疟疾疗法治疗晚期肿瘤的初步报告

［目的］通过初步的临床试验探索疟疗治癌的适应证及疗效,疟疗疗程与疗效的关系,其他抗癌疗法对疟疗的影响和观察疟疗治癌的副作用及并发症。〔方法〕共选择7例晚期肿瘤病人作治疗观察对象,其中乳腺癌1例,小细胞肺癌1例,肺腺癌1例,鼻咽癌1例,胰头癌1例,卡波氏肉瘤1例,直肠癌1例。诱发人工间日疟,疗程为10～17次疟疾阵发。〔结果〕乳腺癌和卡波氏肉瘤共2例部分缓解（PR）,其他5例无效。但值得注意的是2例有效者在疟疗前近期均无化疗史（或不超过一个疗程的化疗史）,而5例无效者均在疟疗前近期有一个疗程以上的化疗史或放射性同位素注射治疗史。未发现疟疗疗程与疗效之间有任何关系。并发症均不严重,1例在疟疗中并发支气管哮喘,另1例并血小板减少,经相应处理均迅速恢复。［结论］初步提示疟疗可能对无化疗史和放射性同位素注射治疗史的某些晚期肿瘤部分缓解,但需进一步研究。根据放疗的热增敏效应提议今后应探索疟疗与放疗相结合的联合疗法。     

Biotechnology—Updates and New Developments

Areas of priority for intensive discovery would be the agbiotechnology and biomedical sectors using gene technology as a platform.The use of genetic manipulation in farming and the use of plants as “pharma“ factories to manufacture therapeutics would be on the rise.The human genome will continue to have a powerful impact on research and development of human diseases and healthcare,Discovery of genetics and pharmacogenomics will have great impact on drug development and will allow the prediction of the patient‘s response to various drugs as well as the onset of individualised or “designer drugs“ .Human stem cells could have their cellular clocks reset by the cloning process,enhancing opportunities to grow young cells,tissues and organs for an aging population. The cellular clock could also be reset by therapeutic cloning .Bioinformatics would be a technology which would be synonymous with biotechnology,The analyses of biotechnology research would be conducted in silico and would involive the exchange of information among sophisticated computer databases.Application of biotechnology would be even more evident in environmental technology,food development and food rpocessing,In electronics,the use of the specificity of proteins in biochips is underway,In tandem with the explosions in research,regulatory issues,legislation and intellectual property rights will evolve to enhance the climate of discovery and innovation .Public education will have to be continually enhanced as awareness could negate any fear resulting from novel and innovative improveents from biotechnology.     

特发性膜性肾病患者血压水平与肾间质病变的关系

目的:探讨特发性膜性肾病(idiopathic membranous nephropathy, IMN)患者血压与肾间质病变的相关关系。方法:本研究为单中心横断面研究，纳入肾活检确诊为IMN的患者347例，按肾间质病变严重程度分为无病变组(46例),轻微组(283例),中-重度组(18例)。比较各组患者一般情况、生化及肾脏病理等指标，采用多重线性及Logistic回归分析收缩压、舒张压、脉压差及平均动脉压与肾间质病变积分及有无肾间质病变的关系。结果:多重线性回归分析结果显示调整混杂因素后，收缩压(β=0.006,95%CI 0.001,0.011,P=0.013)、舒张压(β=0.010,95%CI 0.002,0.019,P=0.015)、平均动脉压(β=0.010,95%CI 0.003,0.017,P<0.001)与肾间质病变积分独立相关。多因素Logistic回归分析结果提示收缩压(OR=1.024,95%CI 1.004,1.045,P=0.016)、舒张压(OR=1.039,95%CI 1.008,1.072,P=0.014)、平均动脉压(OR=1.039,95%CI...     

前列腺素治疗消化性溃疡

许多前刊腺素，尤其是E系列能抑制胃酸分泌．PGE1和PGE2类似物在与壁细胞接触的部位或在腺苷酸环化酶处能有效地抑制胃酸分秘．Jacobson等认为使用不减步胃酸分泌剂盘的前列腺素具有相对预防粘胶损害的作用，     

兔瘟的发生及防治措施

兔病毒性出血症俗称“兔瘟”，是由兔病毒性出性病毒引起的兔的一种 急性、高度接触性传染病，主要特征及呼吸系统出血，肝坏死，实质脏器，肝坏死，实质脏器水肿、瘀血及出血性症状，本病发病率及病死率极高，常呈爆发性流行。是养兔业一大灾害。     

汤钊猷院士荣获"中国工程科技奖"

本刊总编辑，原上海医科大学肝癌研究所所长汤钊猷院士获得了中国工程院设立的"中国工程科技奖"。表彰他自60年代末以来，在肝癌临床诊治和基础性研究方面的显著成就。他最早对小肝癌进行了系统研究，使手术切除后5年生存率达到60％～70％，将病人5年生存率提高到68．4％。这些重大成果使我国肝癌临床诊治水平长期处于国际领先地位，他提出的"亚临床肝癌"概念和理论的建立，被国际权威称为是人类认识和治疗肝癌的重大进展。 本刊编辑部     

腹腔镜模拟训练在腔镜外科中的应用

目的探讨腹腔镜模拟训练机对不同临床经验参与者的培训效果。方法在腹腔镜模拟机上培训9名无任何临床经验的志愿者(对照组)、9名6年级医学实习生(学生组)和9名有2～3年临床经验的住院医生(医生组),包括0°、30°腹腔镜的操作、眼-手协调、钛夹应用、抓-钳夹、剪切、电凝和物体转运,每天训练30min,共5d,比较培训前后各组的得分。结果培训前3组在0°、30°腹腔镜的操作,抓-钳夹,电凝,眼-手协调得分都有统计学差异(P<0.05);培训后各组在0°腹腔镜的操作、抓-钳夹、眼-手协调的得分有统计学差异(P<0.05)。所有参与者培训后在0°、30°腹腔镜操作、电凝得分和眼-手协调得分和时间均较培训前明显提高(P<0.05)。结论腹腔镜模拟训练机培训可以提高不同临床经验参与者的腹腔镜操作技巧,并且可以区分不同临床经验者。     

TREATMENT OF SCHISlOSOMIASIS JAPONICA WITH FOUADIN IN EXPERI:MENTALLY . INFECTED RABBITS

Fouadin, the trade narrie of a new organic antimony compound, was rccently introduced by the German Chemical firm, Bayer and Company, for the treatment of the Egyptian forms of schistosomiasiS. Reports by Khalil and his co-workers (l. v., :3, 4) indicate iti superiori- ty ovcr tartar emctic and other organic antimony ccmpounds. Apart from the small series of succcssfully treated dases reported by Kastien (5) and Low ar.d FrankLin (6), its value in schistosomiasis japonica has not been seriously .stucliecl. The present -.eport embodies results of a study on the therapeutic value of fouadin in rabbits experimentally infected vvith Schisto.soma japonicum.