～100％的占67．51％，停服和漏服药物的主要原因是不良反应占66．95％，最显著的不良反应是服药后引起的恶心、呕吐、皮疹等不适。治疗组坚持服药症状明显改善的占87．57％，停服和漏服药症状未明显改善的占11．01％。服药依从性对病情趋势变化具有显著影响(P＜0．05)。治疗组服药后CD4^ T细胞总数保持稳定或有所增加，但实际速度较缓慢。抗病毒治疗3个月和6个月时，患者的病情好转率分别是55．1％和50．8％，CD4^ T细胞数较未服药治疗的患者显著提高。耐药性毒株的流行率显著增加，由未服药人群的13．9％快速上升到服药3个月的45．4％和服药6个月的62．7％，其中对非核苷类逆转录酶抑制剂(NNRTI)类药物耐药性的增加最为明显，导致中高度以上耐药率的显著增加。结论 采取有效的抗病毒治疗以后，HIV／AIDS患者在接受抗病毒治疗过程中，服药依从性直接关系治疗效果以及对治疗计划的实施。避免耐药毒株的出现，必须提高服药依从性，这对今后评价治疗效果具有重要意义。     

肺癌患者咽部、血液、癌组织EB病毒感染及其关系初探

目的:探讨肺癌患者咽部分泌物、血液及癌组织中EB病毒感染情况与肺癌的关系.方法:应用PCR技术和ELISA法对采自30例进展期肺癌患者的咽部分泌物、血液及新鲜肺癌组织标本进行EB病毒检测.结果:肺癌患者咽部分泌物EB病毒感染率低,差异无显著性(P＞0.05);血液EB病毒VCA-IgG抗体高于非癌胸疾病患者(P＜0.01);癌组织中EB病毒感染率为43.3%;不同病理类型肺癌EB病毒感染率差异无显著性;肺癌患者癌组织EB病毒感染率与血液EB病毒VCA-IgG抗体之间呈中度相关.结论:肺癌患者血液及癌组织中EB病毒感染存在增高现象,EB病毒长期感染与肺癌关系密切.     

乙型肝炎后肝硬化病人凝血功能变化指标检测的临床意义

目的研究乙型肝炎后肝硬化病人凝血功能变化与Child-Pugh肝功能分级的关系。方法测定88例乙型肝炎后肝硬化病人与28例健康者的凝血酶原时间（PT）、活化部分凝血酶时间（APTT）、纤维蛋白原。结果乙型肝炎后肝硬化病人存在不同程度凝血功能障碍，PT、APTT、Fbg水平与对照比较，差异有非常显著性，检测结果显示A、B、C级之间PT、APTT、Fbg相互比较，差异有非常显著性。结论乙型肝炎后肝硬化病血浆PT、APTT、Fbg，可作为判定病变程度的指标，可对预后作出有价值的判断，为治疗提供依据。     

结缔组织病合并自发性脑脊液漏及颅内低压12例

自发性脑脊液漏是自发性颅内低压最常见的原因。自发性脑脊液漏的确切原因目前尚不完全了解,普遍认为可能是硬脊-脑膜原始薄弱加上突然发生暴力二者共同作用所造成。硬脑膜结构薄弱使患者容易形成憩室或膨胀或容易发生硬脑膜撕裂使脑脊液漏入硬膜外间隙。结缔组织病     

先天性胆总管囊肿的诊治

目的探对先天性胆总管囊肿的诊治及疗效.方法22例先天性胆总管囊肿中,14例行胆总管囊肿切除,肝总管空肠Roux-en-Y吻合术;8例行囊肿切除术间置空肠代胆道加矩形瓣术.结果22例患者均治愈出院,无1例死亡.术后随访18例,随访时间1.5-9.5年,平均4.5年,优良率为90%.结论胆总管囊肿切除,肝管空肠Roux-en-Y吻合与间置空肠代胆道加矩形瓣抗返流术是先天性胆总管囊肿切除后胆道重建适宜选用的手术.     

Temporal Expression of Notch in Preterm Rat Lungs Exposed to Hyperoxia

Notch signaling is essential in tissue and organdevelopment. Signals transmitted through theNotch receptor, in combination with other factorsinfluence cell differentiation, proliferation and ap optotic events at all stages of development and re habilitation or remolding of tissues[1]. Previous re searches revealed that Notch receptor/ligand per sistently exists over the whole period of fetal lungdevelopment[2], but it is still unknown how theywork during the chronic lun…     

推拿配合刺络拔罐治疗胫骨疲劳性骨膜炎33例

目的：观察推拿配合刺络拔罐治疗胫骨疲劳性骨膜炎的疗效。方法：运用推拿配合刺络拔罐治疗．用长海痛尺评估法进行疼痛评估。结果：连续治疗2个疗程（20天，每天1次）后，患者疼痛显著减轻。结论：推拿配合刺络拔罐治疗胫骨疲劳性骨膜炎有显著疗效。