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Objective: To explore the risk factors and prophylaxis and treatment of cytomegalovirus interstitial pneumonitis (CMV-IP) after allogeneic peripheral blood stem cell transplantation (allo-PBSCT). Methods: 43 patients who received allo-PBSCT were allocated to either a Gancyclovir(GCV)-prophylaxis group (n=19) or a non-GCV prophylaxis group (n=24). A comparison was made of the incidence of CMV-IP in patients given or not given prophylactic gancyclovir. Results: 9 patients in non-GCV prophylaxis group developed late CMV-IP (P〈0.05). Graft-versus-host-disease (GVHD) may be associated with a high risk of CMV-IP. 5 cases of CMV-IP were successfully treated with GCV, but 3 cases died of CMV-IP. The most common adverse event of GCV was neutropenia, but was reversible. Conclusion: CMV infection was a major cause of interstitial pneumonitis after allo-PBSCT, which correlated strongly with the severity of GVHD. Gancyclovir was shown to be effective in both prophylaxis and treatment of CMV-IP. 相似文献
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Objective: To analyze long-term outcome in sixty leukemia patients received allogeneic hematopoietic stem cell transplantation (allo-HSCT) following busulfan and cyclophosphamide (BU-CY2) between 1994 and 2000.Methods: BU-CY2 was used as the conditioning regimen and allo-HSCT was performed for all patients. All the patients were followed-up until August 2001 or death. The leukemia-free survival, relapse and transplant-related mortality were discussed. Results: All 60 patients had sustained engraftment. Acute GVHD occurred in 22 out of 60 patients (36.7%), and the incidence of acute GVHD was 48% in the patients with CML, 30% in AML and 26.7% in ALL. 38 patients are still alive in continuous remission with a median follow-up of 30 months (range 12-84) and 22 patients have died. The main causes of death were acute GVHD in 3 patients, CMV-IP in 7 patients and relapse in 11 patients,the remaining one died of pulmonary infection. Among 11 patients who died of relapse, 8 patients with ALL relapsed in the early stage post transplant (8115, 53.3%), relapse was observed in the remaining 3 patients with AML, and however, no relapse was observed in CML. The probability of disease-free survival at 3 years for CML. AML and ALL patients was 80%, 70% and 26.7%, respectively.Conclusion: This results suggests that BU-CY2 is an effective conditioning regimen in patients with AML and CML, resulting in a low relapse rate and high long-term survival rate, but not as effective in patients with ALL, with a higher incidence of relapse and therefore, not recommended for ALL patients. 相似文献
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异基因外周血干细胞移植治疗骨髓移植失败后地中海贫血一例 总被引:3,自引:0,他引:3
我们在中国大陆首次用HLA不合的同胞外周血干细胞移植 (PBSCT)治疗 1例骨髓移植 (BMT)失败的重型 β地中海贫血 (珠蛋白生成障碍性贫血 ,地贫 )患儿 ,报告如下。患儿 ,女 ,2 .5岁。体重 12kg ,体表面积 0 .5 2m2 ,2 0 0 1年7月入院。患儿出生后 6个月时诊断为 β地贫 (重型 ) ,基因型 4 1 4 2 /41 4 2 (纯合子 )。父亲基因型 4 1 4 2 /N ,母亲 4 1 4 2 /N ,胞兄 4 1 4 2 /N(3人均为轻型杂合子 )。 1999年 12月 ,患儿11个月时 ,于外院行allo BMT。供者为其胞兄 (12岁 )。供、受者HLA A 1个主要位点不合 ,血型均… 相似文献
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例1,女,28岁。因确诊慢性粒细胞白血病8年、急单变3个月拟行异基因造血干细胞移植收住我院血液科。于2003年12月26日行异基因外周血干细胞移植,供者为胞姐,HLA配型是1个主要位点不相合,预处理方案为:马利兰(16 mg/kg)加 相似文献